{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T13:46:50Z","timestamp":1785246410777,"version":"3.55.0"},"reference-count":32,"publisher":"American Academy of Pediatrics (AAP)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,2,1]]},"abstract":"<jats:sec><jats:title>OBJECTIVE:<\/jats:title><jats:p>To evaluate the effectiveness of intravenous immunoglobulin (IVIG) treatment of Kawasaki disease \u226510 days after illness onset.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS:<\/jats:title><jats:p>We selected patients initially treated with IVIG on days 11 to 20 in the database of the 20th nationwide survey in Japan. We then selected pair-matched control subjects of the same gender and age, who were initially treated with IVIG on days 4 to 8 with the same dose at the same institutions. We compared the proportions of additional treatments and coronary artery lesions (CALs) between the groups. We also compared fractional changes in various laboratory data before and after IVIG. Fractional change was defined as follows: (Y \u2212 X)\/X, in which X represents the data before treatment and Y the data after treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS:<\/jats:title><jats:p>One hundred fifty patients (75 pairs) were studied. The proportion of patients who received additional treatments among those given initial IVIG after days 10 was slightly lower than those treated earlier (12% vs 16%). The fractional changes in the white blood cell count, % neutrophils, and C-reactive protein were similar. Among all patients, the proportions of CALs during the convalescent phase were significantly higher in the late than in the early group (27% vs 1%). Among patients who had not developed CALs before initial treatment, the proportions with CALs during the acute phase were similar (8% vs 8%).<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS:<\/jats:title><jats:p>IVIG treatment \u226510 days after illness onset achieves resolution of inflammation but was found to be insufficient for preventing CALs.<\/jats:p><\/jats:sec>","DOI":"10.1542\/peds.2011-1704","type":"journal-article","created":{"date-parts":[[2012,1,17]],"date-time":"2012-01-17T01:30:18Z","timestamp":1326763818000},"page":"e291-e297","source":"Crossref","is-referenced-by-count":53,"title":["Late Intravenous Immunoglobulin Treatment in Patients With Kawasaki Disease"],"prefix":"10.1542","volume":"129","author":[{"given":"Hiromi","family":"Muta","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Iizuka City Hospital, Iizuka, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiro","family":"Ishii","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Kitasato University, Sagamihara, Japan; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayumi","family":"Yashiro","sequence":"additional","affiliation":[{"name":"Department of Public Health, Jichi Medical University, Shimotsuke, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ritei","family":"Uehara","sequence":"additional","affiliation":[{"name":"Department of Public Health, Jichi Medical University, Shimotsuke, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yosikazu","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Department of Public Health, Jichi Medical University, Shimotsuke, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"417","published-online":{"date-parts":[[2012,2,1]]},"reference":[{"issue":"23","key":"2021120903095302400_B1","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1056\/NEJM199106063242305","article-title":"A single intravenous infusion of gamma globulin as compared with four infusions in the treatment of acute Kawasaki syndrome","volume":"324","author":"Newburger","year":"1991","journal-title":"N Engl J Med"},{"issue":"6","key":"2021120903095302400_B2","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1542\/peds.96.6.1057","article-title":"The prevention of coronary artery aneurysm in Kawasaki disease: a meta-analysis on the efficacy of aspirin and immunoglobulin treatment","volume":"96","author":"Durongpisitkul","year":"1995","journal-title":"Pediatrics"},{"issue":"6","key":"2021120903095302400_B3","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1016\/S0022-3476(97)70038-6","article-title":"Prevalence of coronary artery abnormalities in Kawasaki disease is highly dependent on gamma globulin dose but independent of salicylate dose","volume":"131","author":"Terai","year":"1997","journal-title":"J Pediatr"},{"issue":"1","key":"2021120903095302400_B4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1046\/j.1442-200X.1999.t01-1-01014.x","article-title":"Selective high dose gamma-globulin treatment in Kawasaki disease: assessment of clinical aspects and cost effectiveness","volume":"41","author":"Sato","year":"1999","journal-title":"Pediatr