{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T19:36:43Z","timestamp":1792697803634,"version":"4.5.0"},"reference-count":40,"publisher":"American Academy of Pediatrics (AAP)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,10,1]]},"abstract":"<jats:sec>\n                  <jats:title>BACKGROUND AND OBJECTIVES:<\/jats:title>\n                  <jats:p>Preterm birth (PTB) and congenital heart defect (CHD) are 2 major causes of mortality and disability of perinatal origin. There are limited data on the relation between CHD and PTB. Our objective was to use population-based data to estimate the risk of PTB in newborns with CHD and to study specific associations between categories of CHD and PTB.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS:<\/jats:title>\n                  <jats:p>We used data from a population-based cohort study of CHD (EPId\u00e9miologique sur le devenir des enfants porteurs de CARDiopathies cong\u00e9nitales study), including 2189 live births with CHD (excluding isolated atrial septal defects) born between 2005 and 2008. We categorized CHD by using an anatomic and clinical classification. Data from the French National Perinatal Survey of 2003 were used to compare PTB in the EPId\u00e9miologique sur le devenir des enfants porteurs de CARDiopathies cong\u00e9nitales study to that of the general population.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS:<\/jats:title>\n                  <jats:p>Of the newborns with CHD, 13.5% were preterm. The odds of PTB were twofold higher than for the general population (odds ratio 2.0, 95% confidence interval 1.6\u20132.5), essentially due to an increase in spontaneous PTB for newborns with CHD. The risk of PTB associated with CHD persisted after exclusion of chromosomal or other anomalies. There were significant variations in risk of PTB across the categories of CHD after adjustment for known risk factors of PTB and factors related to medical management of pregnancy and delivery.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS:<\/jats:title>\n                  <jats:p>We found a higher risk of PTB in newborns with CHD, which was essentially due to spontaneous PTB. Risk of PTB varied for categories of CHD. Our finding may be helpful for generating hypotheses about the developmental links between CHD and PTB.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1542\/peds.2011-3279","type":"journal-article","created":{"date-parts":[[2012,9,4]],"date-time":"2012-09-04T00:25:58Z","timestamp":1346718358000},"page":"e829-e837","source":"Crossref","is-referenced-by-count":95,"title":["Preterm Birth and Congenital Heart Defects: A Population-based Study"],"prefix":"10.1542","volume":"130","author":[{"given":"Enora","family":"Laas","sequence":"first","affiliation":[{"name":"INSERM, UMR S953, Recherche \u00c9pid\u00e9miologique sur la Sant\u00e9 P\u00e9rinatale et la Sant\u00e9 des Femmes et des Enfants, UPMC, Universit\u00e9 Paris-6, Paris, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"Lelong","sequence":"additional","affiliation":[{"name":"INSERM, UMR S953, Recherche \u00c9pid\u00e9miologique sur la Sant\u00e9 P\u00e9rinatale et la Sant\u00e9 des Femmes et des Enfants, UPMC, Universit\u00e9 Paris-6, Paris, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne-Claire","family":"Thieulin","sequence":"additional","affiliation":[{"name":"INSERM, UMR S953, Recherche \u00c9pid\u00e9miologique sur la Sant\u00e9 P\u00e9rinatale et la Sant\u00e9 des Femmes et des Enfants, UPMC, Universit\u00e9 Paris-6, Paris, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucile","family":"Houyel","sequence":"additional","affiliation":[{"name":"Service de Chirurgie des Cardiopathies Cong\u00e9nitales, H\u00f4pital Marie Lannelongue, Le Plessis Robinson, France; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Damien","family":"Bonnet","sequence":"additional","affiliation":[{"name":"Centre de R\u00e9f\u00e9rence M3C-Necker, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre-Yves","family":"Ancel","sequence":"additional","affiliation":[{"name":"INSERM, UMR S953, Recherche \u00c9pid\u00e9miologique sur la Sant\u00e9 P\u00e9rinatale et la Sant\u00e9 des Femmes et des Enfants, UPMC, Universit\u00e9 