{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T12:10:09Z","timestamp":1790770209198,"version":"4.1.0"},"reference-count":16,"publisher":"American Academy of Pediatrics (AAP)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,11,1]]},"abstract":"<jats:p>Extracts of the plant Serenoa repens are widely used in male adults for the treatment of benign prostatic hyperplasia. Recently, therapy with S repens has been proposed as a \"natural\" alternative to conventional treatments for male androgenetic alopecia as well as for other hair disorders. Telogen effluvium is a form of alopecia characterized by abnormality of hair cycling, resulting in excessive loss of telogen hair. We report the case of an 11-year-old girl presenting hot flashes that appeared after treatment of telogen effluvium with a food supplement containing S repens that lasted for \u223c2 months. When use of the product was discontinued, the hot flashes no longer occurred. Four months after the start of S repens intake and 45 days from the cessation of therapy, the girl experienced menarche at the age of 11 years. The Naranjo adverse drug reaction probability scale indicated a probable relationship (score of 6) between the appearance of hot flashes and the intake of S repens. A correlation between exposure to S repens and the onset of menarche is not certain, but it cannot be excluded. Medicinal products or food supplements containing S repens are generally well tolerated in male adults, but we believe that their use in pediatric patients should be better evaluated.<\/jats:p>","DOI":"10.1542\/peds.2011-2679","type":"journal-article","created":{"date-parts":[[2012,10,2]],"date-time":"2012-10-02T04:35:12Z","timestamp":1349152512000},"page":"e1374-e1376","source":"Crossref","is-referenced-by-count":9,"title":["Hot Flashes in a Young Girl: A Wake-up Call Concerning <i>Serenoa repens<\/i> Use in Children"],"prefix":"10.1542","volume":"130","author":[{"given":"Marco","family":"Miroddi","sequence":"first","affiliation":[{"name":"Department of Clinical and Experimental Medicine and Pharmacology, School of Medicine, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Carn\u00ec","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine and Pharmacology, School of Medicine, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Mannucci","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine and Pharmacology, School of Medicine, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariacarla","family":"Moleti","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine and Pharmacology, School of Medicine, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Navarra","sequence":"additional","affiliation":[{"name":"Pharmaco-Biological Department, Faculty of Pharmacy, University of Messina, Messina, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gioacchino","family":"Calapai","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine and Pharmacology, School of Medicine, and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"417","published-online":{"date-parts":[[2012,11,1]]},"reference":[{"issue":"5","key":"2021120903555576200_B1","doi-asserted-by":"crossref","first-page":"428","DOI":"10.2165\/00002018-200831050-00009","article-title":"European legislation on herbal medicines: a look into the future.","volume":"31","author":"Calapai","year":"2008","journal-title":"Drug Saf"},{"key":"2021120903555576200_B2","first-page":"CD001423","article-title":"Serenoa repens for benign prostatic hyperplasia.","volume":"15","author":"Tacklind","year":"2009","journal-title":"Cochrane Database Syst."},{"issue":"4","key":"2021120903555576200_B3","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1159\/000474863","article-title":"Evidence that Serenoa repens extract displays an antiestrogenic activity in prostatic tissue of benign prostatic hypertrophy patients.","volume":"21","author":"Di Silverio","year":"1992","journal-title":"Eur Urol"},{"issue":"4","key":"2021120903555576200_B4","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1046\/j.1440-0960.2002.00620.x","article-title":"Sensitization to saw palmetto and minoxidil in separate topical extemporaneous treatments for androgenetic alopecia.","volume":"43","author":"Sinclair","year":"2002","journal-title":"Australas J Dermatol"},{"issue":"1","key":"2021120903555576200_B5","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1542\/pir.12-1-25","article-title":"Alopecia in children: the most common causes.","volume":"12","author":"Atton","year":"1990","journal-title":"Pediatr Rev"},{"issue":"3","key":"2021120903555576200_B6","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1001\/archderm.1993.01680240096017","article-title":"Telogen effluvium. 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