Int"},{"issue":"4","key":"2021120903095302400_B5","first-page":"CD004000","article-title":"Intravenous immunoglobulin for the treatment of Kawasaki disease in children","author":"Oates-Whitehead","year":"2003","journal-title":"Cochrane Database Syst Rev"},{"issue":"17","key":"2021120903095302400_B6","doi-asserted-by":"crossref","first-page":"2747","DOI":"10.1161\/01.CIR.0000145143.19711.78","article-title":"Diagnosis, treatment, and long-term management of Kawasaki disease: a statement for health professionals from the Committee on Rheumatic Fever, Endocarditis and Kawasaki disease, Council on Cardiovascular Disease in the Young, American Heart Association","volume":"110","author":"Newburger","year":"2004","journal-title":"Circulation"},{"issue":"7","key":"2021120903095302400_B7","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1001\/archpedi.160.7.686","article-title":"Prevalence of coronary artery lesions on the initial echocardiogram in Kawasaki syndrome","volume":"160","author":"Baer","year":"2006","journal-title":"Arch Pediatr Adolesc Med"},{"issue":"9","key":"2021120903095302400_B8","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1007\/s004310051181","article-title":"Factors related to cardiac sequelae of Kawasaki disease","volume":"158","author":"Zhang","year":"1999","journal-title":"Eur J Pediatr"},{"issue":"4","key":"2021120903095302400_B9","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1007\/s002469900458","article-title":"Effects of gamma-globulin on the cardiac sequelae of Kawasaki disease","volume":"20","author":"Yanagawa","year":"1999","journal-title":"Pediatr Cardiol"},{"issue":"8","key":"2021120903095302400_B10","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1016\/0002-9149(91)90658-8","article-title":"Late intravenous gamma globulin treatment in infants and children with Kawasaki disease and coronary artery abnormalities","volume":"68","author":"Marasini","year":"1991","journal-title":"Am J Cardiol"},{"issue":"4","key":"2021120903095302400_B11","doi-asserted-by":"crossref","first-page":"302","DOI":"10.2188\/jea.JE20090180","article-title":"Epidemiologic features of Kawasaki disease in Japan: results of the 2007-2008 nationwide survey","volume":"20","author":"Nakamura","year":"2010","journal-title":"J Epidemiol"},{"issue":"2","key":"2021120903095302400_B12","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1111\/j.1442-200x.2005.02033.x","article-title":"Revision of diagnostic guidelines for Kawasaki disease (the 5th revised edition)","volume":"47","author":"Ayusawa","year":"2005","journal-title":"Pediatr Int"},{"key":"2021120903095302400_B13"},{"issue":"2","key":"2021120903095302400_B14","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1067\/mpd.2000.107890","article-title":"Predictors of coronary artery lesions after intravenous \u03b3-globulin treatment in Kawasaki disease","volume":"137","author":"Mori","year":"2000","journal-title":"J Pediatr"},{"issue":"4","key":"2021120903095302400_B15","doi-asserted-by":"crossref","DOI":"10.1542\/peds.2004-1824","article-title":"Delayed diagnosis of Kawasaki syndrome: an analysis of the problem","volume":"115","author":"Anderson","year":"2005","journal-title":"Pediatrics"},{"issue":"6","key":"2021120903095302400_B16","doi-asserted-by":"crossref","DOI":"10.1542\/peds.2007-0815","article-title":"Delayed diagnosis of Kawasaki disease: what are the risk factors?","volume":"120","author":"Minich","year":"2007","journal-title":"Pediatrics"},{"issue":"3","key":"2021120903095302400_B17","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1097\/01.inf.0000256783.57041.66","article-title":"Delayed diagnosis by physicians contributes to the development of coronary artery aneurysms in children with Kawasaki syndrome","volume":"26","author":"Wilder","year":"2007","journal-title":"Pediatr Infect Dis J"},{"issue":"9","key":"2021120903095302400_B18","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/S1726-4901(08)70023-6","article-title":"The clinical manifestations and risk factors of adelayed diagnosis of Kawasaki disease","volume":"70","author":"Juan","year":"2007","journal-title":"J Chin Med Assoc"},{"issue":"26","key":"2021120903095302400_B19","first-page":"1841","article-title":"Comparison of efficacy among early, conventional and late intravenous gamma globulin treatment of Kawasaki disease","volume":"89","author":"Du","year":"2009","journal-title":"Zhonghua Yi Xue Za Zhi"},{"issue":"2","key":"2021120903095302400_B20","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1179\/1465328111Y.0000000005","article-title":"Delayed diagnosis of Kawasaki disease: risk factors and outcome of treatment","volume":"31","author":"Sittiwangkul","year":"2011","journal-title":"Ann Trop