Paris-6, Paris, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilles","family":"Kayem","sequence":"additional","affiliation":[{"name":"INSERM, UMR S953, Recherche \u00c9pid\u00e9miologique sur la Sant\u00e9 P\u00e9rinatale et la Sant\u00e9 des Femmes et des Enfants, UPMC, Universit\u00e9 Paris-6, Paris, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Goffinet","sequence":"additional","affiliation":[{"name":"INSERM, UMR S953, Recherche \u00c9pid\u00e9miologique sur la Sant\u00e9 P\u00e9rinatale et la Sant\u00e9 des Femmes et des Enfants, UPMC, Universit\u00e9 Paris-6, Paris, France;"},{"name":"Maternit\u00e9 Port Royal, H\u00f4pital Cochin Saint-Vincent-de-Paul, Assistance Publique H\u00f4pitaux de Paris, Universit\u00e9 Paris-Descartes, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Babak","family":"Khoshnood","sequence":"additional","affiliation":[{"name":"INSERM, UMR S953, Recherche \u00c9pid\u00e9miologique sur la Sant\u00e9 P\u00e9rinatale et la Sant\u00e9 des Femmes et des Enfants, UPMC, Universit\u00e9 Paris-6, Paris, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"417","published-online":{"date-parts":[[2012,10,1]]},"reference":[{"issue":"8","key":"2021120823512057600_B1","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1161\/CIRCULATIONAHA.110.958405","article-title":"Congenital heart defects in Europe: prevalence and perinatal mortality, 2000 to 2005.","volume":"123","author":"Dolk","year":"2011","journal-title":"Circulation"},{"issue":"1","key":"2021120823512057600_B2","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1542\/peds.2004-0516","article-title":"Trends in prenatal diagnosis, pregnancy termination, and perinatal mortality of newborns with congenital heart disease in France, 1983\u20132000: a population-based evaluation.","volume":"115","author":"Khoshnood","year":"2005","journal-title":"Pediatrics"},{"issue":"5","key":"2021120823512057600_B3","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/S0929-693X(00)89004-1","article-title":"Trends in infant mortality in France: frequency and causes from 1950 to 1997 [in French]","volume":"7","author":"Hatton","year":"2000","journal-title":"Arch Pediatr"},{"issue":"4","key":"2021120823512057600_B4","first-page":"620","article-title":"Infant mortality from congenital malformations in the United States, 1970\u20131997.","volume":"98","author":"Lee","year":"2001","journal-title":"Obstet Gynecol"},{"issue":"4","key":"2021120823512057600_B5","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1016\/j.clp.2005.09.008","article-title":"Long-term and developmental outcomes of children with complex congenital heart disease.","volume":"32","author":"Brown","year":"2005","journal-title":"Clin Perinatol"},{"issue":"1","key":"2021120823512057600_B6","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1067\/mpd.2003.mpd0354","article-title":"Neurologic and developmental morbidity in children with complex congenital heart disease.","volume":"142","author":"Wernovsky","year":"2003","journal-title":"J Pediatr"},{"key":"2021120823512057600_B7"},{"issue":"2","key":"2021120823512057600_B8","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1097\/WCO.0b013e3282f88bb4","article-title":"Neurodevelopmental outcomes of preterm infants.","volume":"21","author":"Allen","year":"2008","journal-title":"Curr Opin Neurol"},{"issue":"9615","key":"2021120823512057600_B9","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1016\/S0140-6736(08)60380-3","article-title":"Neurodevelopmental disabilities and special care of 5-year-old children born before 33 weeks of gestation (the EPIPAGE study): a longitudinal cohort study.","volume":"371","author":"Larroque","year":"2008","journal-title":"Lancet"},{"issue":"6","key":"2021120823512057600_B10","doi-asserted-by":"crossref","first-page":"e833","DOI":"10.1542\/peds.2005-0397","article-title":"Cardiovascular malformations among preterm infants.","volume":"116","author":"Tanner","year":"2005","journal-title":"Pediatrics"},{"issue":"1\u20132","key":"2021120823512057600_B11","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/0028-2243(84)90028-5","article-title":"The antenatal diagnosis of Potter syndrome (Potter sequence). 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