{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T04:55:37Z","timestamp":1764996937312,"version":"3.40.5"},"reference-count":13,"publisher":"American Academy of Pediatrics (AAP)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,5,1]]},"abstract":"<jats:p>Persistently patent ductus arteriosus (PDA), affecting approximately one-third of all very low birth weight infants, can lead to significant morbidity and mortality. Recently, ibuprofen has been recommended over indomethacin to close PDAs because of a reduction in risk of necrotizing enterocolitis. Pulmonary hypertension is a rare but potentially fatal complication of ibuprofen administration in preterm infants. We report 2 infants who developed this complication after receiving therapeutic l-lysine ibuprofen preparation for the PDA closure. The first infant, 1 of twins weighing 640 g, was born at 24 weeks\u2019 gestation. The second infant, born at 26 weeks\u2019 gestation, was small for gestational age, weighing 439 g. In both cases, ibuprofen was initiated after echocardiographic confirmation of a moderate-sized to large PDA and an otherwise normal intracardiac anatomy. Both infants had echocardiographic evidence of increased pulmonary vascular resistance but shunting across the PDA was left to right. The infants deteriorated within 48 to 72 hours, and repeat echocardiograms revealed evidence of severe pulmonary hypertension. Both infants died of refractory hypotension and hypoxemia. When considering the use of ibuprofen therapy for PDA closure, clinicians should keep in mind the potential serious complication of pulmonary hypertension, even if a shunt across the PDA is left to right.<\/jats:p>","DOI":"10.1542\/peds.2011-0117","type":"journal-article","created":{"date-parts":[[2012,4,10]],"date-time":"2012-04-10T00:14:41Z","timestamp":1334016881000},"page":"e1360-e1363","source":"Crossref","is-referenced-by-count":21,"title":["Severe Pulmonary Hypertension With Therapeutic <scp>l<\/scp>-Lysine Ibuprofen in 2 Preterm Neonates"],"prefix":"10.1542","volume":"129","author":[{"given":"Barbara","family":"Amendolia","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Cooper University Hospital, Camden, New Jersey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Madeline","family":"Lynn","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Cooper University Hospital, Camden, New Jersey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vishwanath","family":"Bhat","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Cooper University Hospital, Camden, New Jersey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven B.","family":"Ritz","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Cooper University Hospital, Camden, New Jersey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zubair H.","family":"Aghai","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Cooper University Hospital, Camden, New Jersey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"417","published-online":{"date-parts":[[2012,5,1]]},"reference":[{"issue":"5","key":"2022051617020602900_B1","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1542\/peds.2009-3506","article-title":"Patent ductus arteriosus of the preterm infant.","volume":"125","author":"Hamrick","year":"2010","journal-title":"Pediatrics"},{"key":"2022051617020602900_B2","first-page":"CD003481","article-title":"Ibuprofen for the treatment of patent ductus arteriosus in preterm and\/or low birth weight infants.","volume":"14","author":"Ohlsson","year":"2010","journal-title":"Cochrane Database Syst Rev"},{"issue":"5","key":"2022051617020602900_B3","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1055\/s-0029-1243371","article-title":"Safety and effectiveness of indomethacin versus ibuprofen for treatment of patent ductus arteriosus.","volume":"27","author":"Katakam","year":"2010","journal-title":"Am J Perinatol"},{"issue":"9449","key":"2022051617020602900_B4","doi-asserted-by":"crossref","first-page":"1939","DOI":"10.1016\/S0140-6736(04)17476-X","article-title":"Prophylactic ibuprofen versus placebo in very premature infants: a randomised, double-blind, placebo-controlled 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