{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T18:04:43Z","timestamp":1790013883385,"version":"4.0.1"},"reference-count":8,"publisher":"American Academy of Pediatrics (AAP)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,8,1]]},"abstract":"<jats:p>Therapeutic moderate hypothermia in newborns with hypoxic-ischemic encephalopathy is rapidly becoming standard clinical practice. We report here 12 cases of subcutaneous fat necrosis among 1239 cases registered with a national registry of newborns treated with moderate whole-body hypothermia. All the infants suffered from perinatal asphyxia and hypoxic-ischemic encephalopathy. Moderate-to-severe hypercalcemia was identified in 8 of 10 infants with blood calcium measurements. In all cases the skin lesions appeared after completion of the cooling treatment. Our data suggest that prolonged moderate hypothermia is an actual risk factor for subcutaneous fat necrosis. Because the lesions often develop several days after birth, physicians need to be aware of this condition as a possible complication in infants treated with moderate hypothermia after asphyxia. Blood calcium levels need to be monitored in affected infants.<\/jats:p>","DOI":"10.1542\/peds.2010-3508","type":"journal-article","created":{"date-parts":[[2011,7,5]],"date-time":"2011-07-05T00:35:48Z","timestamp":1309826148000},"page":"e450-e452","source":"Crossref","is-referenced-by-count":79,"title":["Subcutaneous Fat Necrosis After Moderate Therapeutic Hypothermia in Neonates"],"prefix":"10.1542","volume":"128","author":[{"given":"Brenda","family":"Strohm","sequence":"first","affiliation":[{"name":"National Perinatal Epidemiology Unit, Oxford, United Kingdom; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Hobson","sequence":"additional","affiliation":[{"name":"National Perinatal Epidemiology Unit, Oxford, United Kingdom; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Brocklehurst","sequence":"additional","affiliation":[{"name":"National Perinatal Epidemiology Unit, Oxford, United Kingdom; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. David","family":"Edwards","sequence":"additional","affiliation":[{"name":"Institute of Clinical Sciences, Medical Research Council, Imperial College, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denis","family":"Azzopardi","sequence":"additional","affiliation":[{"name":"Institute of Clinical Sciences, Medical Research Council, Imperial College, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"417","published-online":{"date-parts":[[2011,8,1]]},"reference":[{"key":"2021120823424355700_B1","doi-asserted-by":"crossref","first-page":"c363","DOI":"10.1136\/bmj.c363","article-title":"Neurological outcomes at 18 months of age after moderate hypothermia for perinatal hypoxic ischaemic encephalopathy: synthesis and meta-analysis of trial data","volume":"340","author":"Edwards","year":"2010","journal-title":"BMJ"},{"issue":"4","key":"2021120823424355700_B2","doi-asserted-by":"crossref","first-page":"F260","DOI":"10.1136\/adc.2008.146977","article-title":"Treatment of asphyxiated newborns with moderate hypothermia in routine clinical practice: how cooling is managed in the UK outside a clinical trial","volume":"94","author":"Azzopardi","year":"2009","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"issue":"4","key":"2021120823424355700_B3","doi-asserted-by":"crossref","first-page":"F304","DOI":"10.1136\/adc.2006.114090","article-title":"Neonatal subcutaneous fat necrosis with characteristic rash and hypercalcemia","volume":"92","author":"Aucharaz","year":"2007","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"2021120823424355700_B4","doi-asserted-by":"crossref","first-page":"14.37","DOI":"10.1002\/9780470750520.ch14","article-title":"The neonate","volume-title":"Rook's Textbook of Dermatology","author":"Atherton","year":"2004"},{"issue":"15","key":"2021120823424355700_B5","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1056\/NEJMcps050929","article-title":"Whole-body hypothermia for neonates with hypoxic-ischemic encephalopathy","volume":"353","author":"Shankaran","year":"2005","journal-title":"N Engl J Med"},{"issue":"8","key":"2021120823424355700_B6","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1001\/archdermatol.2010.176","article-title":"Subcutaneous fat necrosis as a complication of whole-body cooling for birth asphyxia","volume":"146","author":"Oza","year":"2010","journal-title":"Arch Dermatol"},{"issue":"7","key":"2021120823424355700_B7","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1038\/jp.2008.33","article-title":"Sclerema neonatorum: a review of nomenclature, clinical presentation, histological features, differential diagnoses and management","volume":"28","author":"Zeb","year":"2008","journal-title":"J Perinatol"},{"issue":"5","key":"2021120823424355700_B8","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1016\/S0022-3476(88)80706-6","article-title":"Hypercalcemia with increased and unregulated 1,25-dihydroxyvitamin D production in a neonate with subcutaneous fat necrosis","volume":"112","author":"Finne","year":"1988","journal-title":"J Pediatr"}],"container-title":["Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/publications.aap.org\/pediatrics\/article-pdf\/128\/2\/e450\/843528\/zpe0081100e450.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/publications.aap.org\/pediatrics\/article-pdf\/128\/2\/e450\/843528\/zpe0081100e450.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,9]],"date-time":"2021-12-09T04:00:17Z","timestamp":1639022417000},"score":1,"resource":{"primary":{"URL":"https:\/\/publications.aap.org\/pediatrics\/article\/128\/2\/e450\/30649\/Subcutaneous-Fat-Necrosis-After-Moderate"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,8,1]]},"references-count":8,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2011,8,1]]},"published-print":{"date-parts":[[2011,8,1]]}},"URL":"https:\/\/doi.org\/10.1542\/peds.2010-3508","relation":{},"ISSN":["0031-4005","1098-4275"],"issn-type":[{"value":"0031-4005","type":"print"},{"value":"1098-4275","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,8,1]]}}}