{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,8]],"date-time":"2025-05-08T13:29:08Z","timestamp":1746710948235,"version":"3.40.5"},"reference-count":11,"publisher":"American Academy of Pediatrics (AAP)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,9,1]]},"abstract":"<jats:p>Topical application of eye drops may cause mild or severe adverse ocular or systemic effects. Children, particularly infants, are more prone to systemic adverse effects of topical eye drops because of their lower body mass and blood volume, immature metabolism, and immaturity of excretory, nervous, and cardiovascular systems. Early recognition of signs and symptoms of systemic toxicity is very important. Most of the signs and symptoms can resolve spontaneously; however, in severe cases, physostigmine treatment may be required. Respiratory distress is a rare adverse effect of cyclopentolate. We report an infant who developed respiratory distress after ocular instillation of cyclopentolate and was successfully treated with physostigmine. The benefit of physostigmine use with close follow-up should be borne in mind in cases with a life-threatening cyclopentolate adverse effect.<\/jats:p>","DOI":"10.1542\/peds.2011-3038","type":"journal-article","created":{"date-parts":[[2012,8,21]],"date-time":"2012-08-21T00:34:57Z","timestamp":1345509297000},"page":"e703-e705","source":"Crossref","is-referenced-by-count":10,"title":["Use of Physostigmine for Cyclopentolate Overdose in an Infant"],"prefix":"10.1542","volume":"130","author":[{"given":"Oksan","family":"Derinoz","sequence":"first","affiliation":[{"name":"Departments of Pediatric Emergency Medicine, and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hamdi C.","family":"Emeksiz","sequence":"additional","affiliation":[{"name":"Pediatrics, Gazi University Faculty of Medicine, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"417","published-online":{"date-parts":[[2012,9,1]]},"reference":[{"issue":"4","key":"2021120900275503500_B1","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1046\/j.1440-1754.2003.00144.x","article-title":"Transient paralytic ileus following the use of cyclo-pentolate-phenylephrine eye drops during screening for retinopathy of prematurity.","volume":"39","author":"Lim","year":"2003","journal-title":"J Paediatr Child Health"},{"issue":"1","key":"2021120900275503500_B2","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1111\/j.1475-1313.1991.tb00189.x","article-title":"Possible allergic reactions to cyclopentolate hydrochloride: case reports with literature review of uses and adverse reactions.","volume":"11","author":"Jones","year":"1991","journal-title":"Ophthalmic Physiol Opt"},{"issue":"11","key":"2021120900275503500_B3","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1007\/s00228-010-0890-6","article-title":"The local vasoconstriction of infant\u2019s skin following instillation of mydriatic eye drops.","volume":"66","author":"Alpay","year":"2010","journal-title":"Eur J Clin Pharmacol"},{"issue":"3","key":"2021120900275503500_B4","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.jaapos.2004.01.004","article-title":"Cycloplegic and mydriatic agents for routine ophthalmologic examination: a survey of pediatric ophthalmologists.","volume":"8","author":"Patel","year":"2004","journal-title":"J AAPOS"},{"key":"2021120900275503500_B5","unstructured":"Available at www.mdconsult.com\/das\/pharm\/body\/334959483-97\/1246850528\/full\/1277. 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Results of pilot study and a double-blind study.","volume":"55","author":"Binkhorst","year":"1963","journal-title":"Am J Ophthalmol"},{"key":"2021120900275503500_B8","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1111\/j.1440-1754.1990.tb02399.x","article-title":"Seizures associated with 1% cyclopentolate eyedrops.","volume":"28","author":"Fitzgerald","year":"1990","journal-title":"J Paediatr Child Health"},{"issue":"4","key":"2021120900275503500_B9","first-page":"347","article-title":"Anaphylactic reaction due to cyclopentolate in a 4-year-old child.","volume":"20","author":"Tayman","year":"2010","journal-title":"J Investig Allergol Clin Immunol"},{"key":"2021120900275503500_B10","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1185\/146300905X75334","article-title":"Systemic toxicity with topical ophthalmic medications in children.","volume":"7","author":"Gray","year":"2006","journal-title":"Paediatr Perinat Drug Ther"},{"issue":"2","key":"2021120900275503500_B11","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1097\/MOP.0b013e32802c7be1","article-title":"Physostigmine: is there a role for this antidote in pediatric poisonings?","volume":"19","author":"Frascogna","year":"2007","journal-title":"Curr Opin Pediatr"}],"container-title":["Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/publications.aap.org\/pediatrics\/article-pdf\/130\/3\/e703\/1087727\/peds_2011-3038.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/publications.aap.org\/pediatrics\/article-pdf\/130\/3\/e703\/1087727\/peds_2011-3038.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,9]],"date-time":"2021-12-09T04:37:04Z","timestamp":1639024624000},"score":1,"resource":{"primary":{"URL":"https:\/\/publications.aap.org\/pediatrics\/article\/130\/3\/e703\/30179\/Use-of-Physostigmine-for-Cyclopentolate-Overdose"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,9,1]]},"references-count":11,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2012,9,1]]},"published-print":{"date-parts":[[2012,9,1]]}},"URL":"https:\/\/doi.org\/10.1542\/peds.2011-3038","relation":{},"ISSN":["0031-4005","1098-4275"],"issn-type":[{"type":"print","value":"0031-4005"},{"type":"electronic","value":"1098-4275"}],"subject":[],"published":{"date-parts":[[2012,9,1]]}}}