{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T04:09:51Z","timestamp":1785816591677,"version":"3.56.0"},"reference-count":32,"publisher":"American Academy of Pediatrics (AAP)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,3,1]]},"abstract":"<jats:sec>\n                  <jats:title>BACKGROUND AND OBJECTIVE:<\/jats:title>\n                  <jats:p>As atherosclerosis is a lifelong process, prevention of exposure to its risk factors should start at an early age. Our aim was to study the influences of repeated low saturated fat dietary counseling on dietary intakes and lipoprotein measures from infancy to adulthood.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS:<\/jats:title>\n                  <jats:p>Dietary intakes (food records) and serum lipid profile were studied annually from 7 months to 19 years of age in an atherosclerosis prevention study (Special Turku Coronary Risk Factor Intervention Project), comprising 540 children in the intervention group and 522 children in the control group. Serum total and high-density lipoprotein cholesterol (HDL-C), and triglycerides (TG) were measured and used to estimate very low-density lipoprotein\u2013TG, intermediate-density lipoprotein cholesterol, low-density lipoprotein cholesterol, and HDL2-C, as well as apolipoproteins A-1 and B.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS:<\/jats:title>\n                  <jats:p>Compared with controls, the intervention children had a lower saturated fat intake (mean daily difference [95% confidence interval] between groups: \u22122.1 [\u22122.3, \u22121.9] percentage of total energy intake in boys; \u22121.9 [\u22122.1, \u22121.7] percentage of total energy intake in girls, both P &amp;lt; .001) and LDL-C concentration (difference [95% confidence interval] between groups: \u22120.18 [\u22120.26, \u22120.10] mmol\/L, P &amp;lt; .001 in boys; \u22120.10 [\u22120.19, \u22120.01] mmol\/L, P = .037 in girls), whereas HDL-C and apolipoprotein A-1 did not differ between the study groups. In boys, total cholesterol and intermediate-density lipoprotein cholesterol, very low-density lipoprotein\u2013TG, apolipoprotein B, and TG concentrations were also lower in the intervention than in the control group, whereas no differences were found in girls.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS:<\/jats:title>\n                  <jats:p>Repeated dietary counseling is effective in decreasing saturated fat intake and serum LDL-C values from infancy until 19 years of age in both genders. In boys, significant intervention effects are evident in various lipoprotein measures, indicating a more favorable lipid profile in the counseling group.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1542\/peds.2011-1503","type":"journal-article","created":{"date-parts":[[2012,2,14]],"date-time":"2012-02-14T01:25:38Z","timestamp":1329182738000},"page":"e704-e713","source":"Crossref","is-referenced-by-count":62,"title":["Effect of Repeated Dietary Counseling on Serum Lipoproteins From Infancy to Adulthood"],"prefix":"10.1542","volume":"129","author":[{"given":"Harri","family":"Niinikoski","sequence":"first","affiliation":[{"name":"Departments of Pediatrics,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katja","family":"Pahkala","sequence":"additional","affiliation":[{"name":"Research Centre of Applied and Preventive Cardiovascular Medicine,"},{"name":"Paavo Nurmi Centre, Sports & Exercise Medicine Unit, Department of Physiology, University of Turku, Turku, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mika","family":"Ala-Korpela","sequence":"additional","affiliation":[{"name":"Computational Medicine Research Group, Institute of Clinical Medicine, and Department of Internal Medicine, Clinical Research Center, University of Oulu & Biocenter Oulu, Oulu, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorma","family":"Viikari","sequence":"additional","affiliation":[{"name":"Medicine, University of Turku and Turku University Hospital, Turku, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tapani","family":"R\u00f6nnemaa","sequence":"additional","affiliation":[{"name":"Medicine, University of Turku and Turku University Hospital, Turku, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanna","family":"Lagstr\u00f6m","sequence":"additional","affiliation":[{"name":"Turku Institute for Child and Youth