{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T11:49:45Z","timestamp":1791805785343,"version":"4.3.4"},"reference-count":15,"publisher":"American Academy of Pediatrics (AAP)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,12,1]]},"abstract":"<jats:p>Standard pharmacologic closure of the patent ductus arteriosus currently involves the administration of 1 of 2 cyclooxygenase inhibitors: either indomethacin or ibuprofen. However, both of these drugs can be associated with potentially significant adverse effects. We present here the cases of 5 preterm infants (gestational age: 26\u201332 weeks; postnatal age: 3\u201335 days) with large, hemodynamically significant patent ductus arteriosus who had either failed or had contraindications to ibuprofen therapy. Each of these infants was treated with off-label oral paracetamol (15 mg\/kg per dose every 6 hours). Ductal closure was achieved within 48 hours in all the treated infants. No toxicity was observed.<\/jats:p>","DOI":"10.1542\/peds.2011-0359","type":"journal-article","created":{"date-parts":[[2011,11,8]],"date-time":"2011-11-08T01:56:43Z","timestamp":1320717403000},"page":"e1618-e1621","source":"Crossref","is-referenced-by-count":186,"title":["Ductal Closure With Paracetamol: A Surprising New Approach to Patent Ductus Arteriosus Treatment"],"prefix":"10.1542","volume":"128","author":[{"given":"Cathy","family":"Hammerman","sequence":"first","affiliation":[{"name":"Departments of Neonatology and"},{"name":"Faculty of Medicine, Hebrew University, Jerusalem, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alona","family":"Bin-Nun","sequence":"additional","affiliation":[{"name":"Departments of Neonatology and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Einat","family":"Markovitch","sequence":"additional","affiliation":[{"name":"Departments of Neonatology and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael S.","family":"Schimmel","sequence":"additional","affiliation":[{"name":"Departments of Neonatology and"},{"name":"Faculty of Medicine, Hebrew University, Jerusalem, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Kaplan","sequence":"additional","affiliation":[{"name":"Departments of Neonatology and"},{"name":"Faculty of Medicine, Hebrew University, Jerusalem, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Fink","sequence":"additional","affiliation":[{"name":"Pediatric Cardiology, Shaare Zedek Medical Center, Jerusalem, Israel; 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