{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T22:36:35Z","timestamp":1784932595947,"version":"3.55.0"},"reference-count":25,"publisher":"American Academy of Pediatrics (AAP)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,12,1]]},"abstract":"<jats:sec><jats:title>OBJECTIVE:<\/jats:title><jats:p>To determine whether enteral application of the osmotic contrast agent Gastrografin accelerates complete meconium excretion and improves feeding tolerance in very low birth weight infants.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS:<\/jats:title><jats:p>This study was a stratified, randomized, placebo-controlled trial in premature infants with a birth weight &amp;lt;1500 g and a gestational age &amp;lt;32 weeks who received 3 mL\/kg Gastrografin diluted 1:3 with water within their first 24 hours of life, or placebo.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS:<\/jats:title><jats:p>Passage of last meconium occurred after a median of 7 days (95% confidence interval: 6\u20139 days, n = 39) in the intervention group and after 8 days (95% confidence interval: 7\u201310 days, n = 39) in the control group (P = .61); however, Gastrografin application was associated with a 7.5-day shorter time to full enteral feedings, a 24-day shorter stay in the NICU, and a 17-day reduction in the overall hospital stay in the intervention group compared with the control group. A numerically higher incidence of necrotizing enterocolitis (21%) was observed in the intervention group, however.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS:<\/jats:title><jats:p>Gastrografin application did not accelerate meconium evacuation, but the higher stool frequency during the first week of life had a beneficial effect on the time to full enteral feedings and later hospital stay; however, it may increase the necrotizing enterocolitis risk. Further investigations are needed with modified protocols, and the prophylactic use of Gastrografin cannot currently be recommended without further clinical trials.<\/jats:p><\/jats:sec>","DOI":"10.1542\/peds.2011-3634","type":"journal-article","created":{"date-parts":[[2012,11,27]],"date-time":"2012-11-27T05:29:09Z","timestamp":1353994149000},"page":"e1600-e1606","source":"Crossref","is-referenced-by-count":39,"title":["The Effect of an Osmotic Contrast Agent on Complete Meconium Evacuation in Preterm Infants"],"prefix":"10.1542","volume":"130","author":[{"given":"Nadja","family":"Haiden","sequence":"first","affiliation":[{"name":"Division of Neonatology, Intensive Care and Neuropediatrics, Department of Pediatrics, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florentine","family":"Norooz","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Intensive Care and Neuropediatrics, Department of Pediatrics, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathrin","family":"Klebermass-Schrehof","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Intensive Care and Neuropediatrics, Department of Pediatrics, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna Sophie","family":"Horak","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Intensive Care and Neuropediatrics, Department of Pediatrics, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernd","family":"Jilma","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelika","family":"Berger","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Intensive Care and Neuropediatrics, Department of Pediatrics, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Repa","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Intensive Care and Neuropediatrics, Department of Pediatrics, and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"417","published-online":{"date-parts":[[2012,12,1]]},"reference":[{"issue":"5","key":"2021120823573735700_B1","doi-asserted-by":"crossref","first-page":"F376","DOI":"10.1136\/adc.2008.138024","article-title":"Duration of meconium passage in preterm and term infants.","volume":"93","author":"Bekkali","year":"2008","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"2021120823573735700_B2"},{"issue":"6","key":"2021120823573735700_B3","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1177\/0148607193017006537","article-title":"Meconium passage in very-low-birth-weight infants.","volume":"17","author":"Meetze","year":"1993","journal-title":"JPEN J Parenter Enteral Nutr"},{"issue":"4","key":"2021120823573735700_B4","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1111\/j.1651-2227.2001.tb00441.x","article-title":"Meconium passage in extremely low birthweight infants and its relation to very early enteral nutrition.","volume":"90","author":"Mihatsch","year":"2001","journal-title":"Acta Paediatr"},{"issue":"2","key":"2021120823573735700_B5","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1097\/MPG.0b013e31802c685a","article-title":"Small volume enemas do not accelerate meconium evacuation in very low birth weight infants.","volume":"44","author":"Haiden","year":"2007","journal-title":"J Pediatr Gastroenterol Nutr"},{"issue":"5","key":"2021120823573735700_B6","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1016\/j.jpedsurg.2004.01.027","article-title":"Meconium obstruction in extremely low-birth-weight neonates: guidelines for diagnosis and management.","volume":"39","author":"Emil","year":"2004","journal-title":"J Pediatr Surg"},{"issue":"11","key":"2021120823573735700_B7","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1136\/adc.61.11.1128","article-title":"Gastrografin in acute meconium ileus equivalent.","volume":"61","author":"O\u2019Halloran","year":"1986","journal-title":"Arch Dis Child"},{"key":"2021120823573735700_B8","unstructured":"Randomization Web site. 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