{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T19:09:23Z","timestamp":1787166563848,"version":"build-2736575974"},"reference-count":31,"publisher":"American Academy of Pediatrics (AAP)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,5,1]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND AND OBJECTIVE:<\/jats:title>\n                    <jats:p>Both high and low lymphocyte counts at birth have been associated with adverse outcomes. However, the validity of defining a lymphocyte count as \u201cabnormal\u201d depends on having an accurate reference range. We established a reference range for neonatal lymphocyte counts by using multihospital data and used this to assess previously reported relationships between abnormal counts and early onset sepsis (EOS), intraventricular hemorrhage (IVH), retinopathy of prematurity (ROP), periventricular leukomalacia, and birth asphyxia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>We first created a data set that excluded counts from neonates with diagnoses previously associated with abnormal lymphocyte counts. Then the complete data (counts excluded plus included in the reference range) were used to test associations between abnormal counts and EOS, IVH, ROP, periventricular leukomalacia, and outcomes after birth asphyxia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>Lymphocyte counts were retrieved from 40\u2009487 neonates, 10\u2009860 of which were excluded from the reference range. A count &amp;gt;95th percentile was associated with EOS (2.07; 95% confidence interval [CI]: 1.80\u20132.38) and IVH \u2265grade 3 (2.93; 95% CI: 1.83\u20134.71). A count &amp;lt;5th percentile was associated with EOS (odds ratio:1.24; 95% CI: 1.04\u20131.48), IVH \u2265grade 3 (3.23; 95% CI: 1.95\u20135.36), and ROP \u2265stage 3 (4.80: 95% CI: 2.38\u20139.66). Among 120 meeting criteria for birth asphyxia, those with a low count and a high nucleated red cell count had higher mortality (37% vs 11%, P = .001), more transfusions (P = .000), and more neurology referrals (P &amp;lt; .01).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>A reference range for lymphocytes can identify neonates with abnormal counts, which can be useful because these neonates are at higher risk for certain adverse outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1542\/peds.2011-2661","type":"journal-article","created":{"date-parts":[[2012,4,16]],"date-time":"2012-04-16T20:32:20Z","timestamp":1334608340000},"page":"e1165-e1172","source":"Crossref","is-referenced-by-count":42,"title":["Reference Ranges for Lymphocyte Counts of Neonates: Associations Between Abnormal Counts and Outcomes"],"prefix":"10.1542","volume":"129","author":[{"given":"Robert D.","family":"Christensen","sequence":"first","affiliation":[{"name":"Women and Newborn\u2019s Clinical Program, Intermountain Healthcare, Ogden, Utah;"},{"name":"McKay-Dee Hospital Center, Ogden, Utah;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vickie L.","family":"Baer","sequence":"additional","affiliation":[{"name":"Women and Newborn\u2019s Clinical Program, Intermountain Healthcare, Ogden, Utah;"},{"name":"McKay-Dee Hospital Center, Ogden, Utah;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip V.","family":"Gordon","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Department of Pediatrics, Tulane School of Medicine, New Orleans, Louisiana;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erick","family":"Henry","sequence":"additional","affiliation":[{"name":"Women and Newborn\u2019s Clinical Program, Intermountain Healthcare, Ogden, Utah;"},{"name":"Institute for Healthcare Delivery Research, Salt Lake City, Utah;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cody","family":"Whitaker","sequence":"additional","affiliation":[{"name":"Institute for Healthcare Delivery Research, Salt Lake City, Utah;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert L.","family":"Andres","sequence":"additional","affiliation":[{"name":"Women and Newborn\u2019s Clinical Program, Intermountain Healthcare, Ogden, Utah;"},{"name":"McKay-Dee Hospital Center, Ogden, Utah;"},{"name":"Division of Fetal\/Maternal Medicine, University of Utah School of Medicine, Salt Lake City, Utah; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sterling T.","family":"Bennett","sequence":"additional","affiliation":[{"name":"Department of Pathology, Intermountain Medical Center, Murray, Utah"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"417","published-online":{"date-parts":[[2012,5,1]]},"reference":[{"issue":"3","key":"2022051623091423400_B1","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1016\/S0022-3476(85)80681-8","article-title":"Neonatal blood cell count in health and disease. 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