{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T07:05:58Z","timestamp":1769238358096,"version":"3.49.0"},"reference-count":9,"publisher":"American Academy of Pediatrics (AAP)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,5,1]]},"abstract":"<jats:p>Mutations in the gene for adenosine triphosphate\u2013binding cassette transporter A3 (ABCA3) have been reported in infants and children with fatal surfactant deficiency and interstitial lung disease. Previously reported radiographic lung findings include ground-glass opacification, streaky infiltrates, and interstitial septal thickening. We report here the unusual case of a newborn who rapidly developed large rounded masses in the lung soon after birth that then resolved spontaneously by 3 months of age. She was found to be a compound heterozygote for both a known and a novel mutation in the ABCA3 gene. This report underscores the diverse clinical presentation of this condition.<\/jats:p>","DOI":"10.1542\/peds.2010-1477","type":"journal-article","created":{"date-parts":[[2011,4,5]],"date-time":"2011-04-05T02:50:04Z","timestamp":1301971804000},"page":"e1347-e1351","source":"Crossref","is-referenced-by-count":5,"title":["Pulmonary Nodules in a Newborn With ATP-Binding Cassette Transporter A3<i>(ABCA3)<\/i>Mutations"],"prefix":"10.1542","volume":"127","author":[{"given":"Derek A.","family":"Uchida","sequence":"first","affiliation":[{"name":"Divisions of Pediatric Pulmonology and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan E.","family":"Wert","sequence":"additional","affiliation":[{"name":"Divisions of Neonatology and Pulmonary Biology, Department of Pediatrics, Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lawrence M.","family":"Nogee","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Department of Pediatrics, Johns Hopkins University, Baltimore, Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Travis R.","family":"Carroll","sequence":"additional","affiliation":[{"name":"Neonatology, Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, Utah;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara A.","family":"Chatfield","sequence":"additional","affiliation":[{"name":"Divisions of Pediatric Pulmonology and"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"417","published-online":{"date-parts":[[2011,5,1]]},"reference":[{"issue":"13","key":"2021121006580095300_B1","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1056\/NEJMoa032178","article-title":"ABCA3 gene mutations in newborns with fatal surfactant deficiency","volume":"350","author":"Shulenin","year":"2004","journal-title":"N Engl J Med"},{"issue":"8","key":"2021121006580095300_B2","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1164\/rccm.200503-504OC","article-title":"ABCA3 mutations associated with pediatric interstitial lung disease","volume":"172","author":"Bullard","year":"2005","journal-title":"Am J Respir Crit Care Med"},{"issue":"4","key":"2021121006580095300_B3","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1136\/thx.2007.083766","article-title":"Clinical, radiological and pathological features of ABCA3 mutations in children","volume":"63","author":"Doan","year":"2008","journal-title":"Thorax"},{"issue":"6","key":"2021121006580095300_B4","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1203\/01.pdr.0000219311.14291.df","article-title":"Surfactant composition and function in patients with ABCA3 mutations","volume":"59","author":"Garmany","year":"2006","journal-title":"Pediatr Res"},{"issue":"25","key":"2021121006580095300_B5","doi-asserted-by":"crossref","first-page":"22147","DOI":"10.1074\/jbc.M201812200","article-title":"Identification of LBM180, a lamellar body limiting protein of alveolar type II cells, as the ABC transporter protein ABCA3","volume":"277","author":"Mulugeta","year":"2002","journal-title":"J Biol Chem"},{"issue":"1","key":"2021121006580095300_B6","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1378\/chest.07-2652","article-title":"Usual interstitial pneumonia in an adolescent with ABCA3 mutations","volume":"134","author":"Young","year":"2008","journal-title":"Chest"},{"issue":"3","key":"2021121006580095300_B7","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/S0033-8389(22)02611-2","article-title":"Nodules, masses, and pseudomasses in the pediatric lung","volume":"31","author":"Eggli","year":"1993","journal-title":"Radiol Clin North Am"},{"issue":"6","key":"2021121006580095300_B8","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1053\/jpsu.2002.32911","article-title":"Spontaneous postnatal resolution of a cystic lung mass: a case report","volume":"37","author":"Barnes","year":"2002","journal-title":"J Pediatr Surg"},{"issue":"1","key":"2021121006580095300_B9","doi-asserted-by":"crossref","first-page":"F73","DOI":"10.1136\/adc.2007.130542","article-title":"Management of congenital cystic adenomatous malformations of the lung","volume":"94","author":"Lakhoo","year":"2009","journal-title":"Arch Dis Child Fetal Neonatal Ed"}],"container-title":["Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/publications.aap.org\/pediatrics\/article-pdf\/127\/5\/e1347\/909268\/zpe005110e1347.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/publications.aap.org\/pediatrics\/article-pdf\/127\/5\/e1347\/909268\/zpe005110e1347.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,5]],"date-time":"2024-04-05T18:56:45Z","timestamp":1712343405000},"score":1,"resource":{"primary":{"URL":"https:\/\/publications.aap.org\/pediatrics\/article\/127\/5\/e1347\/64945\/Pulmonary-Nodules-in-a-Newborn-With-ATP-Binding"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,5,1]]},"references-count":9,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2011,5,1]]},"published-print":{"date-parts":[[2011,5,1]]}},"URL":"https:\/\/doi.org\/10.1542\/peds.2010-1477","relation":{},"ISSN":["0031-4005","1098-4275"],"issn-type":[{"value":"0031-4005","type":"print"},{"value":"1098-4275","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,5,1]]}}}