{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T03:37:12Z","timestamp":1782963432516,"version":"3.54.5"},"reference-count":31,"publisher":"American Academy of Pediatrics (AAP)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,5,1]]},"abstract":"<jats:p>Sweet syndrome is an inflammatory disease characterized by fever and painful erythematous plaques with a dermal neutrophilic infiltrate. It is most common in adults, where it is often parainflammatory or paraneoplastic, but is rare in children. We describe 3 cases of neonatal Sweet syndrome, including 1 patient who had myelodysplastic syndrome and immunodeficiency, the first report of a premalignancy underlying infantile Sweet syndrome. We reviewed the literature on patients presenting with neutrophilic dermatosis in the first 6 months of life. Of 20 cases, 6 had a probable viral etiology, 4 primary immunodeficiencies, 3 neonatal lupus syndrome, 1 gastrointestinal involvement, 1 HIV, and 5 probable genetic cases. Three of these had chronic atypical neutrophilic dermatosis with lipodystrophy and elevated temperature syndrome, caused by mutations in the PSMB8 gene. Most children who presented within the first 6 weeks of life had either a serious underlying condition, such as primary immunodeficiency, or a genetic Sweet syndrome, with 2 fatalities among this latter group. The outcome of postinfective cases was good. Extracutaneous involvement was unusual, whereas postinflammatory scarring and cutis laxa occurred in a minority of patients. In conclusion, Sweet syndrome in the neonatal period often heralds a serious underlying disorder and requires thorough investigation.<\/jats:p>","DOI":"10.1542\/peds.2011-1854","type":"journal-article","created":{"date-parts":[[2012,4,17]],"date-time":"2012-04-17T00:32:20Z","timestamp":1334622740000},"page":"e1353-e1359","source":"Crossref","is-referenced-by-count":30,"title":["Neonatal Sweet Syndrome: A Potential Marker of Serious Systemic Illness"],"prefix":"10.1542","volume":"129","author":[{"given":"Paul E. A.","family":"Gray","sequence":"first","affiliation":[{"name":"Departments of Immunology"},{"name":"School of Women\u2019s and Children\u2019s Health, University of New South Wales, Kensington, New South Wales, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanessa","family":"Bock","sequence":"additional","affiliation":[{"name":"Dermatology, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David S.","family":"Ziegler","sequence":"additional","affiliation":[{"name":"School of Women\u2019s and Children\u2019s Health, University of New South Wales, Kensington, New South Wales, Australia"},{"name":"Centre for Children's Cancer and Blood Disorders, Sydney Children's Hospital, Randwick, New South Wales, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Orli","family":"Wargon","sequence":"additional","affiliation":[{"name":"School of Women\u2019s and Children\u2019s Health, University of New South Wales, Kensington, New South Wales, Australia"},{"name":"Centre for Children's Cancer and Blood Disorders, Sydney Children's Hospital, Randwick, New South Wales, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"417","published-online":{"date-parts":[[2012,5,1]]},"reference":[{"issue":"8","key":"2022051611103964800_B1","first-page":"419","article-title":"Sweet\u2019s syndrome and intestinal inflammatory disease. A case report and review of the literature [in Spanish].","volume":"19","author":"Anglada Pintado","year":"2002","journal-title":"Med Interna"},{"issue":"2","key":"2022051611103964800_B2","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1111\/j.1365-2141.1994.tb04757.x","article-title":"Sweet\u2019s syndrome in myeloid malignancy: a report of two cases.","volume":"86","author":"van Kamp","year":"1994","journal-title":"Br J Haematol"},{"issue":"3","key":"2022051611103964800_B3","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1111\/j.1365-2133.2006.07677.x","article-title":"Sweet\u2019s syndrome: a spectrum of unusual clinical presentations and associations.","volume":"156","author":"Neoh","year":"2007","journal-title":"Br