Research, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eero","family":"Jokinen","sequence":"additional","affiliation":[{"name":"Hospital for Children and Adolescents, University of Helsinki, Helsinki, Finland; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antti","family":"Jula","sequence":"additional","affiliation":[{"name":"Institute for Health and Welfare, Turku, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markku J.","family":"Savolainen","sequence":"additional","affiliation":[{"name":"Computational Medicine Research Group, Institute of Clinical Medicine, and Department of Internal Medicine, Clinical Research Center, University of Oulu & Biocenter Oulu, Oulu, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olli","family":"Simell","sequence":"additional","affiliation":[{"name":"Departments of Pediatrics,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olli T.","family":"Raitakari","sequence":"additional","affiliation":[{"name":"Research Centre of Applied and Preventive Cardiovascular Medicine,"},{"name":"Clinical Physiology, and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"417","published-online":{"date-parts":[[2012,3,1]]},"reference":[{"issue":"9","key":"2021120903015272500_B1","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1161\/CIRCULATIONAHA.107.723817","article-title":"Diet and primordial prevention of cardiovascular disease in children and adolescents","volume":"116","author":"Daniels","year":"2007","journal-title":"Circulation"},{"issue":"3","key":"2021120903015272500_B2","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1056\/NEJM198601163140302","article-title":"Relation of serum lipoprotein levels and systolic blood pressure to early atherosclerosis. The Bogalusa Heart Study","volume":"314","author":"Newman","year":"1986","journal-title":"N Engl J Med"},{"issue":"23","key":"2021120903015272500_B3","doi-asserted-by":"crossref","first-page":"3018","DOI":"10.1001\/jama.1990.03450230054029","article-title":"Relationship of atherosclerosis in young men to serum lipoprotein cholesterol concentrations and smoking. A preliminary report from the Pathobiological Determinants of Atherosclerosis in Youth (PDAY) Research Group","volume":"264","year":"1990","journal-title":"JAMA"},{"issue":"17","key":"2021120903015272500_B4","doi-asserted-by":"crossref","first-page":"2271","DOI":"10.1001\/jama.290.17.2271","article-title":"Childhood cardiovascular risk factors and carotid vascular changes in adulthood: the Bogalusa Heart Study","volume":"290","author":"Li","year":"2003","journal-title":"JAMA"},{"issue":"17","key":"2021120903015272500_B5","doi-asserted-by":"crossref","first-page":"2277","DOI":"10.1001\/jama.290.17.2277","article-title":"Cardiovascular risk factors in childhood and carotid artery intima-media thickness in adulthood: the Cardiovascular Risk in Young Finns Study","volume":"290","author":"Raitakari","year":"2003","journal-title":"JAMA"},{"issue":"8948","key":"2021120903015272500_B6","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/S0140-6736(95)90580-4","article-title":"Prospective randomised trial in 1062 infants of diet low in saturated fat and cholesterol","volume":"345","author":"Lapinleimu","year":"1995","journal-title":"Lancet"},{"issue":"3","key":"2021120903015272500_B7","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1093\/ije\/dyn072","article-title":"Cohort profile: the STRIP Study (Special Turku Coronary Risk Factor Intervention Project), an Infancy-onset Dietary and Life-style Intervention Trial","volume":"38","author":"Simell","year":"2009","journal-title":"Int J Epidemiol"},{"issue":"9","key":"2021120903015272500_B8","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1161\/CIRCULATIONAHA.107.699447","article-title":"Impact of repeated dietary counseling between infancy and 14 years of age on dietary intakes and serum lipids and lipoproteins: the STRIP study","volume":"116","author":"Niinikoski","year":"2007","journal-title":"Circulation"},{"issue":"6","key":"2021120903015272500_B9","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1161\/HYPERTENSIONAHA.109.130146","article-title":"Blood pressure is lower in children and adolescents with a low-saturated-fat diet since infancy: the special Turku Coronary Risk Factor Intervention