{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T08:56:49Z","timestamp":1762505809294,"version":"3.40.5"},"reference-count":27,"publisher":"American Academy of Pediatrics (AAP)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,9,1]]},"abstract":"<jats:sec>\n                  <jats:title>OBJECTIVE:<\/jats:title>\n                  <jats:p>The goal of this study was to evaluate urinary N-terminal fragment of B-type natriuretic peptide concentrations, normalized to creatinine (UNBCR), to predict morbidities at discharge in preterm infants.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS:<\/jats:title>\n                  <jats:p>UNBCR were determined in urine collected on day of life (DOL) 2, 7, 14, and 28 in 136 preterm infants &amp;lt;1500 g birth weight, 22 of whom developed bronchopulmonary dysplasia (BPD), defined as oxygen supplementation at 36 weeks' gestational age) and 11 infants developed severe retinopathy (ROP), defined as stage 3 or stage \u22652 requiring surgery).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS:<\/jats:title>\n                  <jats:p>UNBCR on DOL 7, 14, and 28 was elevated in infants who developed BPD or ROP compared with controls (P \u2264 .001). On multiple regression analysis including birth weight and gestational age, ROP but not BPD remained independently associated with UNBCR on DOL 14 and 28. Areas under receiver operating characteristic curves for UNBCR on DOL 14 and 28 to predict ROP were 0.938 (0.027) and 0.954 (0.021), respectively. UNBCR DOL 14 and 28 thresholds exceeded by all infants with severe ROP (100% sensitivity, 100% negative predictive value) had a specificity of 66% and 85%, respectively.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS:<\/jats:title>\n                  <jats:p>UNBCR might hold promise to reduce unnecessary eye examinations by timely and accurate identification of infants at risk of severe ROP.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1542\/peds.2011-0603","type":"journal-article","created":{"date-parts":[[2011,8,9]],"date-time":"2011-08-09T02:23:49Z","timestamp":1312856629000},"page":"e545-e549","source":"Crossref","is-referenced-by-count":30,"title":["Urinary N-Terminal B-Type Natriuretic Peptide Predicts Severe Retinopathy of Prematurity"],"prefix":"10.1542","volume":"128","author":[{"given":"Christoph","family":"Czernik","sequence":"first","affiliation":[{"name":"Department of Neonatology;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Boris","family":"Metze","sequence":"additional","affiliation":[{"name":"Department of Neonatology;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"M\u00fcller","sequence":"additional","affiliation":[{"name":"Institute of Laboratory Medicine; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bert","family":"M\u00fcller","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Charit\u00e9 University Medical Center, Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christoph","family":"B\u00fchrer","sequence":"additional","affiliation":[{"name":"Department of Neonatology;"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"417","published-online":{"date-parts":[[2011,9,1]]},"reference":[{"issue":"5","key":"2021120823452406800_B1","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1111\/j.1651-2227.2004.tb02984.x","article-title":"N-terminal pro-B-type natriuretic peptide: reference plasma levels from birth to adolescence. Elevated levels at birth and in infants and children with heart diseases","volume":"93","author":"Nir","year":"2004","journal-title":"Acta Paediatr"},{"issue":"6","key":"2021120823452406800_B2","doi-asserted-by":"crossref","first-page":"F407","DOI":"10.1136\/adc.2007.133140","article-title":"Biochemical markers may identify preterm infants with a patent ductus arteriosus at high risk of death or severe intraventricular haemorrhage","volume":"93","author":"El-Khuffash","year":"2008","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"issue":"5","key":"2021120823452406800_B3","doi-asserted-by":"crossref","first-page":"F421","DOI":"10.1136\/adc.2007.119701","article-title":"N-terminal pro-B-type natriuretic peptide as a marker of ductal haemodynamic significance in preterm infants: a prospective observational