{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,26]],"date-time":"2026-01-26T13:54:00Z","timestamp":1769435640777,"version":"3.49.0"},"reference-count":15,"publisher":"American Academy of Pediatrics (AAP)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,2,1]]},"abstract":"\n OBJECTIVE:<\/jats:title>\n Therapeutic hypothermia (TH) for neonatal encephalopathy is becoming widely available in clinical practice. The goal of this collaborative was to create and implement an evidence-based standard-of-care approach to neonatal encephalopathy, deliver consistent care, and optimize outcomes.<\/jats:p>\n <\/jats:sec>\n \n METHODS:<\/jats:title>\n The quality improvement process identified and used the Model for Improvement as a framework for improvement efforts. This was a Vermont Oxford Network Collaborative focused on optimizing TH in the treatment of neonatal encephalopathy. By using an evidence-based approach, Potentially Better Practices were developed by the topic expert, modified by the collaborative, and implemented at each hospital. These included the following: timely identification of at-risk infants, coordination with referring hospitals to ensure TH was available within 6 hours after birth, staff education for both local and referring hospitals, nonsedated MRI, incorporating amplitude-integrated EEG into a TH protocol, and ensuring standard neurodevelopmental follow-up of infants. Each center used these practices to develop a matrix for implementation.<\/jats:p>\n <\/jats:sec>\n \n RESULTS:<\/jats:title>\n Local self-assessments directed the implementation and adaptation of the Potentially Better Practices at each center. Resources, based on common identified barriers, were developed and shared among the group.<\/jats:p>\n <\/jats:sec>\n \n CONCLUSIONS:<\/jats:title>\n The implementation of a TH program to improve the consistency of care for patients in NICUs is feasible using standard-quality improvement methodology. The successful introduction of new interventions such as TH to the NICU culture requires a collaborative multidisciplinary team, use of a systematic quality improvement process, and perseverance.<\/jats:p>\n <\/jats:sec>","DOI":"10.1542\/peds.2012-0891","type":"journal-article","created":{"date-parts":[[2013,1,8]],"date-time":"2013-01-08T23:12:31Z","timestamp":1357686751000},"page":"e591-e603","source":"Crossref","is-referenced-by-count":47,"title":["Optimizing Therapeutic Hypothermia for Neonatal Encephalopathy"],"prefix":"10.1542","volume":"131","author":[{"given":"Steven L.","family":"Olsen","sequence":"first","affiliation":[{"name":"Section of Neonatal-Perinatal Medicine, Department of Pediatrics, The Children\u2019s Mercy Hospitals and Clinics, University of Missouri-Kansas City School of Medicine, Kansas City, Missouri;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitchell","family":"DeJonge","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Helen DeVos Children\u2019s Hospital, Grand Rapids, Michigan;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alex","family":"Kline","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Neonatology, Inova Fairfax Hospital for Children, Falls Church, Virginia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ellina","family":"Liptsen","sequence":"additional","affiliation":[{"name":"Colorado Permanente Medical Group, Department of Pediatrics, Exempla St Joseph Hospital, Denver, Colorado;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dongli","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Santa Clara Valley Medical Center, San Jose, California; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Betsi","family":"Anderson","sequence":"additional","affiliation":[{"name":"Section of Neonatal-Perinatal Medicine, Department of Pediatrics, The Children\u2019s Mercy Hospitals and Clinics, University of Missouri-Kansas City School of Medicine, Kansas City, Missouri;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amit","family":"Mathur","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, St Louis Children\u2019s Hospital, Washington University School of Medicine, St Louis, Missouri"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"417","published-online":{"date-parts":[[2013,2,1]]},"reference":[{"issue":"9460","key":"2021120903263964500_B1","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/S0140-6736(05)17946-X","article-title":". 