{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T01:59:27Z","timestamp":1791251967713,"version":"4.1.0"},"reference-count":41,"publisher":"American Academy of Pediatrics (AAP)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,7,1]]},"abstract":"<jats:sec>\n                  <jats:title>OBJECTIVE:<\/jats:title>\n                  <jats:p>The goal of this study was to compare the analgesic effect of sucrose with that of the combination of sucrose and the local anesthetic cream EMLA during venipuncture in preterm neonates.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS:<\/jats:title>\n                  <jats:p>This randomized, double-blind prospective study included infants younger than 37 weeks' gestational age during 1 routine venipuncture for blood sampling. Each child randomly received either sucrose plus application of a placebo cream (S group) or sucrose plus EMLA cream (S+E group) before venipuncture. Venipuncture-induced pain was assessed through videotapes of the procedures by using the Douleur Aigu\u00eb Nouveau-n\u00e9 (DAN) behavioral scale. Pain was assessed at 2 phases: during venipuncture (from needle introduction to its removal) and during the recovery period (30 seconds after needle removal). Pain scores over time and between treatments were compared by using repeated-measures analysis of variance.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS:<\/jats:title>\n                  <jats:p>The study included 76 children (37 in the S group, 39 in the S+E group). Mean (SD) DAN pain scores for the S group and the S+E group were 7.7 (2.1) and 6.4 (2.5), respectively, during venipuncture and 7.1 (2.8) and 5.7 (3.3) during the postinjection period. A significant time and treatment effect in favor of the S+E group was observed.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSION:<\/jats:title>\n                  <jats:p>The combination of sucrose and EMLA cream revealed a higher analgesic effect than sucrose alone during venipuncture in these preterm infants.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1542\/peds.2010-1287","type":"journal-article","created":{"date-parts":[[2011,6,14]],"date-time":"2011-06-14T00:14:18Z","timestamp":1308010458000},"page":"e63-e70","source":"Crossref","is-referenced-by-count":45,"title":["Analgesic Effects of EMLA Cream and Oral Sucrose During Venipuncture in Preterm Infants"],"prefix":"10.1542","volume":"128","author":[{"given":"Val\u00e9rie","family":"Biran","sequence":"first","affiliation":[{"name":"Service de N\u00e9onatologie, H\u00f4pital Armand Trousseau, Assistance Publique-H\u00f4pitaux de Paris, Paris, France;"},{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, Paris, France;"},{"name":"PremUP, Paris, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth","family":"Gourrier","sequence":"additional","affiliation":[{"name":"Service de N\u00e9onatologie, Centre Hospitalier de Meaux, Meaux, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Cimerman","sequence":"additional","affiliation":[{"name":"Centre National de Ressources de Lutte Contre la Douleur, H\u00f4pital Armand Trousseau, Assistance Publique-H\u00f4pitaux de Paris, Paris, France; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Walter-Nicolet","sequence":"additional","affiliation":[{"name":"Service de N\u00e9onatologie, H\u00f4pital Armand Trousseau, Assistance Publique-H\u00f4pitaux de Paris, Paris, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Delphine","family":"Mitanchez","sequence":"additional","affiliation":[{"name":"Service de N\u00e9onatologie, H\u00f4pital Armand Trousseau, Assistance Publique-H\u00f4pitaux de Paris, Paris, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo","family":"Carbajal","sequence":"additional","affiliation":[{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, Paris, France;"},{"name":"Service des Urgences P\u00e9diatriques, H\u00f4pital Armand Trousseau, Assistance Publique-H\u00f4pitaux de Paris, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"417","published-online":{"date-parts":[[2011,7,1]]},"reference":[{"issue":"21","key":"2021120900025202100_B1","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1056\/NEJM198711193172105","article-title":"Pain and its effects in the human neonate and fetus","volume":"317","author":"Anand","year":"1987","journal-title":"N Engl J Med"},{"issue":"4","key":"2021120900025202100_B2","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1097\/00004703-199908000-00008","article-title":"Long-term effects of pain in infants","volume":"20","author":"Porter","year":"1999","journal-title":"J Dev Behav Pediatr"},{"issue":"9052","key":"2021120900025202100_B3","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/S0140-6736(96)10316-0","article-title":"Effect of neonatal circumcision on pain response during subsequent routine vaccination","volume":"349","author":"Taddio","year":"1997","journal-title":"Lancet"},{"issue":"4","key":"2021120900025202100_B4","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.siny.2006.02.007","article-title":"Long-term consequences of pain in human neonates","volume":"11","author":"Grunau","year":"2006","journal-title":"Semin Fetal Neonatal Med"},{"issue":"2","key":"2021120900025202100_B5","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1001\/archpedi.155.2.173","article-title":"Consensus statement for the prevention and management of pain in the newborn","volume":"155","author":"Anand","year":"2001","journal-title":"Arch Pediatr Adolesc Med"},{"issue":"2","key":"2021120900025202100_B6","first-page":"454","article-title":"Prevention and management of pain and stress in the neonate. 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