{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T12:39:07Z","timestamp":1791895147185,"version":"4.3.4"},"reference-count":20,"publisher":"American Academy of Pediatrics (AAP)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,8,1]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND AND OBJECTIVE:<\/jats:title>\n                    <jats:p>Using light-emitting diodes during conventional phototherapy, it is possible to reduce the distance from light source to infant, thus increasing light irradiance. The objective of this study was to search for a \u201csaturation point\u201d (ie, an irradiation level above which there is no further decrease in total serum bilirubin [TsB]). This was a prospective randomized study performed in the NICU of Aalborg Hospital, Denmark.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>One hundred fifty-one infants (gestational age \u226533 weeks) with uncomplicated hyperbilirubinemia were randomized to 1 of 4 distances from the phototherapy device to the mattress (20, 29, 38, and 47 cm). TsB was measured before and after 24 hours of phototherapy and irradiance every eighth hour. Main outcome was 24-hour decrease of TsB expressed in percent, (\u2206 TsB0\u201324, difference between TsB0 and TsB24 [%]).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>A highly significant linear relation was seen between light irradiance and \u2206 TsB0\u201324 (%) (P &amp;lt; .001): when the irradiance increased from 20 to 55 \u03bcW\/cm2\/nm, \u2206 TsB0\u201324 (%) increased from approximately 30% to 50%. In addition, smooth regression showed no tendency for \u2206 TsB0\u201324 (%) to level off as irradiance increased. \u2206 TsB0\u201324 (%) was negatively correlated to birth weight and positively to formula volume. Average weight gain during phototherapy was 1%, independent of light irradiance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>By using light-emitting diodes, we found a linear relation between light irradiance in the range of 20 to 55 \u03bcW\/cm2\/nm and a decrease in TsB after 24 hours of therapy, with no evidence of a saturation point.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1542\/peds.2011-3235","type":"journal-article","created":{"date-parts":[[2012,7,17]],"date-time":"2012-07-17T09:24:54Z","timestamp":1342517094000},"page":"e352-e357","source":"Crossref","is-referenced-by-count":51,"title":["Dose-Response Relationship of Phototherapy for Hyperbilirubinemia"],"prefix":"10.1542","volume":"130","author":[{"given":"Pernille Kure","family":"Vandborg","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Aalborg Hospital, Aarhus University Hospital, Aalborg, Denmark; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo Moelholm","family":"Hansen","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Copenhagen University Hospital, Rigshospitalet, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gorm","family":"Greisen","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Copenhagen University Hospital, Rigshospitalet, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Finn","family":"Ebbesen","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Aalborg Hospital, Aarhus University Hospital, Aalborg, Denmark; and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"417","published-online":{"date-parts":[[2012,8,1]]},"reference":[{"issue":"4","key":"2021120821053985600_B1","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1111\/j.1651-2227.2011.02170.x","article-title":"High-intensity phototherapy for the treatment of severe nonhaemolytic neonatal hyperbilirubinemia.","volume":"100","author":"de Carvalho","year":"2011","journal-title":"Acta Paediatr"},{"issue":"6","key":"2021120821053985600_B2","doi-asserted-by":"crossref","first-page":"1674","DOI":"10.1172\/JCI113006","article-title":"Rapid clearance of a structural isomer of bilirubin during phototherapy.","volume":"79","author":"Ennever","year":"1987","journal-title":"J Clin Invest"},{"issue":"6","key":"2021120821053985600_B3","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1203\/PDR.0b013e3181dcedc0","article-title":"Early isomerization of bilirubin in phototherapy of neonatal jaundice.","volume":"67","author":"Mreihil","year":"2010","journal-title":"Pediatr Res"},{"issue":"3","key":"2021120821053985600_B4","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1053\/j.semperi.2010.02.008","article-title":"Phototherapy for neonatal jaundice\u2014therapeutic effects on more than one level?","volume":"34","author":"Ruud Hansen","year":"2010","journal-title":"Semin Perinatol"},{"key":"2021120821053985600_B5","doi-asserted-by":"crossref","first-page":"S93","DOI":"10.1038\/sj.jp.7210642","article-title":"Phototherapy\u2014traditional and nontraditional.","volume":"21","author":"Maisels","year":"2001","journal-title":"J Perinatol"},{"issue":"3","key":"2021120821053985600_B6","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1542\/peds.2011-1494","article-title":"Committee on Fetus and Newborn; American Academy of Pediatrics. 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