{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T14:13:42Z","timestamp":1792073622937,"version":"4.4.0"},"reference-count":47,"publisher":"American Academy of Pediatrics (AAP)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,3,1]]},"abstract":"\n OBJECTIVE:<\/jats:title>\n To develop an efficient clinical prediction model that includes postnatal weight gain to identify infants at risk of developing severe retinopathy of prematurity (ROP). Under current birth weight (BW) and gestational age (GA) screening criteria, &lt;5% of infants examined in countries with advanced neonatal care require treatment.<\/jats:p>\n <\/jats:sec>\n \n PATIENTS AND METHODS:<\/jats:title>\n This study was a secondary analysis of prospective data from the Premature Infants in Need of Transfusion Study, which enrolled 451 infants with a BW &lt; 1000 g at 10 centers. There were 367 infants who remained after excluding deaths (82) and missing weights (2). Multivariate logistic regression was used to predict severe ROP (stage 3 or treatment).<\/jats:p>\n <\/jats:sec>\n \n RESULTS:<\/jats:title>\n Median BW was 800 g (445\u2013995). There were 67 (18.3%) infants who had severe ROP. The model included GA, BW, and daily weight gain rate. Run weekly, an alarm that indicated need for eye examinations occurred when the predicted probability of severe ROP was &gt;0.085. This identified 66 of 67 severe ROP infants (sensitivity of 99% [95% confidence interval: 94%\u2013100%]), and all 33 infants requiring treatment. Median alarm-to-outcome time was 10.8 weeks (range: 1.9\u201317.6). There were 110 (30%) infants who had no alarm. Nomograms were developed to determine risk of severe ROP by BW, GA, and postnatal weight gain.<\/jats:p>\n <\/jats:sec>\n \n CONCLUSION:<\/jats:title>\n In a high-risk cohort, a BW-GA-weight-gain model could have reduced the need for examinations by 30%, while still identifying all infants requiring laser surgery. Additional studies are required to determine whether including larger-BW, lower-risk infants would reduce examinations further and to validate the prediction model and nomograms before clinical use.<\/jats:p>\n <\/jats:sec>","DOI":"10.1542\/peds.2010-2240","type":"journal-article","created":{"date-parts":[[2011,2,15]],"date-time":"2011-02-15T09:55:10Z","timestamp":1297763710000},"page":"e607-e614","source":"Crossref","is-referenced-by-count":104,"title":["A Clinical Prediction Model to Stratify Retinopathy of Prematurity Risk Using Postnatal Weight Gain"],"prefix":"10.1542","volume":"127","author":[{"given":"Gil","family":"Binenbaum","sequence":"first","affiliation":[{"name":"Divisions of Ophthalmology and"},{"name":"Department of Ophthalmology, Scheie Eye Institute, University of Pennsylvania, Philadelphia, Pennsylvania;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gui-shuang","family":"Ying","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Scheie Eye Institute, University of Pennsylvania, Philadelphia, Pennsylvania;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graham E.","family":"Quinn","sequence":"additional","affiliation":[{"name":"Divisions of Ophthalmology and"},{"name":"Department of Ophthalmology, Scheie Eye Institute, University of Pennsylvania, Philadelphia, Pennsylvania;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"Dreiseitl","sequence":"additional","affiliation":[{"name":"Department of Software Engineering, Upper Austria University of Applied Sciences at Hagenberg, Austria; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Karp","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Scheie Eye Institute, University of Pennsylvania, Philadelphia, Pennsylvania;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robin S.","family":"Roberts","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haresh","family":"Kirpalani","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada"},{"name":"Neonatology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the Premature Infants in Need of Transfusion Study Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"417","published-online":{"date-parts":[[2011,3,1]]},"reference":[{"issue":"2","key":"2021121006592676600_B1","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.earlhumdev.2007.11.009","article-title":"Retinopathy of prematurity: a global perspective of the epidemics, population of babies at risk and implications for control","volume":"84","author":"Gilbert","year":"2008","journal-title":"Early Hum Dev"},{"issue":"5","key":"2021121006592676600_B2","doi-asserted-by":"crossref","DOI":"10.1542\/peds.2004-1180","article-title":"Characteristics of infants with severe retinopathy of prematurity in countries with low, moderate, and high levels of development: implications for screening programs","volume":"115","author":"Gilbert","year":"2005","journal-title":"Pediatrics"},{"issue":"9","key":"2021121006592676600_B3","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1136\/bjo.85.9.1025","article-title":"Blindness in children: control priorities and research opportunities","volume":"85","author":"Gilbert","year":"2001","journal-title":"Br J Ophthalmol"},{"issue":"4","key":"2021121006592676600_B4","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1001\/archopht.1988.01060130517027","article-title":"Multicenter trial of cryotherapy for retinopathy of prematurity. 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