{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T22:09:40Z","timestamp":1792534180193,"version":"4.5.0"},"reference-count":41,"publisher":"American Academy of Pediatrics (AAP)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,4,1]]},"abstract":"<jats:sec><jats:title>OBJECTIVE:<\/jats:title><jats:p>To determine whether mild and severe growth restriction at birth among preterm infants is associated with neonatal mortality and cerebral palsy and cognitive performance at 5 years of age and school performance at 8 years of age.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS:<\/jats:title><jats:p>All 2846 live births between 24 and 32 weeks' gestation from 9 regions in France in 1997 were included in a prospective observational study (the EPIPAGE [\u00c9tude Epid\u00e9miologique sur les Petits Ages Gestationnels] study) and followed until 8 years of age. Infants were classified as \u201csmall-for-gestational-age\u201d (SGA) if their birth weight for gestational age was at the &amp;lt;10th centile, \u201cmildly-small-for-gestational-age\u201d (M-SGA) if birth weight was at the \u226510th centile and &amp;lt;20th centile, and \u201cappropriate-for-gestational-age\u201d (AGA) if birth weight was at the \u226520th centile.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS:<\/jats:title><jats:p>Among the children born between 24 and 28 weeks' gestation, the mortality rate increased from 30% in the AGA group to 42% in the M-SGA group and to 62% in the SGA group (P &amp;lt; .01). Birth weight was not significantly associated with any cognitive, behavioral, or motor outcomes at the age of 5 or any school performance outcomes at 8 years. For the children born between 29 and 32 weeks' gestation, SGA children had a higher risk for mortality (adjusted odds ratio [aOR]: 2.79 [95% confidence interval (CI): 1.50\u20135.20]), minor cognitive difficulties (aOR: 1.73 [95% CI: 1.12\u20132.69]), inattention-hyperactivity symptoms (aOR: 1.78 [95% CI: 1.10\u20132.89]), and school difficulties (aOR: 1.74 [1.07\u20132.82]) compared with AGA children. Being born M-SGA was associated with an increased risk for minor cognitive difficulties (aOR: 1.87 [95% CI: 1.24\u20132.82]) and behavioral difficulties (aOR: 1.66 [95% CI: 1.04\u20132.62]).<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS:<\/jats:title><jats:p>In preterm children, growth restriction was associated with mortality, cognitive and behavioral outcomes, as well as school difficulties.<\/jats:p><\/jats:sec>","DOI":"10.1542\/peds.2010-2442","type":"journal-article","created":{"date-parts":[[2011,3,8]],"date-time":"2011-03-08T06:09:09Z","timestamp":1299564549000},"page":"e883-e891","source":"Crossref","is-referenced-by-count":175,"title":["Neurologic Outcomes at School Age in Very Preterm Infants Born With Severe or Mild Growth Restriction"],"prefix":"10.1542","volume":"127","author":[{"given":"Isabelle","family":"Guellec","sequence":"first","affiliation":[{"name":"INSERM, UMR 953, Epidemiological Research in Perinatal Health and Women's and Children Health, B\u00e2timent de recherche, H\u00f4pital Tenon, Paris, France;"},{"name":"Assistance Publique-H\u00f4pitaux de Paris [APHP], R\u00e9animation N\u00e9onatale et P\u00e9diatrique, H\u00f4pital Trousseau, Paris, France;"},{"name":"UPMC, Universit\u00e9 Paris, Paris, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre","family":"Lapillonne","sequence":"additional","affiliation":[{"name":"Assistance Publique-H\u00f4pitaux de Paris, Service de Neonatologie, H\u00f4pital Necker Enfants Malades, Paris, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvain","family":"Renolleau","sequence":"additional","affiliation":[{"name":"Assistance Publique-H\u00f4pitaux de Paris [APHP], R\u00e9animation N\u00e9onatale et P\u00e9diatrique, H\u00f4pital Trousseau, Paris, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Laure","family":"Charlaluk","sequence":"additional","affiliation":[{"name":"INSERM, UMR 953, Epidemiological Research in Perinatal Health and Women's and Children Health, B\u00e2timent de recherche, H\u00f4pital Tenon, Paris, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Christophe","family":"Roze","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Children Hospital, Nantes, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phane","family":"Marret","sequence":"additional","affiliation":[{"name":"Neonatal Medicine, University Hospital, Rouen, France;"},{"name":"Institute of Biomedical Research, INSERM Group, IFR 23, Rouen, France; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"Vieux","sequence":"additional","affiliation":[{"name":"A. 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