{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T19:32:30Z","timestamp":1757705550839,"version":"3.40.5"},"reference-count":15,"publisher":"American Academy of Pediatrics (AAP)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,12,1]]},"abstract":"<jats:p>Fibroblast growth factor 23 (FGF-23) is a recently identified hormone that is of prime importance for phosphate homeostasis in humans. FGF-23 is secreted by osteocytes in response to phosphate-loading. It stimulates renal phosphate excretion and suppresses the formation of 1.25-dihydroxy-vitamin D by inhibiting renal 1\u03b1-hydroxylase activity. Knowledge about FGF-23 in early infancy is limited. We report here the case of a newborn with transient secondary hypoparathyroidism caused by maternal primary hyperparathyroidism during pregnancy. FGF-23 levels at birth were extremely high in the child (15.850 kilo-Relative Units per liter, kRU\/L) (ie, \u223c45 times higher than in the mother) and \u223c7 times higher than in healthy newborns. The child's FGF-23 levels declined gradually and reached the normal adult range after \u223c7 months. We discuss the potential physiologic significance of FGF-23 in newborns.<\/jats:p>","DOI":"10.1542\/peds.2010-1365","type":"journal-article","created":{"date-parts":[[2010,11,2]],"date-time":"2010-11-02T03:53:25Z","timestamp":1288670005000},"page":"e1613-e1616","source":"Crossref","is-referenced-by-count":3,"title":["Elevated Fibroblast Growth Factor 23 Levels in a Newborn With Secondary Hypoparathyroidism"],"prefix":"10.1542","volume":"126","author":[{"given":"Anneke","family":"Bech","sequence":"first","affiliation":[{"name":"Departments of Internal Medicine,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karin","family":"Nabbe","sequence":"additional","affiliation":[{"name":"Clinical Chemistry, and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wim","family":"Brussel","sequence":"additional","affiliation":[{"name":"Pediatrics, Rijnstate Hospital, Arnhem, 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