study","volume":"92","author":"El-Khuffash","year":"2007","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"issue":"4","key":"2021120823452406800_B4","doi-asserted-by":"crossref","first-page":"F257","DOI":"10.1136\/adc.2007.120691","article-title":"N-terminal pro-B-type natriuretic peptide: a measure of significant patent ductus arteriosus","volume":"93","author":"Farombi-Oghuvbu","year":"2008","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"issue":"5","key":"2021120823452406800_B5","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1055\/s-0029-1243312","article-title":"N-terminal pro-B-type natriuretic peptide as a marker of bronchopulmonary dysplasia in premature infants","volume":"27","author":"Joseph","year":"2010","journal-title":"Am J Perinatol"},{"key":"2021120823452406800_B6","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/0140-6736(93)92296-6","article-title":"The CRIB (clinical risk index for babies) score: a tool for assessing initial neonatal risk and comparing performance of neonatal intensive care units. The International Neonatal Network","volume":"342","year":"1993","journal-title":"Lancet"},{"issue":"10","key":"2021120823452406800_B7","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1164\/rccm.200611-1660PP","article-title":"Bronchopulmonary dysplasia: where have all the vessels gone? Roles of angiogenic growth factors in chronic lung disease","volume":"175","author":"Th\u00e9baud","year":"2007","journal-title":"Am J Respir Crit Care Med"},{"issue":"5","key":"2021120823452406800_B8","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1159\/000242497","article-title":"Pathogenesis of bronchopulmonary dysplasia","volume":"79","author":"Hayes","year":"2010","journal-title":"Respiration"},{"issue":"9","key":"2021120823452406800_B9","doi-asserted-by":"crossref","first-page":"3022","DOI":"10.1172\/JCI42142","article-title":"Retinopathy of prematurity: understanding ischemic retinal vasculopathies at an extreme of life","volume":"120","author":"Sapieha","year":"2010","journal-title":"J Clin Invest"},{"issue":"4","key":"2021120823452406800_B10","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1542\/peds.2008-0862","article-title":"Patterns of respiratory disease during the first 2 postnatal weeks in extremely premature infants","volume":"123","author":"Laughon","year":"2009","journal-title":"Pediatrics"},{"issue":"4","key":"2021120823452406800_B11","doi-asserted-by":"crossref","first-page":"1578","DOI":"10.1210\/endo.142.4.8099","article-title":"Natriuretic peptides suppress vascular endothelial cell growth factor signaling to angiogenesis","volume":"142","author":"Pedram","year":"2001","journal-title":"Endocrinology"},{"issue":"6","key":"2021120823452406800_B12","doi-asserted-by":"crossref","first-page":"2343","DOI":"10.2353\/ajpath.2009.090439","article-title":"Atrial natriuretic peptide reduces vascular leakage and choroidal neovascularization","volume":"175","author":"Lara-Castillo","year":"2009","journal-title":"Am J Pathol"},{"issue":"7","key":"2021120823452406800_B13","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1136\/bjo.82.7.830","article-title":"Brain natriuretic peptide: identification of a second natriuretic peptide in human aqueous humour","volume":"82","author":"Salzmann","year":"1998","journal-title":"Br J Ophthalmol"},{"key":"2021120823452406800_B14","first-page":"15","article-title":"Natriuretic peptide system in the human retina","volume":"10","author":"Roll\u00edn","year":"2004","journal-title":"Mol Vis"},{"key":"2021120823452406800_B15","first-page":"1241","article-title":"NPR-B natriuretic peptide receptors in human corneal epithelium: mRNA, immunohistochemistochemical, protein, and biochemical pharmacology studies","volume":"16","author":"Katoli","year":"2010","journal-title":"Mol Vis"},{"issue":"6","key":"2021120823452406800_B16","doi-asserted-by":"crossref","first-page":"F419","DOI":"10.1136\/adc.2009.180943","article-title":"Sweeten, soother and swaddle for retinopathy of prematurity screening: a randomised placebo controlled trial","volume":"95","author":"O'Sullivan","year":"2010","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"issue":"2","key":"2021120823452406800_B17","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1542\/peds.2005-2749","article-title":"Screening examination of premature infants for retinopathy of