{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T12:10:42Z","timestamp":1785499842755,"version":"3.56.0"},"reference-count":18,"publisher":"American Academy of Pediatrics (AAP)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,8,1]]},"abstract":"<jats:p>Infants undergoing therapeutic hypothermia for hypoxic ischemic encephalopathy are at risk for rebound seizures during and after the rewarming phase. We report a term male infant who was cooled for hypoxic ischemic encephalopathy. He developed electrographic seizures for the first time during the warming phase, which continued in the hours after rewarming. The seizures stopped within 30 minutes of recooling to 33.5\u00b0C without anticonvulsant medication. He was uneventfully cooled for an additional 24 hours and then rewarmed with no recurrence of seizures. Hypothermia appeared to have an antiepileptic effect in this case and may be worthy of additional investigation as an adjunct to antiepileptic drug therapy in newborns.<\/jats:p>","DOI":"10.1542\/peds.2011-3496","type":"journal-article","created":{"date-parts":[[2012,7,3]],"date-time":"2012-07-03T03:07:04Z","timestamp":1341284824000},"page":"e451-e455","source":"Crossref","is-referenced-by-count":26,"title":["Recooling for Rebound Seizures After Rewarming in Neonatal Encephalopathy"],"prefix":"10.1542","volume":"130","author":[{"given":"Giles S.","family":"Kendall","sequence":"first","affiliation":[{"name":"Division of Academic Neonatology, Institute of Women\u2019s Health, University College London, London, United Kingdom; and"},{"name":"Neonatal Intensive Care, University College Hospital, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean","family":"Mathieson","sequence":"additional","affiliation":[{"name":"Division of Academic Neonatology, Institute of Women\u2019s Health, University College London, London, United Kingdom; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith","family":"Meek","sequence":"additional","affiliation":[{"name":"Division of Academic Neonatology, Institute of Women\u2019s Health, University College London, London, United Kingdom; and"},{"name":"Neonatal Intensive Care, University College Hospital, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janet M.","family":"Rennie","sequence":"additional","affiliation":[{"name":"Division of Academic Neonatology, Institute of Women\u2019s Health, University College London, London, United Kingdom; and"},{"name":"Neonatal Intensive Care, University College Hospital, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"417","published-online":{"date-parts":[[2012,8,1]]},"reference":[{"issue":"93","key":"2021120821053654700_B1","doi-asserted-by":"crossref","first-page":"c363","DOI":"10.1136\/bmj.c363","article-title":"Neurological outcomes at 18 months of age after moderate hypothermia for perinatal hypoxic ischaemic encephalopathy: synthesis and meta-analysis of trial data.","volume":"340","author":"Edwards","year":"2010","journal-title":"BMJ"},{"key":"2021120821053654700_B2","unstructured":"National Institute of Health and Clinical Excellence. IPG347 Therapeutic hypothermia with intracorporeal temperature monitoring for hypoxic perinatal brain injury. May 2010. Available at: www.nice.org.uk\/nicemedia\/live\/11315\/48809\/48809.pdf. 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