{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T15:27:26Z","timestamp":1791214046356,"version":"4.1.0"},"reference-count":50,"publisher":"American Academy of Pediatrics (AAP)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,5,1]]},"abstract":"<jats:sec>\n                  <jats:title>OBJECTIVE:<\/jats:title>\n                  <jats:p>Familial aggregation of autoimmune diseases likely reflects shared pathogenic factors between different diseases. Familial aggregation of autoimmunity has not been examined in juvenile dermatomyositis. Interferon-\u03b1 is thought to be a pathogenic factor in both systemic lupus erythematosus and juvenile dermatomyositis, and we have previously demonstrated familial aggregation of serum interferon-\u03b1.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS:<\/jats:title>\n                  <jats:p>Family histories were obtained from 304 families of children with juvenile dermatomyositis via 3-generation structured interviews performed by the same person. Rates of autoimmune disease in families of children with juvenile dermatomyositis were compared with published population rates. Serum interferon-\u03b1, tumor necrosis factor-\u03b1, and neopterin were measured using standard techniques.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS:<\/jats:title>\n                  <jats:p>A total of 51% of families of children with juvenile dermatomyositis reported at least 1 additional member affected by an autoimmune disease. In particular, both type 1 diabetes and systemic lupus erythematosus were significantly more common than would be expected (odds ratio &amp;gt;5, P \u2264 1 \u00d7 10\u22127 for both). Pedigree analysis showed particularly strong familial clustering of systemic lupus erythematosus with little decrease in incidence across generations, suggesting the possibility of rare causal genes with large effect. Untreated subjects with juvenile dermatomyositis with a family history of systemic lupus erythematosus had higher serum interferon-\u03b1 than those who did not (P = .047).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS:<\/jats:title>\n                  <jats:p>We find strong familial aggregation of specific autoimmune diseases in families of children with juvenile dermatomyositis, suggesting that these conditions share pathogenic factors. Higher serum interferon-\u03b1 in juvenile dermatomyositis patients with a family history of systemic lupus erythematosus suggesting that interferon-\u03b1 is one such shared factor.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1542\/peds.2010-3022","type":"journal-article","created":{"date-parts":[[2011,4,19]],"date-time":"2011-04-19T03:31:46Z","timestamp":1303183906000},"page":"e1239-e1246","source":"Crossref","is-referenced-by-count":66,"title":["Familial Aggregation of Autoimmune Disease in Juvenile Dermatomyositis"],"prefix":"10.1542","volume":"127","author":[{"given":"Timothy B.","family":"Niewold","sequence":"first","affiliation":[{"name":"Section of Rheumatology, Gwen Knapp Center for Lupus and Immunology Research, Pritzker School of Medicine, University of Chicago, Chicago, Illinois;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie C.","family":"Wu","sequence":"additional","affiliation":[{"name":"University of Illinois College of Medicine, University of Illinois at Chicago, Chicago, Illinois;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Molly","family":"Smith","sequence":"additional","affiliation":[{"name":"Cure JM Program of Excellence, Children's Memorial Research Center, Chicago, Illinois;"},{"name":"Wellesley College, Wellesley, Massachusetts; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabrielle A.","family":"Morgan","sequence":"additional","affiliation":[{"name":"Cure JM Program of Excellence, Children's Memorial Research Center, Chicago, Illinois;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren M.","family":"Pachman","sequence":"additional","affiliation":[{"name":"Cure JM Program of Excellence, Children's Memorial Research Center, Chicago, Illinois;"},{"name":"Division of Rheumatology, Department of Pediatrics, Feinberg School of Medicine, Children's Memorial Hospital, Northwestern University, Chicago, 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