{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T11:39:59Z","timestamp":1769168399439,"version":"3.49.0"},"reference-count":43,"publisher":"American Academy of Pediatrics (AAP)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,10,1]]},"abstract":"<jats:sec><jats:title>BACKGROUND:<\/jats:title><jats:p>Neonatal blue light phototherapy (NBLP) has been widely and successfully used for the treatment of neonatal jaundice to reduce the plasma concentration of bilirubin and, hence, to prevent kernicterus. Only a few and controversial data are available in the literature as to how NBLP influences melanocytic nevus development.<\/jats:p><\/jats:sec><jats:sec><jats:title>OBJECTIVE:<\/jats:title><jats:p>Our goal was to conduct a twin study with the aim of better understanding the role of NBLP in melanocytic nevus development. We also investigated the roles of other environmental and constitutional factors in nevus formation.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS:<\/jats:title><jats:p>Fifty-nine monozygotic and dizygotic twins were included in this cross-sectional study. One of the twin members received NBLP, and the other did not. A whole-body skin examination was performed to determine the density of melanocytic skin lesions. The prevalence of benign pigmented uveal lesions was evaluated during a detailed ophthalmologic examination. A standardized questionnaire was used to assess data relating to constitutional, sun-exposure, and other variables. To search for possible gene-environmental interactions involved in the appearance of pigmented lesions, the melanocortin 1 receptor variants and the I439V polymorphism of histidine ammonia-lyase genes were also determined in the enrolled twins.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS:<\/jats:title><jats:p>NBLP was associated with a significantly higher prevalence of both cutaneous and uveal melanocytic lesions. No association was found between the examined gene polymorphisms and the number of pigmented alterations in the examined study group.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS:<\/jats:title><jats:p>Our data suggest that NBLP could well be a risk factor for melanocytic nevus development. Phototherapy with blue-light lamps is a standard and essential therapeutic modality in neonatal care; therefore, additional in vivo and in vitro studies are necessary to establish its potential long-term adverse effects.<\/jats:p><\/jats:sec>","DOI":"10.1542\/peds.2011-0292","type":"journal-article","created":{"date-parts":[[2011,9,20]],"date-time":"2011-09-20T05:17:35Z","timestamp":1316495855000},"page":"e856-e864","source":"Crossref","is-referenced-by-count":36,"title":["Neonatal Blue Light Phototherapy and Melanocytic Nevi: A Twin Study"],"prefix":"10.1542","volume":"128","author":[{"given":"Zsanett","family":"Csoma","sequence":"first","affiliation":[{"name":"Department of Dermatology and Allergology,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edit","family":"T\u00f3th-Moln\u00e1r","sequence":"additional","affiliation":[{"name":"Novotalex Ltd, Szeged, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kl\u00e1ra","family":"Balogh","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergology,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hilda","family":"Poly\u00e1nka","sequence":"additional","affiliation":[{"name":"Dermatological Research Group of the Hungarian Academy of Sciences, and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hajnalka","family":"Orvos","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University of Szeged, Szeged, Hungary; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henriette","family":"\u00d3csai","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergology,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lajos","family":"Kem\u00e9ny","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergology,"},{"name":"Dermatological Research Group of the Hungarian Academy of Sciences, and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00e1rta","family":"Sz\u00e9ll","sequence":"additional","affiliation":[{"name":"Dermatological Research Group of the Hungarian Academy of Sciences, and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Judit","family":"Ol\u00e1h","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergology,"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"417","published-online":{"date-parts":[[2011,10,1]]},"reference":[{"issue":"12","key":"2021120823464668800_B1","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.1111\/j.1468-3083.2008.02887.x","article-title":"The prevalence of melanocytic naevi among schoolchildren in South Hungary","volume":"22","author":"Csoma","year":"2008","journal-title":"J Eur Acad Dermatol Venereol"},{"issue":"3","key":"2021120823464668800_B2","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1046\/j.1365-2133.1998.02118.x","article-title":"Sun exposure and large numbers of common and atypical melanocytic naevi: an analytical study in a southern European population","volume":"138","author":"Carli","year":"1998","journal-title":"Br J Dermatol"},{"issue":"5","key":"2021120823464668800_B3","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1111\/1523-1747.ep12374298","article-title":"Associated factors in the prevalence of more than 50 common melanocytic nevi, atypical melanocytic nevi, and actinic lentigines: multicenter case-control study of the Central Malignant Melanoma Registry of the German Dermatological Society","volume":"102","author":"Garbe","year":"1994","journal-title":"J Invest Dermatol"},{"issue":"3","key":"2021120823464668800_B4","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1093\/oxfordjournals.aje.a008735","article-title":"Constitutional factors and sun exposure in relation to nevi: a population-based cross-sectional study","volume":"143","author":"Dennis","year":"1996","journal-title":"Am J Epidemiol"},{"issue":"6","key":"2021120823464668800_B5","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1016\/S0190-9622(89)70131-6","article-title":"Melanocytic nevi in schoolchildren in Queensland","volume":"20","author":"Green","year":"1989","journal-title":"J Am Acad Dermatol"},{"issue":"5","key":"2021120823464668800_B6","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1067\/mjd.2002.120931","article-title":"Longitudinal study of melanocytic nevi in adolescents","volume":"46","author":"Darlington","year":"2002","journal-title":"J Am Acad Dermatol"},{"issue":"6","key":"2021120823464668800_B7","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1001\/archderm.1990.01670300070010","article-title":"Suntan, sunburn, and pigmentation factors and the frequency of acquired melanocytic nevi in children. 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