{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,8]],"date-time":"2025-05-08T13:32:48Z","timestamp":1746711168826,"version":"3.40.5"},"reference-count":23,"publisher":"American Academy of Pediatrics (AAP)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,5,1]]},"abstract":"<jats:p>A previously healthy 9-year-old girl presented with a 10-day history of slowly progressive unsteadiness, slurred speech, and behavior change. On examination there was cerebellar ataxia and dysarthria, excessive blinking, subtle perioral myoclonus, and labile mood. The finding of oligoclonal bands in the cerebrospinal fluid prompted paraneoplastic serological evaluation and search for an occult neural crest tumor. Antineuronal nuclear autoantibody type 1 (anti-Hu) and voltage-gated potassium channel complex antibodies were detected in serum. Metaiodobenzylguanidine scan and computed tomography scan of the abdomen showed a localized abdominal mass in the region of the porta hepatis. A diagnosis of occult neuroblastoma was made. Resection of the stage 1 neuroblastoma and treatment with pulsed corticosteroids resulted in resolution of all symptoms and signs. Excessive blinking has rarely been described with neuroblastoma, and, when it is not an isolated finding, it may be a useful clue to this paraneoplastic syndrome. Although voltage-gated potassium channel complex autoimmunity has not been described previously in the setting of neuroblastoma, it is associated with a spectrum of paraneoplastic neurologic manifestations in adults, including peripheral nerve hyperexcitability disorders.<\/jats:p>","DOI":"10.1542\/peds.2011-2690","type":"journal-article","created":{"date-parts":[[2012,4,24]],"date-time":"2012-04-24T02:34:56Z","timestamp":1335234896000},"page":"e1348-e1352","source":"Crossref","is-referenced-by-count":3,"title":["Excessive Blinking and Ataxia in a Child With Occult Neuroblastoma and Voltage-Gated Potassium Channel Antibodies"],"prefix":"10.1542","volume":"129","author":[{"given":"Nicholas M.","family":"Allen","sequence":"first","affiliation":[{"name":"Department of Pediatric Neurology and Clinical Neurophysiology, Children's University Hospital, Dublin 1, Ireland;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"McKeon","sequence":"additional","affiliation":[{"name":"Department of Neurology and Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Declan J.","family":"O\u2019Rourke","sequence":"additional","affiliation":[{"name":"Department of Pediatric Neurology and Clinical Neurophysiology, Children's University Hospital, Dublin 1, Ireland;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne","family":"O\u2019Meara","sequence":"additional","affiliation":[{"name":"Department of Paediatric Oncology, Our Lady\u2019s Children\u2019s Hospital, Crumlin, Dublin, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary D.","family":"King","sequence":"additional","affiliation":[{"name":"Department of Pediatric Neurology and Clinical Neurophysiology, Children's University Hospital, Dublin 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