{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T23:40:56Z","timestamp":1791934856744,"version":"4.3.4"},"reference-count":19,"publisher":"American Academy of Pediatrics (AAP)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,5,1]]},"abstract":"\n OBJECTIVE:<\/jats:title>\n Nonadherence to antiretroviral therapy among children\/youth with HIV often is associated with disease progression. This study examined the agreement between child and caregiver perceptions of barriers to adherence and factors associated with these barriers.<\/jats:p>\n <\/jats:sec>\n \n METHODS:<\/jats:title>\n Children\/youth with perinatally acquired HIV and their parents\/caregivers (n = 120 dyads) completed a questionnaire about 19 potential barriers to adherence to the child\u2019s antiretroviral therapy regimen. Agreement between the 2 reports was measured via the kappa statistic. Factors associated with the barriers were assessed by using multiple logistic regression.<\/jats:p>\n <\/jats:sec>\n \n RESULTS:<\/jats:title>\n Of the 120 children, 55% were African American, 54% were boys, and the average age was 12.8 years. The most frequently reported barrier by either the caregiver or youth was \u201cforgot.\u201d There were varying degrees of agreement between child and caregiver on the following barriers: \u201cforgot,\u201d \u201ctaste,\u201d \u201cchild was away from home,\u201d \u201cchild refused,\u201d and \u201cchild felt good.\u201d Children who knew their HIV status were more likely to report logistical barriers, such as scheduling issues. Children with a biological parent as their caregiver were more likely to report regimen or fear of disclosure as a barrier.<\/jats:p>\n <\/jats:sec>\n \n CONCLUSIONS:<\/jats:title>\n Lack of agreement was observed for more than half of the studied barriers, indicating discrepancies between children\u2019s and caregivers\u2019 perceptions of factors that influence medication-taking. The findings suggest a need for interventions that involve both child and caregiver in the tasks of remembering when to administer the child\u2019s medications, sustaining adherence, and appropriately transitioning medication responsibility to the youth.<\/jats:p>\n <\/jats:sec>","DOI":"10.1542\/peds.2011-1740","type":"journal-article","created":{"date-parts":[[2012,4,17]],"date-time":"2012-04-17T00:32:20Z","timestamp":1334622740000},"page":"e1244-e1251","source":"Crossref","is-referenced-by-count":93,"title":["Barriers to Medication Adherence in HIV-Infected Children and Youth Based on Self- and Caregiver Report"],"prefix":"10.1542","volume":"129","author":[{"given":"Ashley L.","family":"Buchanan","sequence":"first","affiliation":[{"name":"Center for Biostatistics in AIDS Research, Harvard School of Public Health, Boston, Massachusetts;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grace","family":"Montepiedra","sequence":"additional","affiliation":[{"name":"Center for Biostatistics in AIDS Research, Harvard School of Public Health, Boston, Massachusetts;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia A.","family":"Sirois","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Tulane University School of Medicine, New Orleans, Louisiana;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Betsy","family":"Kammerer","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Children's Hospital Boston, Boston, Massachusetts;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia A.","family":"Garvie","sequence":"additional","affiliation":[{"name":"Department of Behavioral Medicine, St. Jude Children\u2019s Research Hospital, Memphis, Tennessee;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah S.","family":"Storm","sequence":"additional","affiliation":[{"name":"Francois-Xavier Bagnoud Center, School of Nursing, University of Medicine and Dentistry of New Jersey, Newark, New Jersey; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharon L.","family":"Nichols","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, University of California, San Diego, La Jolla, California"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"417","published-online":{"date-parts":[[2012,5,1]]},"reference":[{"issue":"4","key":"2022051611020575800_B1","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1086\/526524","article-title":"Long-term effectiveness of highly active antiretroviral therapy on the survival of children and adolescents with HIV infection: a 10-year follow-up study.","volume":"46","author":"Patel","year":"2008","journal-title":"Clin Infect Dis"},{"issue":"12","key":"2022051611020575800_B2","doi-asserted-by":"crossref","first-page":"e8275","DOI":"10.1371\/journal.pone.0008275","article-title":"Impact of previous virological treatment failures and adherence on 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