{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T08:31:16Z","timestamp":1791016276773,"version":"4.1.0"},"reference-count":36,"publisher":"American Academy of Pediatrics (AAP)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,5,1]]},"abstract":"<jats:sec>\n                  <jats:title>OBJECTIVE:<\/jats:title>\n                  <jats:p>Adolescents and young adults born preterm have elevated blood pressure (BP). The objective of this study was to investigate if BP is elevated at 2.5 years of age after an extremely preterm birth (EXPT).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS:<\/jats:title>\n                  <jats:p>In a regional subset of the national population-based cohort Extremely Preterm Infants in Sweden Study, BP at 2.5 years of age was studied in 68 survivors of EXPT (gestational age: 23.6\u201326.9 weeks; mean \u00b1 SD birth weight: 810 \u00b1 164 g), and 65 matched controls born at term.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS:<\/jats:title>\n                  <jats:p>At follow-up at 2.5 years of corrected age, EXPT children had significantly higher systolic blood pressure (SBP) and diastolic blood pressure (DBP) z scores than controls born at term, according to pediatric BP nomograms by age, gender, and height. The proportion of SBP \u226590th percentile was 44% (30 of 68) in EXPT children and 23% (15 of 65) in controls (P = .01). In logistic regression analyses stratified according to gender, EXPT was associated with an odds ratio for a SBP \u226590th percentile of 3.32 (95% confidence interval: 1.25\u20138.81) among boys. The corresponding odds ratio among EXPT girls was 2.18 (95% confidence interval: 0.62\u20137.61). In EXPT children, SBP and DBP z scores were inversely correlated to catch-up growth from 36 weeks\u2019 postmenstrual age to follow-up at 2.5 years of age.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS:<\/jats:title>\n                  <jats:p>Children born extremely preterm have elevated office SBP and DBP at a corrected age of 2.5 years. This finding might have implications for their cardiovascular health later in life.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1542\/peds.2011-3177","type":"journal-article","created":{"date-parts":[[2012,4,3]],"date-time":"2012-04-03T00:20:28Z","timestamp":1333412428000},"page":"e1199-e1204","source":"Crossref","is-referenced-by-count":75,"title":["High Blood Pressure in 2.5-Year-Old Children Born Extremely Preterm"],"prefix":"10.1542","volume":"129","author":[{"given":"Anna-Karin Edstedt","family":"Bonamy","sequence":"first","affiliation":[{"name":"Department of Women\u2019s and Children\u2019s Health,"},{"name":"Unit for Clinical Epidemiology, Department of Medicine Solna, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin","family":"K\u00e4ll\u00e9n","sequence":"additional","affiliation":[{"name":"Center of Reproduction Epidemiology, Institute of Clinical Sciences, University of Lund, Lund, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikael","family":"Norman","sequence":"additional","affiliation":[{"name":"Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden; and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"417","published-online":{"date-parts":[[2012,5,1]]},"reference":[{"issue":"8","key":"2022051611133324300_B1","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1111\/j.1651-2227.2008.00890.x","article-title":"Preterm birth and maternal smoking in pregnancy are strong risk factors for aortic narrowing in adolescence.","volume":"97","author":"Edstedt Bonamy","year":"2008","journal-title":"Acta Paediatr"},{"issue":"4","key":"2022051611133324300_B2","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1093\/ije\/dym067","article-title":"Cardiovascular risk factors at age 30 following pre-term birth.","volume":"36","author":"Dalziel","year":"2007","journal-title":"Int J Epidemiol"},{"issue":"20","key":"2022051611133324300_B3","doi-asserted-by":"crossref","first-page":"2053","DOI":"10.1056\/NEJMoa067187","article-title":"Glucose regulation in young adults with very low birth weight.","volume":"356","author":"Hovi","year":"2007","journal-title":"N Engl J Med"},{"issue":"22","key":"2022051611133324300_B4","doi-asserted-by":"crossref","first-page":"3430","DOI":"10.1161\/CIRCULATIONAHA.105.540906","article-title":"Risk of high blood pressure among young men increases with the degree of immaturity at birth.","volume":"112","author":"Johansson","year":"2005","journal-title":"Circulation"},{"issue":"2","key":"2022051611133324300_B5","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1542\/peds.2007-2012","article-title":"Infant and childhood growth patterns, insulin sensitivity, and blood pressure in prematurely born young adults.","volume":"122","author":"Rotteveel","year":"2008","journal-title":"Pediatrics"},{"issue":"12","key":"2022051611133324300_B6","doi-asserted-by":"crossref","first-page":"1812","DOI":"10.1111\/j.1651-2227.2010.01926.x","article-title":"Early predictors of hypertension in prematurely born adolescents.","volume":"99","author":"Vohr","year":"2010","journal-title":"Acta Paediatr"},{"issue":"2","key":"2022051611133324300_B7","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1542\/peds.111.2.252","article-title":"Blood pressure in late adolescence and very low birth weight.","volume":"111","author":"Doyle","year":"2003","journal-title":"Pediatrics"},{"issue":"3\u20134","key":"2022051611133324300_B8","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1007\/s004670000473","article-title":"Increased blood pressure but normal renal function in adult women born preterm.","volume":"15","author":"Kistner","year":"2000","journal-title":"Pediatr Nephrol"},{"issue":"4","key":"2022051611133324300_B9","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1203\/01.PDR.0000180551.93470.56","article-title":"Blood pressure among very low birth weight (&lt;1.5 kg) young adults.","volume":"58","author":"Hack","year":"2005","journal-title":"Pediatr Res"},{"issue":"7","key":"2022051611133324300_B10","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1093\/aje\/kwq440","article-title":"Risk of hypertension among young adults who were born preterm: a Swedish national study of 636,000 births.","volume":"173","author":"Crump","year":"2011","journal-title":"Am J Epidemiol"},{"issue":"3","key":"2022051611133324300_B11","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1542\/peds.2005-0309","article-title":"Is blood pressure increased 19 years after intrauterine growth restriction and preterm birth? 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