{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T09:11:59Z","timestamp":1791191519443,"version":"4.1.0"},"reference-count":82,"publisher":"American Academy of Pediatrics (AAP)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,4,1]]},"abstract":"<jats:sec>\n                    <jats:title>OBJECTIVE:<\/jats:title>\n                    <jats:p>To contrast the behavioral and social phenotypes including a screen for autistic behaviors in boys with 47,XYY syndrome (XYY) or 47,XXY Klinefelter syndrome (KS) and controls and investigate the effect of prenatal diagnosis on the phenotype.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>Patients included 26 boys with 47,XYY, 82 boys with KS, and 50 control boys (ages 4\u201315 years). Participants and parents completed a physical examination, behavioral questionnaires, and intellectual assessments.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>Most boys with XYY or KS had Child Behavior Checklist parental ratings within the normal range. On the Child Behavior Checklist, mean problem behaviors t scores were higher in the XYY versus KS groups for the Problem Behavior, Externalizing, Withdrawn, Thought Problems, and Attention Problems subscales. On the Conners\u2019 Parent Rating Scale\u2013Revised, the XYY versus KS group had increased frequency of hyperactive\/impulsive symptoms (P &amp;lt; .006). In addition, 50% and 12% of the XYY and KS groups, respectively, had scores &amp;gt;15 for autism screening from the Social Communication Questionnaire. For the boys with KS, prenatal diagnosis was associated with fewer problem behaviors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>A subset of the XYY and KS groups had behavioral difficulties that were more severe in the XYY group. These findings could guide clinical practice and inform patients and parents. Boys diagnosed with XYY or KS should receive a comprehensive psychoeducational evaluation and be screened for learning disabilities, attention-deficit\/hyperactivity disorder, and autism spectrum disorders.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1542\/peds.2011-0719","type":"journal-article","created":{"date-parts":[[2012,3,12]],"date-time":"2012-03-12T20:30:43Z","timestamp":1331584243000},"page":"769-778","source":"Crossref","is-referenced-by-count":164,"title":["Behavioral and Social Phenotypes in Boys With 47,XYY Syndrome or 47,XXY Klinefelter Syndrome"],"prefix":"10.1542","volume":"129","author":[{"given":"Judith L.","family":"Ross","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Thomas Jefferson University, Philadelphia, Pennsylvania;"},{"name":"A. I. duPont Hospital for Children, Wilmington, Delaware;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David P.","family":"Roeltgen","sequence":"additional","affiliation":[{"name":"Department of Neurology, Georgetown, Washington, District of Columbia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harvey","family":"Kushner","sequence":"additional","affiliation":[{"name":"Biomedical Computer Research Institute, Philadelphia, Pennsylvania;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew R.","family":"Zinn","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center, Dallas, Texas;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allan","family":"Reiss","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Stanford University, Palo Alto, California;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martha Zeger","family":"Bardsley","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Thomas Jefferson University, Philadelphia, Pennsylvania;"},{"name":"A. I. duPont Hospital for Children, Wilmington, Delaware;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"McCauley","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of Washington, Seattle, Washington; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Tartaglia","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Colorado School of Medicine, Children\u2019s Hospital Colorado, Aurora, Colorado"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"417","published-online":{"date-parts":[[2012,4,1]]},"reference":[{"issue":"5","key":"2021120903544569300_B1","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1002\/ajmg.1320600503","article-title":"Intelligence and achievement in children with extra X aneuploidy: a longitudinal perspective.","volume":"60","author":"Rovet","year":"1995","journal-title":"Am J Med 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