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Whole body hypothermia for the treatment of perinatal asphyxial encephalopathy: a randomised controlled trial.","author":"Azzopardi","year":"2008","journal-title":"BMC Pediatr"},{"issue":"10","key":"2021120903263964500_B5","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1001\/archpedi.161.10.951","article-title":"Hypothermia to treat neonatal hypoxic ischemic encephalopathy: systematic review.","volume":"161","author":"Shah","year":"2007","journal-title":"Arch Pediatr Adolesc Med"},{"issue":"7","key":"2021120903263964500_B6","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/1471-2431-7-30","article-title":"A systemic review of cooling for neuroprotection with hypoxic ischemic encephalopathy\u2014are we there yet?","author":"Schulzke","year":"2007","journal-title":"BMC Pediatr"},{"issue":"4","key":"2021120903263964500_B7","doi-asserted-by":"crossref","DOI":"10.1002\/14651858.CD003311.pub2","article-title":"Cooling for newborns with hypoxic ischemic encephalopathy.","author":"Jacobs","year":"2007","journal-title":"Cochrane Database Syst Rev"},{"issue":"5","key":"2021120903263964500_B8","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.siny.2010.02.003","article-title":"Hypothermia: a systematic review and meta-analysis of clinical trials.","volume":"15","author":"Shah","year":"2010","journal-title":"Semin Fetal Neonatal Med"},{"key":"2021120903263964500_B9","volume-title":"Crossing the Quality Chasm: A New Health System for the 21st Century","author":"Institute of Medicine","year":"2001"},{"key":"2021120903263964500_B10"},{"issue":"5","key":"2021120903263964500_B11","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1038\/jp.2009.168","article-title":"Therapeutic hypothermia on neonatal transport: 4-year experience in a single NICU.","volume":"30","author":"Fairchild","year":"2010","journal-title":"J Perinatol"},{"issue":"3","key":"2021120903263964500_B12","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1097\/JPN.0b013e3181e8d566","article-title":"Magnetic resonance imaging studies without sedation in the neonatal intensive care unit: safe and efficient.","volume":"24","author":"Haney","year":"2010","journal-title":"J Perinat Neonatal Nurs"},{"issue":"1","key":"2021120903263964500_B13","doi-asserted-by":"crossref","first-page":"e131","DOI":"10.1542\/peds.2009-2938","article-title":"Effect of hypothermia on amplitude-integrated electroencephalogram in infants with asphyxia.","volume":"126","author":"Thoresen","year":"2010","journal-title":"Pediatrics"},{"issue":"2","key":"2021120903263964500_B14","doi-asserted-by":"crossref","first-page":"e358","DOI":"10.1542\/peds.2009-0136","article-title":"Effect of treatment of subclinical neonatal seizures detected with aEEG: randomized, controlled trial.","volume":"125","author":"van Rooij","year":"2010","journal-title":"Pediatrics"},{"issue":"2","key":"2021120903263964500_B15","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1038\/sj.jp.7211882","article-title":"Should amplitude-integrated electroencephalography be used to identify infants suitable for hypothermic neuroprotection?","volume":"28","author":"Sarkar","year":"2008","journal-title":"J Perinatol"}],"container-title":["Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/publications.aap.org\/pediatrics\/article-pdf\/131\/2\/e591\/1088620\/peds_2012-0891.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/publications.aap.org\/pediatrics\/article-pdf\/131\/2\/e591\/1088620\/peds_2012-0891.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,9]],"date-time":"2021-12-09T18:11:47Z","timestamp":1639073507000},"score":1,"resource":{"primary":{"URL":"https:\/\/publications.aap.org\/pediatrics\/article\/131\/2\/e591\/31906\/Optimizing-Therapeutic-Hypothermia-for-Neonatal"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,2,1]]},"references-count":15,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2013,2,1]]},"published-print":{"date-parts":[[2013,2,1]]}},"URL":"https:\/\/doi.org\/10.1542\/peds.2012-0891","relation":{},"ISSN":["0031-4005","1098-4275"],"issn-type":[{"value":"0031-4005","type":"print"},{"value":"1098-4275","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,2,1]]}}}