{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T08:32:58Z","timestamp":1774686778815,"version":"3.50.1"},"reference-count":9,"publisher":"American Academy of Pediatrics (AAP)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,4,1]]},"abstract":"<jats:p>Vitamin D deficiency causes rickets, requiring vitamin D at doses greater than daily dietary intake. Several treatment regimens are found in the literature, with wide dosing ranges, inconsistent monitoring schedules, and lack of age-specific guidelines. We describe 3 children, ages 2 weeks to 2 and 9\/12 years, who recently presented to our institution with hypercalcemia and hypervitaminosis D (25-hydroxyvitamin D levels &amp;gt;75 ng\/mL), associated with treatment of documented or suspected vitamin D-deficient rickets. The doses of vitamin D used were within accepted guidelines and believed to be safe. The patients required between 6 weeks and 6 months to correct the elevated serum calcium, with time to resolution of hypercalcemia related to age and peak serum calcium, but not to peak 25-hydroxyvitamin D level. With recent widespread use of vitamin D in larger dosages in the general population, we provide evidence that care must be taken when using pharmacologic dosing in small children. With limited dosing guidelines available on a per weight basis, the administration of dosages to infants that are often used in older children and adults has toxic potential, requiring a cautious approach in dose selection and careful follow-up. Dosage recommendations may need to be reassessed, in particular, where follow-up and monitoring may be compromised.<\/jats:p>","DOI":"10.1542\/peds.2011-1663","type":"journal-article","created":{"date-parts":[[2012,3,13]],"date-time":"2012-03-13T00:30:43Z","timestamp":1331598643000},"page":"e1060-e1063","source":"Crossref","is-referenced-by-count":37,"title":["Hypercalcemia in Children Receiving Pharmacologic Doses of Vitamin D"],"prefix":"10.1542","volume":"129","author":[{"given":"Michelle B.","family":"Vanstone","sequence":"first","affiliation":[{"name":"Department of Pediatrics (Endocrinology), Yale University School of Medicine, New Haven, Connecticut;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sharon E.","family":"Oberfield","sequence":"additional","affiliation":[{"name":"Division of Pediatric Endocrinology, Morgan Stanley Children's Hospital of New York, Columbia University Medical Center, New York, New York; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laurel","family":"Shader","sequence":"additional","affiliation":[{"name":"Fairhaven Community Health Center, New Haven, Connecticut"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laleh","family":"Ardeshirpour","sequence":"additional","affiliation":[{"name":"Department of Pediatrics (Endocrinology), Yale University School of Medicine, New Haven, Connecticut;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas O.","family":"Carpenter","sequence":"additional","affiliation":[{"name":"Department of Pediatrics (Endocrinology), Yale University School of Medicine, New Haven, Connecticut;"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"417","published-online":{"date-parts":[[2012,4,1]]},"reference":[{"issue":"3","key":"2021120903550310600_B1","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/j.ecl.2005.04.002","article-title":"Rickets and vitamin D deficiency in children and adolescents","volume":"34","author":"Pettifor","year":"2005","journal-title":"Endocrinol Metab Clin North Am"},{"issue":"2","key":"2021120903550310600_B2","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1542\/peds.2007-1894","article-title":"Vitamin D deficiency in children and its management: review of current knowledge and recommendations","volume":"122","author":"Misra","year":"2008","journal-title":"Pediatrics"},{"issue":"1","key":"2021120903550310600_B3","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1210\/jc.2010-2704","article-title":"The 2011 report on dietary reference intakes for calcium and vitamin D from the Institute of Medicine: what clinicians need to know","volume":"96","author":"Ross","year":"2011","journal-title":"J Clin Endocrinol Metab"},{"issue":"2","key":"2021120903550310600_B4","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1542\/peds.2006-0108","article-title":"Vitamin D deficiency in breastfed infants in Iowa","volume":"118","author":"Ziegler","year":"2006","journal-title":"Pediatrics"},{"key":"2021120903550310600_B5","first-page":"531","article-title":"Rickets and osteoporosis","volume-title":"Pediatric Endocrinology","author":"Plotkin","year":"2009","edition":"5th ed."},{"issue":"3","key":"2021120903550310600_B6","doi-asserted-by":"crossref","DOI":"10.1542\/peds.2004-2580","article-title":"Acute vitamin D intoxication in a child","volume":"116","author":"Barrueto","year":"2005","journal-title":"Pediatrics"},{"issue":"6","key":"2021120903550310600_B7","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1093\/tropej\/fmp020","article-title":"Hypercalcemia due to hypervitaminosis D: report of seven patients","volume":"55","author":"Joshi","year":"2009","journal-title":"J Trop Pediatr"},{"issue":"3","key":"2021120903550310600_B8","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1002\/jbmr.327","article-title":"Evidence-based policy on dietary calcium and vitamin D","volume":"26","author":"Reid","year":"2011","journal-title":"J Bone Miner Res"},{"key":"2021120903550310600_B9","volume-title":"2011 Dietary Reference Intakes for Calcium and Vitamin D","author":"Institute of Medicine","year":"2011"}],"container-title":["Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/publications.aap.org\/pediatrics\/article-pdf\/129\/4\/e1060\/1056497\/peds_2011-1663.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/publications.aap.org\/pediatrics\/article-pdf\/129\/4\/e1060\/1056497\/peds_2011-1663.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,9]],"date-time":"2021-12-09T19:56:44Z","timestamp":1639079804000},"score":1,"resource":{"primary":{"URL":"https:\/\/publications.aap.org\/pediatrics\/article\/129\/4\/e1060\/32373\/Hypercalcemia-in-Children-Receiving-Pharmacologic"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,4,1]]},"references-count":9,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2012,4,1]]},"published-print":{"date-parts":[[2012,4,1]]}},"URL":"https:\/\/doi.org\/10.1542\/peds.2011-1663","relation":{},"ISSN":["0031-4005","1098-4275"],"issn-type":[{"value":"0031-4005","type":"print"},{"value":"1098-4275","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,4,1]]}}}