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These cases demonstrate that analgesia with codeine or other opioids that use the CYP2D6 pathway after adenotonsillectomy may not be safe in young children with obstructive sleep apnea syndrome.<\/jats:p>","DOI":"10.1542\/peds.2011-2538","type":"journal-article","created":{"date-parts":[[2012,4,9]],"date-time":"2012-04-09T20:14:41Z","timestamp":1334002481000},"page":"e1343-e1347","source":"Crossref","is-referenced-by-count":332,"title":["More Codeine Fatalities After Tonsillectomy in North American Children"],"prefix":"10.1542","volume":"129","author":[{"given":"Lauren E.","family":"Kelly","sequence":"first","affiliation":[{"name":"Schulich School of Medicine, and"},{"name":"Department of Clinical Pharmacology, London Health Sciences Centre, London, Canada;"},{"name":"Ivey Chair in Molecular Toxicology, University of Western Ontario, London, Canada;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Rieder","sequence":"additional","affiliation":[{"name":"Schulich School of Medicine, and"},{"name":"Department of Clinical Pharmacology, London Health Sciences Centre, London, Canada;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"van den Anker","sequence":"additional","affiliation":[{"name":"Children\u2019s National Medical Center, Center for Clinical and Community Research, Washington, District of Columbia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Becky","family":"Malkin","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology, London Health Sciences Centre, London, Canada;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colin","family":"Ross","sequence":"additional","affiliation":[{"name":"Centre for Molecular Medicine and Therapeutics, University of British Columbia, Vancouver, Canada;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael N.","family":"Neely","sequence":"additional","affiliation":[{"name":"Communication Sciences Institute, University of South California, Los Angeles, California;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce","family":"Carleton","sequence":"additional","affiliation":[{"name":"Centre for Molecular Medicine and Therapeutics, University of British Columbia, Vancouver, Canada;"},{"name":"Child and Family Research Institute, Vancouver, Canada;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael R.","family":"Hayden","sequence":"additional","affiliation":[{"name":"Centre for Molecular Medicine and Therapeutics, University of British Columbia, Vancouver, Canada;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parvaz","family":"Madadi","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology, University of Toronto, Toronto, Canada; and"},{"name":"Division of Clinical Pharmacology and Toxicology, Hospital for Sick Children, Toronto, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gideon","family":"Koren","sequence":"additional","affiliation":[{"name":"Ivey Chair in Molecular Toxicology, University of Western Ontario, London, Canada;"},{"name":"Department of Clinical Pharmacology, University of Toronto, Toronto, Canada; and"},{"name":"Division of Clinical Pharmacology and Toxicology, Hospital for Sick Children, Toronto, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"417","published-online":{"date-parts":[[2012,5,1]]},"reference":[{"key":"2022051617075454300_B1","doi-asserted-by":"crossref","first-page":"c1918","DOI":"10.1136\/bmj.c1918","article-title":"Paediatric obstructive sleep apnoea.","volume":"340","author":"Powell","year":"2010","journal-title":"BMJ"},{"issue":"1","key":"2022051617075454300_B2","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1007\/s12098-009-0266-z","article-title":"Pediatric obstructive sleep apnea.","volume":"77","author":"Chhangani","year":"2010","journal-title":"Indian J Pediatr"},{"key":"2022051617075454300_B3","unstructured":"Statistics Canada. 2006 Census release topics: age and sex. 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