Project","volume":"53","author":"Niinikoski","year":"2009","journal-title":"Hypertension"},{"issue":"24","key":"2021120903015272500_B10","doi-asserted-by":"crossref","first-page":"3786","DOI":"10.1161\/CIRCULATIONAHA.105.583195","article-title":"Endothelial function in healthy 11-year-old children after dietary intervention with onset in infancy: the Special Turku Coronary Risk Factor Intervention Project for children (STRIP)","volume":"112","author":"Raitakari","year":"2005","journal-title":"Circulation"},{"issue":"8","key":"2021120903015272500_B11","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1001\/jama.284.8.993","article-title":"Neurological development of 5-year-old children receiving a low-saturated fat, low-cholesterol diet since infancy: a randomized controlled trial","volume":"284","author":"Rask-Nissil\u00e4","year":"2000","journal-title":"JAMA"},{"issue":"13","key":"2021120903015272500_B12","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.1161\/01.CIR.102.13.1477","article-title":"Prospective, randomized, infancy-onset trial of the effects of a low-saturated-fat, low-cholesterol diet on serum lipids and lipoproteins before school age: the Special Turku Coronary Risk Factor Intervention Project (STRIP)","volume":"102","author":"Rask-Nissil\u00e4","year":"2000","journal-title":"Circulation"},{"issue":"6","key":"2021120903015272500_B13","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1093\/clinchem\/18.6.499","article-title":"Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge","volume":"18","author":"Friedewald","year":"1972","journal-title":"Clin Chem"},{"issue":"6","key":"2021120903015272500_B14","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1080\/07853890902893392","article-title":"Estimation of VLDL, IDL, LDL, HDL2, apoA-I, and apoB from the Friedewald inputs\u2014apoB and IDL, but not LDL, are associated with mortality in type 1 diabetes","volume":"41","author":"Niemi","year":"2009","journal-title":"Ann Med"},{"issue":"6","key":"2021120903015272500_B15","doi-asserted-by":"crossref","first-page":"2762","DOI":"10.1161\/01.CIR.88.6.2762","article-title":"Plasma lipoproteins and progression of coronary artery disease evaluated by angiography and clinical events","volume":"88","author":"Phillips","year":"1993","journal-title":"Circulation"},{"issue":"3","key":"2021120903015272500_B16","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1161\/01.CIR.94.3.273","article-title":"Apolipoprotein A-1 and B levels and the risk of ischemic heart disease during a five-year follow-up of men in the Qu\u00e9bec cardiovascular study","volume":"94","author":"Lamarche","year":"1996","journal-title":"Circulation"},{"issue":"9634","key":"2021120903015272500_B17","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/S0140-6736(08)61076-4","article-title":"Lipids, lipoproteins, and apolipoproteins as risk markers of myocardial infarction in 52 countries (the INTERHEART study): a case-control study","volume":"372","author":"McQueen","year":"2008","journal-title":"Lancet"},{"issue":"4","key":"2021120903015272500_B18","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.jacc.2008.03.054","article-title":"Childhood levels of serum apolipoproteins B and A-1 predict carotid intima-media thickness and brachial endothelial function in adulthood: the cardiovascular risk in young Finns study","volume":"52","author":"Juonala","year":"2008","journal-title":"J Am Coll Cardiol"},{"key":"2021120903015272500_B19"},{"issue":"1","key":"2021120903015272500_B20","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/0308-8146(96)00077-5","article-title":"Calculated vs. analysed nutrient composition of weight reduction diets","volume":"57","author":"Hakala","year":"1996","journal-title":"Food Chem"},{"issue":"5","key":"2021120903015272500_B21","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1093\/clinchem\/22.5.695a","article-title":"Enzymatic determination of cholesterol in high-density lipoprotein fractions prepared by polyanion precipitation [letter]","volume":"22","author":"Kostner","year":"1976","journal-title":"Clin Chem"},{"issue":"8476","key":"2021120903015272500_B22","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/S0140-6736(86)90837-8","article-title":"Statistical methods for assessing agreement between two methods of clinical measurement","volume":"1","author":"Bland","year":"1986","journal-title":"Lancet"},{"issue":"1","key":"2021120903015272500_B23","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1038\/sj.ejcn.1601120","article-title":"Associations