{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,8]],"date-time":"2025-05-08T13:24:28Z","timestamp":1746710668313,"version":"3.40.5"},"reference-count":19,"publisher":"American Academy of Pediatrics (AAP)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,7,1]]},"abstract":"<jats:p>Adolescents with well-controlled cystic fibrosis, including good lung function and appropriate growth, commonly participate in competitive athletic activities. We present the case of an adolescent male with cystic fibrosis, hyponatremia, dehydration, and rhabdomyolysis after participating in football practice on a summer morning. The patient presented with severe myalgia and serum sodium of 129 mmol\/L, chloride 90 mmol\/L, and creatine phosphokinase 1146 U\/L. Aggressive hydration with intravenous 0.9% saline resulted in clinical improvement with no renal or muscular sequelae. Health care providers need to educate patients with cystic fibrosis about maintaining adequate hydration and sodium repletion during exercise. Research is needed regarding the appropriate amount and composition of oral rehydration fluids in exercising individuals with cystic fibrosis, as the physiology encountered in these patients provides a unique challenge to maintaining electrolyte balance and stimulation of thirst.<\/jats:p>","DOI":"10.1542\/peds.2011-1200","type":"journal-article","created":{"date-parts":[[2012,6,5]],"date-time":"2012-06-05T09:47:46Z","timestamp":1338889666000},"page":"e220-e223","source":"Crossref","is-referenced-by-count":7,"title":["Hyponatremia-Associated Rhabdomyolysis Following Exercise in an Adolescent With Cystic Fibrosis"],"prefix":"10.1542","volume":"130","author":[{"given":"Jillian","family":"Kaskavage","sequence":"first","affiliation":[{"name":"Department of Pediatrics, University of Illinois College of Medicine at Rockford, Rockford, Illinois"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Sklansky","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Illinois College of Medicine at Rockford, Rockford, Illinois"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"417","published-online":{"date-parts":[[2012,7,1]]},"reference":[{"issue":"3","key":"2021120821033036000_B1","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1097\/01823246-200819030-00002","article-title":"The evidence regarding exercise training in the management of cystic fibrosis: a systematic review.","volume":"19","author":"Shoemaker","year":"2008","journal-title":"Cardiopulm Phys Ther J"},{"issue":"1","key":"2021120821033036000_B2","doi-asserted-by":"crossref","first-page":"41","DOI":"10.3109\/09638280902991842","article-title":"Exercise programs for children with cystic fibrosis: a systematic review of randomized controlled trials.","volume":"32","author":"van Doorn","year":"2010","journal-title":"Disabil Rehabil"},{"issue":"5","key":"2021120821033036000_B3","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.jcf.2010.05.006","article-title":"Risks associated with exercise testing and sports participation in cystic fibrosis.","volume":"9","author":"Ruf","year":"2010","journal-title":"J Cyst Fibros"},{"issue":"3","key":"2021120821033036000_B4","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1159\/000045413","article-title":"Hyponatremia-associated rhabdomyolysis.","volume":"82","author":"Trimarchi","year":"1999","journal-title":"Nephron"},{"issue":"2","key":"2021120821033036000_B5","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.genhosppsych.2006.12.001","article-title":"Recurrent rhabdomyolysis associated with polydipsia-induced hyponatremia\u2014a case report and review of the literature.","volume":"29","author":"Strachan","year":"2007","journal-title":"Gen Hosp Psychiatry"},{"issue":"8795","key":"2021120821033036000_B6","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1016\/0140-6736(92)90597-V","article-title":"Voluntary dehydration and heat intolerance in cystic fibrosis.","volume":"339","author":"Bar-Or","year":"1992","journal-title":"Lancet"},{"issue":"6","key":"2021120821033036000_B7","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1097\/00005768-199906000-00003","article-title":"Preventing dehydration in children with cystic fibrosis who exercise in the heat.","volume":"31","author":"Kriemler","year":"1999","journal-title":"Med Sci Sports Exerc"},{"issue":"2","key":"2021120821033036000_B8","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/S0272-6386(12)81095-X","article-title":"Transient exercise-induced water intoxication and rhabdomyolysis.","volume":"21","author":"Putterman","year":"1993","journal-title":"Am J Kidney Dis"},{"issue":"1","key":"2021120821033036000_B9","doi-asserted-by":"crossref","first-page":"126","DOI":"10.3810\/PSM.2009.04.1693","article-title":"Case report: exercise-associated hyponatremia with rhabdomyolysis during endurance exercise.","volume":"37","author":"Ellis","year":"2009","journal-title":"Phys Sportsmed"},{"issue":"1","key":"2021120821033036000_B10","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1007\/s00467-009-1223-9","article-title":"Rhabdomyolysis: a review, with emphasis on the pediatric population.","volume":"25","author":"Elsayed","year":"2010","journal-title":"Pediatr Nephrol"},{"issue":"7","key":"2021120821033036000_B11","doi-asserted-by":"crossref","first-page":"S74","DOI":"10.1016\/j.amjmed.2006.05.012","article-title":"Exercise-associated hyponatremia: role of cytokines.","volume":"119","author":"Siegel","year":"2006","journal-title":"Am J Med"},{"key":"2021120821033036000_B12","first-page":"1006","volume-title":"Pediatric Nutrition Handbook","author":"Nutrition in cystic fibrosis","year":"2009","edition":"6th ed."},{"key":"2021120821033036000_B13","unstructured":"Baker RD, Coburn-Miller C, Baker SS. 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