Paediatr"},{"issue":"5","key":"2021120903095302400_B21","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/S0022-3476(86)80689-8","article-title":"Clinical spectrum of Kawasaki disease in infants younger than 6 months of age","volume":"109","author":"Burns","year":"1986","journal-title":"J Pediatr"},{"issue":"3","key":"2021120903095302400_B22","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1097\/01.inf.0000202067.50975.90","article-title":"Characteristics of Kawasaki disease in infants younger than six months of age","volume":"25","author":"Chang","year":"2006","journal-title":"Pediatr Infect Dis J"},{"issue":"4","key":"2021120903095302400_B23","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1016\/S0022-3476(95)70344-6","article-title":"Kawasaki disease in infants less than one year of age","volume":"126","author":"Rosenfeld","year":"1995","journal-title":"J Pediatr"},{"issue":"4","key":"2021120903095302400_B24","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1111\/j.1442-200X.2007.02396.x","article-title":"Prevalence of coronary artery abnormality in incomplete Kawasaki disease","volume":"49","author":"Sonobe","year":"2007","journal-title":"Pediatr Int"},{"issue":"2","key":"2021120903095302400_B25","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1097\/INF.0b013e31815922b5","article-title":"Analysis of potential risk factors associated with nonresponse to initial intravenous immunoglobulin treatment among Kawasaki disease patients in Japan","volume":"27","author":"Uehara","year":"2008","journal-title":"Pediatr Infect Dis J"},{"issue":"2","key":"2021120903095302400_B26","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.jpeds.2006.03.050","article-title":"Prediction of resistance to intravenous immunoglobulin treatment in patients with Kawasaki disease","volume":"149","author":"Egami","year":"2006","journal-title":"J Pediatr"},{"issue":"22","key":"2021120903095302400_B27","doi-asserted-by":"crossref","first-page":"2606","DOI":"10.1161\/CIRCULATIONAHA.105.592865","article-title":"Prediction of intravenous immunoglobulin unresponsiveness in patients with Kawasaki disease","volume":"113","author":"Kobayashi","year":"2006","journal-title":"Circulation"},{"issue":"2","key":"2021120903095302400_B28","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1007\/s00431-006-0223-z","article-title":"Prediction of non-responsiveness to standard high-dose gamma-globulin therapy in patients with acute Kawasaki disease before starting initial treatment","volume":"166","author":"Sano","year":"2007","journal-title":"Eur J Pediatr"},{"issue":"5","key":"2021120903095302400_B29","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1016\/j.jpeds.2009.04.058","article-title":"Increased detection rate of Kawasaki disease using new diagnostic algorithm, including early use of echocardiography","volume":"155","author":"Heuclin","year":"2009","journal-title":"J Pediatr"},{"issue":"2","key":"2021120903095302400_B30","doi-asserted-by":"crossref","DOI":"10.1542\/peds.2009-0606","article-title":"Performance of 2004 American Heart Association recommendations for treatment of Kawasaki disease","volume":"125","author":"Yellen","year":"2010","journal-title":"Pediatrics"},{"issue":"3","key":"2021120903095302400_B31","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1016\/j.jpeds.2011.02.029","article-title":"Perivascular brightness of coronary arteries in Kawasaki disease","volume":"159","author":"Yu","year":"2011","journal-title":"J Pediatr"},{"issue":"2","key":"2021120903095302400_B32","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/S0022-3476(98)70229-X","article-title":"Coronary artery dimensions may be misclassified as normal in Kawasaki disease","volume":"133","author":"de Zorzi","year":"1998","journal-title":"J Pediatr"}],"container-title":["Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/publications.aap.org\/pediatrics\/article-pdf\/129\/2\/e291\/1056856\/peds_2011-1704.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/publications.aap.org\/pediatrics\/article-pdf\/129\/2\/e291\/1056856\/peds_2011-1704.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,26]],"date-time":"2021-12-26T05:58:20Z","timestamp":1640498300000},"score":1,"resource":{"primary":{"URL":"https:\/\/publications.aap.org\/pediatrics\/article\/129\/2\/e291\/32514\/Late-Intravenous-Immunoglobulin-Treatment-in"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,2,1]]},"references-count":32,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2012,2,1]]},"published-print":{"date-parts":[[2012,2,1]]}},"URL":"https:\/\/doi.org\/10.1542\/peds.2011-1704","relation":{},"ISSN":["0031-4005","1098-4275"],"issn-type":[{"value":"0031-4005","type":"print"},{"value":"1098-4275","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,2,1]]}}}