between dietary intakes and blood cholesterol concentrations at 31 months","volume":"55","author":"Cowin","year":"2001","journal-title":"Eur J Clin Nutr"},{"issue":"1","key":"2021120903015272500_B24","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1001\/archpedi.158.1.41","article-title":"A randomized intervention since infancy to reduce intake of saturated fat: calorie (energy) and nutrient intakes up to the age of 10 years in the Special Turku Coronary Risk Factor Intervention Project","volume":"158","author":"Talvia","year":"2004","journal-title":"Arch Pediatr Adolesc Med"},{"issue":"7","key":"2021120903015272500_B25","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/0026-0495(65)90001-6","article-title":"Serum cholesterol response to changes in diet. 1. Iodine value of dietary fat versus 2S - P","volume":"14","author":"Keys","year":"1965","journal-title":"Metabolism"},{"issue":"2","key":"2021120903015272500_B26","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1542\/peds.107.2.256","article-title":"Long-term safety and efficacy of a cholesterol-lowering diet in children with elevated low-density lipoprotein cholesterol: seven-year results of the Dietary Intervention Study in Children (DISC)","volume":"107","author":"Obarzanek","year":"2001","journal-title":"Pediatrics"},{"issue":"9","key":"2021120903015272500_B27","doi-asserted-by":"crossref","first-page":"2075","DOI":"10.1093\/jn\/135.9.2075","article-title":"Mechanisms by which dietary fatty acids modulate plasma lipids","volume":"135","author":"Fernandez","year":"2005","journal-title":"J Nutr"},{"issue":"1","key":"2021120903015272500_B28","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1093\/oxfordjournals.aje.a009192","article-title":"Trends in serum lipid levels during 1980-1992 in children and young adults. The Cardiovascular Risk in Young Finns Study","volume":"146","author":"Porkka","year":"1997","journal-title":"Am J Epidemiol"},{"issue":"2","key":"2021120903015272500_B29","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1046\/j.1365-2796.2003.01276.x","article-title":"Apolipoprotein B and apolipoprotein A-I: risk indicators of coronary heart disease and targets for lipid-modifying therapy","volume":"255","author":"Walldius","year":"2004","journal-title":"J Intern Med"},{"issue":"4","key":"2021120903015272500_B30","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1111\/j.1463-1326.2007.00714.x","article-title":"The contribution of ApoB and ApoA1 measurements to cardiovascular risk assessment","volume":"10","author":"Andrikoula","year":"2008","journal-title":"Diabetes Obes Metab"},{"key":"2021120903015272500_B31","doi-asserted-by":"crossref","first-page":"D9","DOI":"10.1016\/S1520-765X(03)90032-0","article-title":"Apolipoproteins: the new prognostic indicator?","volume":"5","author":"Packard","year":"2003","journal-title":"Eur Heart J"},{"issue":"6","key":"2021120903015272500_B32","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1161\/01.CIR.0000083723.75065.D4","article-title":"Effect of 7-year infancy-onset dietary intervention on serum lipoproteins and lipoprotein subclasses in healthy children in the prospective, randomized Special Turku Coronary Risk Factor Intervention Project for Children (STRIP) study","volume":"108","author":"Kaitosaari","year":"2003","journal-title":"Circulation"}],"container-title":["Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/publications.aap.org\/pediatrics\/article-pdf\/129\/3\/e704\/1057438\/peds_2011-1503.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/publications.aap.org\/pediatrics\/article-pdf\/129\/3\/e704\/1057438\/peds_2011-1503.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,9]],"date-time":"2021-12-09T16:36:38Z","timestamp":1639067798000},"score":1,"resource":{"primary":{"URL":"https:\/\/publications.aap.org\/pediatrics\/article\/129\/3\/e704\/31687\/Effect-of-Repeated-Dietary-Counseling-on-Serum"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,3,1]]},"references-count":32,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2012,3,1]]},"published-print":{"date-parts":[[2012,3,1]]}},"URL":"https:\/\/doi.org\/10.1542\/peds.2011-1503","relation":{},"ISSN":["0031-4005","1098-4275"],"issn-type":[{"value":"0031-4005","type":"print"},{"value":"1098-4275","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,3,1]]}}}