prematurity","volume":"117","year":"2006","journal-title":"Pediatrics"},{"key":"2021120823452406800_B18","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1891\/0730-0832.29.3.143","article-title":"The retinopathy of prematurity screening examination: ensuring a safe and efficient examination while minimizing infant discomfort","volume":"29","author":"Hered","year":"2010","journal-title":"Neonatal Netw"},{"key":"2021120823452406800_B19","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1097\/00006982-200404000-00009","article-title":"Systemic manifestations in response to mydriasis and physical examination during screening for retinopathy of prematurity","volume":"24","author":"Rush","year":"2004","journal-title":"Retina"},{"issue":"2","key":"2021120823452406800_B20","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1159\/000280386","article-title":"Incidence of retinopathy of prematurity over the last decade in the Central Netherlands","volume":"98","author":"Hoogerwerf","year":"2010","journal-title":"Neonatology"},{"issue":"6","key":"2021120823452406800_B21","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1007\/s00417-009-1248-6","article-title":"The influence of gestational age on the dynamic behavior of other risk factors associated with retinopathy of prematurity (ROP)","volume":"248","author":"Fortes Filho","year":"2010","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"issue":"6","key":"2021120823452406800_B22","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/j.jaapos.2009.10.002","article-title":"Risk analysis and an alternative protocol for reduction of screening for retinopathy of prematurity","volume":"13","author":"Yang","year":"2009","journal-title":"J AAPOS"},{"issue":"12","key":"2021120823452406800_B23","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.1136\/bjo.2010.180307","article-title":"Retinopathy of prematurity: keeping the status quo. A case series detailing the importance of keeping the current guidelines for screening","volume":"94","author":"Durnian","year":"2010","journal-title":"Br J Ophthalmol"},{"issue":"4","key":"2021120823452406800_B24","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1177\/112067211002000417","article-title":"Retinopathy of prematurity: screening guidelines need to be reevaluated for developing countries","volume":"20","author":"Basmak","year":"2010","journal-title":"Eur J Ophthalmol"},{"issue":"4","key":"2021120823452406800_B25","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1111\/j.1651-2227.2009.01568.x","article-title":"New insights into the development of retinopathy of prematurity\u2014importance of early weight gain","volume":"99","author":"Hellstr\u00f6m","year":"2010","journal-title":"Acta Paediatr"},{"issue":"4","key":"2021120823452406800_B26","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1001\/archophthalmol.2010.31","article-title":"Longitudinal postnatal weight measurements for the prediction of retinopathy of prematurity","volume":"128","author":"Wu","year":"2010","journal-title":"Arch Ophthalmol"},{"issue":"11","key":"2021120823452406800_B27","doi-asserted-by":"crossref","first-page":"1432","DOI":"10.1001\/archophthalmol.2010.255","article-title":"Predicting proliferative retinopathy in a Brazilian population of preterm infants with the screening algorithm WINROP","volume":"128","author":"H\u00e5rd","year":"2010","journal-title":"Arch Ophthalmol"}],"container-title":["Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/publications.aap.org\/pediatrics\/article-pdf\/128\/3\/e545\/845501\/zpe0091100e545.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/publications.aap.org\/pediatrics\/article-pdf\/128\/3\/e545\/845501\/zpe0091100e545.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,9]],"date-time":"2021-12-09T04:56:58Z","timestamp":1639025818000},"score":1,"resource":{"primary":{"URL":"https:\/\/publications.aap.org\/pediatrics\/article\/128\/3\/e545\/30710\/Urinary-N-Terminal-B-Type-Natriuretic-Peptide"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,9,1]]},"references-count":27,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2011,9,1]]},"published-print":{"date-parts":[[2011,9,1]]}},"URL":"https:\/\/doi.org\/10.1542\/peds.2011-0603","relation":{},"ISSN":["0031-4005","1098-4275"],"issn-type":[{"type":"print","value":"0031-4005"},{"type":"electronic","value":"1098-4275"}],"subject":[],"published":{"date-parts":[[2011,9,1]]}}}