J Dermatol"},{"key":"2022051611103964800_B4","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/1750-1172-2-34","article-title":"Sweet\u2019s syndrome\u2014a comprehensive review of an acute febrile neutrophilic dermatosis.","volume":"2","author":"Cohen","year":"2007","journal-title":"Orphanet J Rare Dis"},{"issue":"2","key":"2022051611103964800_B5","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1111\/j.1365-2230.2008.02814.x","article-title":"Sweet\u2019s syndrome in association with common variable immunodeficiency.","volume":"34","author":"O\u2019Regan","year":"2009","journal-title":"Clin Exp Dermatol"},{"issue":"5 pt 1","key":"2022051611103964800_B6","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1542\/peds.104.5.1142","article-title":"Sweet\u2019s syndrome as an initial manifestation of pediatric human immunodeficiency virus infection.","volume":"104","author":"Brady","year":"1999","journal-title":"Pediatrics"},{"issue":"5 pt 2","key":"2022051611103964800_B7","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1016\/S0190-9622(96)90080-8","article-title":"Trimethoprim-sulfamethoxazole-associated acute febrile neutrophilic dermatosis: case report and review of drug-induced Sweet\u2019s syndrome.","volume":"34","author":"Walker","year":"1996","journal-title":"J Am Acad Dermatol"},{"issue":"3","key":"2022051611103964800_B8","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1002\/ajh.20112","article-title":"Sweet\u2019s syndrome associated with sargramostim (granulocyte-macrophage colony stimulating factor) treatment.","volume":"76","author":"Kumar","year":"2004","journal-title":"Am J Hematol"},{"issue":"12","key":"2022051611103964800_B9","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1111\/j.1365-4632.2004.02000.x","article-title":"Sweet\u2019s syndrome associated with Staphylococcus aureus.","volume":"43","author":"Abramovits","year":"2004","journal-title":"Int J Dermatol"},{"issue":"1","key":"2022051611103964800_B10","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1046\/j.1365-2133.1998.02324.x","article-title":"Sweet\u2019s syndrome associated with non-tuberculous mycobacterial infection: a report of five cases.","volume":"139","author":"Choonhakarn","year":"1998","journal-title":"Br J Dermatol"},{"issue":"5","key":"2022051611103964800_B11","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1016\/j.jaad.2003.05.003","article-title":"Sweet\u2019s syndrome in a patient with enterococcal subacute bacterial endocarditis.","volume":"50","author":"Gould","year":"2004","journal-title":"J Am Acad Dermatol"},{"issue":"3","key":"2022051611103964800_B12","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1111\/j.1525-1470.2009.00919.x","article-title":"Acquired cutis laxa in childhood Sweet\u2019s syndrome.","volume":"26","author":"Timmer-DE Mik","year":"2009","journal-title":"Pediatr Dermatol"},{"issue":"4","key":"2022051611103964800_B13","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1111\/j.1525-1470.2009.00952.x","article-title":"Pediatric sweet syndrome: case report and literature review.","volume":"26","author":"Halpern","year":"2009","journal-title":"Pediatr Dermatol"},{"issue":"1","key":"2022051611103964800_B14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00431-008-0812-0","article-title":"Acute febrile neutrophilic dermatosis (Sweet\u2019s syndrome) in childhood and adolescence: two new patients and review of the literature on associated diseases.","volume":"168","author":"Hospach","year":"2009","journal-title":"Eur J Pediatr"},{"issue":"10","key":"2022051611103964800_B15","first-page":"865","article-title":"The anal lesion as the sole presenting symptom of intestinal Crohn\u2019s disease.","volume":"12","author":"Baker","year":"1971","journal-title":"Gut"},{"issue":"2","key":"2022051611103964800_B16","doi-asserted-by":"crossref","first-page":"179","DOI":"10.3324\/haematol.2009.016865","article-title":"Molecular basis of juvenile myelomonocytic leukemia.","volume":"95","author":"de 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