{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T18:36:25Z","timestamp":1790361385729,"version":"4.1.0"},"reference-count":12,"publisher":"American Academy of Pediatrics (AAP)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,2,1]]},"abstract":"<jats:p>An intravenous formulation of acetaminophen was introduced to the United States in 2011. Experience from Europe indicates that serious dosing errors are likely to occur. Most events have involved a 10-fold dosing error in small children caused by calculating the dosage in milligrams, but then administering the solution in milliliters. The solution is 10 mg\/mL; therefore, a 10-fold overdose occurs. Evaluation of overdose with the intravenous formulation is similar to oral overdose. A serum acetaminophen concentration should be drawn 4 hours after the infusion was started or as soon thereafter as possible. If the serum acetaminophen concentration plots above the treatment line on the Rumack-Matthew nomogram, treatment with acetylcysteine should be initiated. Health care providers are encouraged to contact their regional poison center (1-800-222-1222) so that dosing errors will be reported, and the experience with this new product can be accumulated.<\/jats:p>","DOI":"10.1542\/peds.2011-2345","type":"journal-article","created":{"date-parts":[[2012,1,24]],"date-time":"2012-01-24T05:34:55Z","timestamp":1327383295000},"page":"349-353","source":"Crossref","is-referenced-by-count":62,"title":["Intravenous Acetaminophen in the United States: Iatrogenic Dosing Errors"],"prefix":"10.1542","volume":"129","author":[{"given":"Richard C.","family":"Dart","sequence":"first","affiliation":[{"name":"Rocky Mountain Poison and Drug Center, Denver Health, Denver, Colorado;"},{"name":"Departments of Emergency Medicine and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barry H.","family":"Rumack","sequence":"additional","affiliation":[{"name":"Rocky Mountain Poison and Drug Center, Denver Health, Denver, Colorado;"},{"name":"Pediatrics, University of Colorado School of Medicine, Denver, Colorado"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"417","published-online":{"date-parts":[[2012,2,1]]},"reference":[{"key":"2021120903153139700_B1"},{"issue":"12","key":"2021120903153139700_B2","first-page":"1","volume":"3","author":"Medicines and Healthcare products Regulatory Agency","year":"2010","journal-title":"Drug Safety Update"},{"issue":"3","key":"2021120903153139700_B3","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1136\/adc.2010.192005","article-title":"Intravenous paracetamol overdose: two case reports and a change to national treatment guidelines","volume":"96","author":"Beringer","year":"2011;","journal-title":"Arch Dis Child."},{"issue":"1","key":"2021120903153139700_B4","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1111\/j.1460-9592.2009.03210.x","article-title":"Intravenous paracetamol overdose in a preterm infant during anesthesia","volume":"20","author":"Nevin","year":"2010","journal-title":"Paediatr Anaesth"},{"issue":"2","key":"2021120903153139700_B5","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1081\/CLT-120030939","article-title":"Acetaminophen: the 150 mg\/kg myth","volume":"42","author":"Tenenbein","year":"2004","journal-title":"J Toxicol Clin Toxicol"},{"issue":"1","key":"2021120903153139700_B6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/15563650500394571","article-title":"Acetaminophen poisoning: an evidence-based consensus guideline for out-of-hospital management","volume":"44","author":"Dart","year":"2006","journal-title":"Clin Toxicol (Phila)"},{"issue":"8","key":"2021120903153139700_B7","doi-asserted-by":"crossref","first-page":"787","DOI":"10.3109\/15563650.2010.523828","article-title":"When do the aminotransferases rise after acute acetaminophen overdose?","volume":"48","author":"Green","year":"2010","journal-title":"Clin Toxicol (Phila)"},{"issue":"10","key":"2021120903153139700_B8","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1007\/BF01959078","article-title":"Liver dysfunction and acute cardiocirculatory failure in children","volume":"151","author":"Jacquemin","year":"1992","journal-title":"Eur J Pediatr"},{"key":"2021120903153139700_B9"},{"key":"2021120903153139700_B10"},{"issue":"2","key":"2021120903153139700_B11","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1111\/j.1432-1033.1996.0476z.x","article-title":"Developmental expression of CYP2E1 in the human liver. 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