{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T14:34:06Z","timestamp":1791297246444,"version":"4.1.0"},"reference-count":18,"publisher":"American Academy of Pediatrics (AAP)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,1,1]]},"abstract":"<jats:sec>\n                  <jats:title>Background and Objectives:<\/jats:title>\n                  <jats:p>Children with sickle cell disease are considered at high risk for complications from influenza infection and are recommended to receive annual influenza vaccination. However, data on the safety of influenza vaccination in children with sickle cell anemia are sparse.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods:<\/jats:title>\n                  <jats:p>Using a retrospective cohort of children aged 6 months to 17 years in 8 managed care organizations that comprise the Vaccine Safety Datalink and who had a diagnosis of sickle cell anemia from 1999 to 2006, we conducted matched case-control and self-controlled case series studies to examine the association of trivalent inactivated influenza vaccination with hospitalization for sickle cell crisis in the 2 weeks after vaccination.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results:<\/jats:title>\n                  <jats:p>From an original pool of 1085 pediatric subjects with a diagnosis of sickle cell anemia, we identified 179 children with at least 1 sickle cell crisis during any influenza season (October 1\u2013March 31). In the matched case-control study (matching on age category, gender, Vaccine Safety Datalink site, and season), the odds ratio of hospitalization for a crisis in vaccinated compared with unvaccinated children was not significant: 1.3 (95% confidence interval 0.8\u20132.2). In the self-controlled case series study of hospitalized cases, the incident rate ratio for hospitalization with sickle cell crisis in the 2 weeks after trivalent inactivated influenza vaccination was also not significant: 1.2 (95% confidence interval 0.75\u20131.95).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions:<\/jats:title>\n                  <jats:p>This large cohort study did not find an association of influenza vaccination and hospitalization for sickle cell crises in children with sickle cell anemia.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1542\/peds.2011-1294","type":"journal-article","created":{"date-parts":[[2011,12,13]],"date-time":"2011-12-13T02:11:45Z","timestamp":1323742305000},"page":"e54-e59","source":"Crossref","is-referenced-by-count":17,"title":["Trivalent Inactivated Influenza Vaccine Is Not Associated With Sickle Cell Crises in Children"],"prefix":"10.1542","volume":"129","author":[{"given":"Simon J.","family":"Hambidge","sequence":"first","affiliation":[{"name":"Institute for Health Research, Kaiser Permanente Colorado, Denver, Colorado"},{"name":"Department Community Health Services, Denver Health, Denver, Colorado"},{"name":"Departments of Pediatrics,"},{"name":"Epidemiology, University of Colorado School of Public Health, Aurora, Colorado"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colleen","family":"Ross","sequence":"additional","affiliation":[{"name":"Institute for Health Research, Kaiser Permanente Colorado, Denver, Colorado"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason","family":"Glanz","sequence":"additional","affiliation":[{"name":"Institute for Health Research, Kaiser Permanente Colorado, Denver, Colorado"},{"name":"Epidemiology, University of Colorado School of Public Health, Aurora, Colorado"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"McClure","sequence":"additional","affiliation":[{"name":"Institute for Health Research, Kaiser Permanente Colorado, Denver, Colorado"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew F.","family":"Daley","sequence":"additional","affiliation":[{"name":"Institute for Health Research, Kaiser Permanente Colorado, Denver, Colorado"},{"name":"Departments of Pediatrics,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stan","family":"Xu","sequence":"additional","affiliation":[{"name":"Institute for Health Research, Kaiser Permanente Colorado, Denver, Colorado"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo Ann","family":"Shoup","sequence":"additional","affiliation":[{"name":"Institute for Health Research, Kaiser Permanente Colorado, Denver, 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