{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T08:03:37Z","timestamp":1792224217049,"version":"4.4.0"},"reference-count":30,"publisher":"American Academy of Pediatrics (AAP)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,6,1]]},"abstract":"<jats:sec>\n                  <jats:title>OBJECTIVE:<\/jats:title>\n                  <jats:p>To examine the influence of fetal and maternal characteristics on the survival of children born with Down syndrome.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS:<\/jats:title>\n                  <jats:p>We used prospectively collected population-based data on Down syndrome extracted from the UK Northern Congenital Abnormality Survey (NorCAS), January 1, 1985\u2013December 31, 2003, matched to hospital and national mortality records to January 29, 2008, to determine survival status of liveborn children. Survival to 20 years was estimated by using Kaplan-Meier methods. Cox proportional hazards regression was used to examine factors that predict survival.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS:<\/jats:title>\n                  <jats:p>A total of 1115 Down syndrome pregnancies were notified to NorCAS during the 19 years, a total prevalence of 16.8 (95% CI, 15.8\u201317.8) per 10\u2009000 live births and stillbirths. Of these, 5.4% resulted in a spontaneous fetal loss (late miscarriage \u226520 weeks and stillbirth), 31.7% in a termination of pregnancy, and 63.0% in a live birth. Survival status was known for 95.3% of live births; 16.6% resulted in a death. Year of birth (P &amp;lt; .001), gestational age at delivery (P &amp;lt; .001), standardized birth weight (P &amp;lt; .001), karyotype (P &amp;lt; .01), and presence of additional structural anomalies (P &amp;lt; .001) were significant predictors of survival. Infant gender, plurality, maternal age, and maternal deprivation were not significant predictors of survival.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS:<\/jats:title>\n                  <jats:p>These robust estimates of predictors of survival are important for the prenatal counseling of parents whose pregnancy is affected by Down syndrome and for health care planning for the future care needs of these children.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1542\/peds.2011-3051","type":"journal-article","created":{"date-parts":[[2012,5,22]],"date-time":"2012-05-22T00:21:46Z","timestamp":1337646106000},"page":"e1373-e1381","source":"Crossref","is-referenced-by-count":65,"title":["Predictors of Survival in Children Born With Down Syndrome: A Registry-Based Study"],"prefix":"10.1542","volume":"129","author":[{"given":"Judith","family":"Rankin","sequence":"first","affiliation":[{"name":"Institute of Health & Society, Newcastle University Newcastle upon Tyne, United Kingdom, and"},{"name":"Regional Maternity Survey Office, Newcastle upon Tyne, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter W.G.","family":"Tennant","sequence":"additional","affiliation":[{"name":"Institute of Health & Society, Newcastle University Newcastle upon Tyne, United Kingdom, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary","family":"Bythell","sequence":"additional","affiliation":[{"name":"Regional Maternity Survey Office, Newcastle upon Tyne, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark S.","family":"Pearce","sequence":"additional","affiliation":[{"name":"Institute of Health & Society, Newcastle University Newcastle upon Tyne, United Kingdom, and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"417","published-online":{"date-parts":[[2012,6,1]]},"reference":[{"issue":"11","key":"2021120903495245500_B1","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1002\/bdra.20294","article-title":"National estimates and race\/ethnic-specific variation of selected birth defects in the United States, 1999-2001.","volume":"76","author":"Canfield","year":"2006","journal-title":"Birth Defects Res A Clin Mol Teratol"},{"issue":"3","key":"2021120903495245500_B2","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1007\/BF00291175","article-title":"Life tables for Down syndrome.","volume":"82","author":"Baird","year":"1989","journal-title":"Hum Genet"},{"issue":"5","key":"2021120903495245500_B3","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1136\/adc.88.5.391","article-title":"Survival of children born with congenital anomalies.","volume":"88","author":"Dastgiri","year":"2003","journal-title":"Arch Dis Child"},{"issue":"3","key":"2021120903495245500_B4","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1002\/ajmg.a.20151","article-title":"First-year mortality rates for selected birth defects, Hawaii, 1986-1999.","volume":"119A","author":"Forrester","year":"2003","journal-title":"Am J Med Genet A"},{"issue":"5","key":"2021120903495245500_B5","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1002\/tera.1073","article-title":"Patterns of first-year survival among infants with selected congenital anomalies in Texas, 1995-1997.","volume":"64","author":"Nembhard","year":"2001","journal-title":"Teratology"},{"issue":"6","key":"2021120903495245500_B6","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1016\/j.jpeds.2006.01.010","article-title":"Survival in infants with Down syndrome, Metropolitan Atlanta, 1979-1998.","volume":"148","author":"Rasmussen","year":"2006","journal-title":"J Pediatr"},{"issue":"4","key":"2021120903495245500_B7","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1093\/ije\/26.4.822","article-title":"Ten-year survival of Down syndrome births.","volume":"26","author":"Hayes","year":"1997","journal-title":"Int J Epidemiol"},{"issue":"2","key":"2021120903495245500_B8","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1046\/j.1365-3016.2000.00252.x","article-title":"Survival of infants born with Down\u2019s syndrome: 1980-96.","volume":"14","author":"Leonard","year":"2000","journal-title":"Paediatr Perinat Epidemiol"},{"issue":"10","key":"2021120903495245500_B9","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1111\/j.1471-0528.2005.00660.x","article-title":"A population-based study of the prenatal diagnosis of congenital malformation over 16 years.","volume":"112","author":"Richmond","year":"2005","journal-title":"BJOG"},{"key":"2021120903495245500_B10","unstructured":"British Isles Network of Congenital Anomaly Registers. 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