{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T12:28:57Z","timestamp":1790684937316,"version":"4.1.0"},"reference-count":19,"publisher":"American Academy of Pediatrics (AAP)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,5,1]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND:<\/jats:title>\n                    <jats:p>\u201cAmpicillin rash,\u201d a phenomenon unique to patients with Epstein-Barr virus acute infectious mononucleosis (AIM) treated with ampicillin, was first reported in the 1960s. The incidence was estimated as being between 80% and 100%, and the figures have not been reviewed since those first accounts. We sought to establish the current incidence of rash associated with antibiotic treatment among children with AIM.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>A retrospective study of all hospitalized children diagnosed as having AIM based upon positive Epstein-Barr virus serology in 2 pediatric tertiary medical centers in Israel.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>Of the 238 children who met the study entry criteria during the study period, 173 were treated with antibiotics. Fifty-seven (32.9%) of the subjects treated with antibiotics had a rash during their illness compared with 15 (23.1%) in untreated patients (P = .156; not significant). Amoxicillin was associated with the highest incidence of antibiotic-induced rash occurrence (29.5%, 95% confidence interval: 18.52\u201342.57), but significantly lower than the 90% rate reported for ampicillin in past studies. Age, gender, ethnicity, and atopic or allergic history were not associated with the development of rash after antibiotic exposure. Among the laboratory data, only increased white blood cell counts were more prevalent among subjects who did not develop an antibiotic-induced rash.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>The incidence of rash in pediatric patients with AIM after treatment with the current oral aminopenicillin (amoxicillin) is much lower than originally reported.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1542\/peds.2012-1575","type":"journal-article","created":{"date-parts":[[2013,4,15]],"date-time":"2013-04-15T20:54:20Z","timestamp":1366059260000},"page":"e1424-e1427","source":"Crossref","is-referenced-by-count":117,"title":["Incidence of Rash After Amoxicillin Treatment in Children With Infectious Mononucleosis"],"prefix":"10.1542","volume":"131","author":[{"given":"Aluma","family":"Chovel-Sella","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Dana-Dwek Children\u2019s Hospital, Tel Aviv Sourasky Medical Center, Tel-Aviv, Israel, affiliated to the"},{"name":"Sackler Faculty of Medicine, Tel Aviv University Tel Aviv, Israel;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amir","family":"Ben Tov","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Dana-Dwek Children\u2019s Hospital, Tel Aviv Sourasky Medical Center, Tel-Aviv, Israel, affiliated to the"},{"name":"Sackler Faculty of Medicine, Tel Aviv University Tel Aviv, Israel;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Einat","family":"Lahav","sequence":"additional","affiliation":[{"name":"Sackler Faculty of Medicine, Tel Aviv University Tel Aviv, Israel;"},{"name":"Department of Pediatrics anddPediatric ICU, The Edmond and Lily Safra Children's Hospital, The Chaim Sheba Medical Center; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Orna","family":"Mor","sequence":"additional","affiliation":[{"name":"National HIV Reference Laboratory, Ministry of Health, Sheba Medical Center, Ramat Gan, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hagit","family":"Rudich","sequence":"additional","affiliation":[{"name":"National HIV Reference Laboratory, Ministry of Health, Sheba Medical Center, Ramat Gan, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gideon","family":"Paret","sequence":"additional","affiliation":[{"name":"Sackler Faculty of Medicine, Tel Aviv University Tel Aviv, Israel;"},{"name":"Department of Pediatrics anddPediatric ICU, The Edmond and Lily Safra Children's Hospital, The Chaim Sheba Medical Center; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shimon","family":"Reif","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Dana-Dwek Children\u2019s Hospital, Tel Aviv Sourasky Medical Center, Tel-Aviv, Israel, affiliated to the"},{"name":"Sackler Faculty of Medicine, Tel Aviv University Tel Aviv, Israel;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"417","published-online":{"date-parts":[[2013,5,1]]},"reference":[{"issue":"21","key":"2021120900055245500_B1","doi-asserted-by":"crossref","first-page":"1993","DOI":"10.1056\/NEJMcp1001116","article-title":"Infectious mononucleosis.","volume":"362","author":"Luzuriaga","year":"2010","journal-title":"N Engl J Med"},{"issue":"2","key":"2021120900055245500_B2","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1542\/pir.7-2-35","article-title":"The many faces of infectious mononucleosis: the spectrum of Epstein-Barr virus infection in children.","volume":"7","author":"Grose","year":"1985","journal-title":"Pediatr Rev"},{"issue":"10","key":"2021120900055245500_B3","doi-asserted-by":"crossref","first-page":"911.e1","DOI":"10.1016\/j.amjmed.2006.12.011","article-title":"Diagnostic evaluation of mononucleosis-like illnesses.","volume":"120","author":"Hurt","year":"2007","journal-title":"Am J Med."},{"key":"2021120900055245500_B4","volume-title":"Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases","author":"Mandell","year":"2005","edition":"6th ed."},{"key":"2021120900055245500_B5","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1016\/B978-1-4377-0755-7.00246-3","article-title":"Epstein-Barr virus","volume-title":"Nelson Textbook of Pediatrics","author":"Jenson","year":"2011","edition":"19th ed."},{"issue":"7","key":"2021120900055245500_B6","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1046\/j.1365-4362.2003.01699_1.x","article-title":"Eruption associated with amoxicillin in a patient with infectious mononucleosis.","volume":"42","author":"Leung","year":"2003","journal-title":"Int J Dermatol"},{"issue":"5","key":"2021120900055245500_B7","first-page":"330","article-title":"Making a rash diagnosis: amoxicillin therapy in infectious mononucleosis.","volume":"83","author":"Pauszek","year":"1990","journal-title":"Indiana Med"},{"issue":"5","key":"2021120900055245500_B8","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1542\/peds.40.5.910","article-title":"Skin rash with infectious mononucleosis and ampicillin.","volume":"40","author":"Patel","year":"1967","journal-title":"Pediatrics"},{"issue":"7527","key":"2021120900055245500_B9","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1016\/S0140-6736(67)91893-4","article-title":"Hypersensitivity reactions to antibacterial drugs in infectious mononucleosis.","volume":"2","author":"Pullen","year":"1967","journal-title":"Lancet"},{"issue":"7531","key":"2021120900055245500_B10","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.1016\/S0140-6736(67)93045-0","article-title":"Drug rashes in glandular fever.","volume":"2","author":"Brown","year":"1967","journal-title":"Lancet"},{"issue":"5647","key":"2021120900055245500_B11","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1136\/bmj.1.5647.846-b","article-title":"Ampicillin and urticaria.","volume":"1","author":"Knudsen","year":"1969","journal-title":"BMJ"},{"issue":"2","key":"2021120900055245500_B12","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1111\/j.1398-9995.1991.tb00560.x","article-title":"Delayed allergic reactions to beta-lactams. 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