{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T21:28:30Z","timestamp":1789421310299,"version":"build-2803163510"},"reference-count":9,"publisher":"American Academy of Pediatrics (AAP)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,12,1]]},"abstract":"<jats:p>Infants in NICUs undergo a variety of painful procedures. The management of pain has become an integral part of newborn infant care with the use of both systemic and topical agents to provide analgesia and anesthesia for procedural pain. Tetracaine and prilocaine-lidocaine are the 2 topical anesthetics most frequently used. Tetracaine belongs to an ester group of local anesthetics available as a topical 4% gel (Ametop, Smith and Nephew, Canada). The major side effects reported when using topical anesthetics are cutaneous reactions. There are no definite reports of systemic toxicity in the published literature. We present a recent case of an extremely low birth weight premature infant who developed a clinically significant arrhythmia after topical tetracaine was applied before the insertion of a peripherally inserted central catheter. The infant had no other identifiable cause for the resulting bradycardia that occurred only after Ametop was applied. The cardiac symptoms resolved with treatment. This case highlights a significant potential adverse event when using topical tetracaine.<\/jats:p>","DOI":"10.1542\/peds.2011-1743","type":"journal-article","created":{"date-parts":[[2012,11,6]],"date-time":"2012-11-06T04:18:14Z","timestamp":1352175494000},"page":"e1704-e1707","source":"Crossref","is-referenced-by-count":11,"title":["Arrhythmia Associated With Tetracaine in an Extremely Low Birth Weight Premature Infant"],"prefix":"10.1542","volume":"130","author":[{"given":"Halima","family":"Maulidi","sequence":"first","affiliation":[{"name":"Divisions of Neonatology and Cardiology, Department of Paediatrics, Hospital for Sick Children and University of Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carol","family":"McNair","sequence":"additional","affiliation":[{"name":"Divisions of Neonatology and Cardiology, Department of Paediatrics, Hospital for Sick Children and University of Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil","family":"Seller","sequence":"additional","affiliation":[{"name":"Divisions of Neonatology and Cardiology, Department of Paediatrics, Hospital for Sick Children and University of Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel","family":"Kirsh","sequence":"additional","affiliation":[{"name":"Divisions of Neonatology and Cardiology, Department of Paediatrics, Hospital for Sick Children and University of Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy J.","family":"Bradley","sequence":"additional","affiliation":[{"name":"Divisions of Neonatology and Cardiology, Department of Paediatrics, Hospital for Sick Children and University of Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven C.","family":"Greenway","sequence":"additional","affiliation":[{"name":"Divisions of Neonatology and Cardiology, Department of Paediatrics, Hospital for Sick Children and University of Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris","family":"Tomlinson","sequence":"additional","affiliation":[{"name":"Divisions of Neonatology and Cardiology, Department of Paediatrics, Hospital for Sick Children and University of Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"417","published-online":{"date-parts":[[2012,12,1]]},"reference":[{"issue":"1","key":"2021120823545994300_B1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000013953","article-title":"Clinical importance of pain and stress in preterm neonates.","volume":"73","author":"Anand","year":"1998","journal-title":"Biol Neonate"},{"issue":"4","key":"2021120823545994300_B2","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1097\/00004703-199908000-00008","article-title":"Long-term effects of pain in 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