{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T12:38:44Z","timestamp":1769171924794,"version":"3.49.0"},"reference-count":9,"publisher":"American Academy of Pediatrics (AAP)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,3,1]]},"abstract":"<jats:p>New noninvasive methods for monitoring cerebrovascular pressure reactivity coupled with a blood-based assay for brain-specific injury in preterm infants could allow early diagnosis of brain injury and set the stage for improved timing and effectiveness of interventions. Using an adaptation of near-infrared spectroscopy, we report a case of a very low birth weight infant undergoing hemoglobin volume index monitoring as a measure of cerebrovascular pressure reactivity. During the monitoring period, this infant demonstrated significant disturbances in cerebrovascular pressure reactivity that coincided with elevation of serum glial fibrillary acidic protein and new findings of brain injury on head ultrasound. This case report demonstrates the potential of emerging noninvasive monitoring methods to assist in both detection and therapeutic management to improve neurologic outcomes of the very low birth weight neonate.<\/jats:p>","DOI":"10.1542\/peds.2012-1702","type":"journal-article","created":{"date-parts":[[2013,2,19]],"date-time":"2013-02-19T13:03:39Z","timestamp":1361279019000},"page":"e950-e954","source":"Crossref","is-referenced-by-count":3,"title":["Detection of Neurologic Injury Using Vascular Reactivity Monitoring and Glial Fibrillary Acidic Protein"],"prefix":"10.1542","volume":"131","author":[{"given":"Christopher J.","family":"Rhee","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Section of Neonatology, and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathleen K.","family":"Kibler","sequence":"additional","affiliation":[{"name":"Department of Anesthesia, Critical Care Medicine and Pediatrics, Texas Children\u2019s Hospital, Baylor College of Medicine, Houston, Texas; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ken M.","family":"Brady","sequence":"additional","affiliation":[{"name":"Department of Anesthesia, Critical Care Medicine and Pediatrics, Texas Children\u2019s Hospital, Baylor College of Medicine, Houston, Texas; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Allen D.","family":"Everett","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Cardiology Division, and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ernest M.","family":"Graham","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Johns Hopkins University, Baltimore, Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dean B.","family":"Andropoulos","sequence":"additional","affiliation":[{"name":"Department of Anesthesia, Critical Care Medicine and Pediatrics, Texas Children\u2019s Hospital, Baylor College of Medicine, Houston, Texas; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. Blaine","family":"Easley","sequence":"additional","affiliation":[{"name":"Department of Anesthesia, Critical Care Medicine and Pediatrics, Texas Children\u2019s Hospital, Baylor College of Medicine, Houston, Texas; and"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"417","published-online":{"date-parts":[[2013,3,1]]},"reference":[{"issue":"1 pt 1","key":"2021120900320568800_B1","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1542\/peds.112.1.176","article-title":"Cerebral white matter injury of the premature infant\u2014more common than you think.","volume":"112","author":"Volpe","year":"2003","journal-title":"Pediatrics"},{"key":"2021120900320568800_B2"},{"issue":"5","key":"2021120900320568800_B3","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1097\/PCC.0b013e3181fe3ec7","article-title":"Glial fibrillary acidic protein as a brain injury biomarker in children undergoing extracorporeal membrane oxygenation.","volume":"12","author":"Bembea","year":"2011","journal-title":"Pediatr Crit Care Med"},{"issue":"11","key":"2021120900320568800_B4","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1038\/jp.2011.17","article-title":"Relationship between cerebrovascular dysautoregulation and arterial blood pressure in the premature infant.","volume":"31","author":"Gilmore","year":"2011","journal-title":"J Perinatol"},{"issue":"20","key":"2021120900320568800_B5","doi-asserted-by":"crossref","first-page":"2445","DOI":"10.1161\/CIR.0b013e31825b02ed","article-title":"Abstracts From the Emerging Science Series, April 25, 2012.","volume":"125","author":"Easley","year":"2012","journal-title":"Circulation"},{"issue":"9","key":"2021120900320568800_B6","doi-asserted-by":"crossref","first-page":"1957","DOI":"10.1161\/STROKEAHA.109.575167","article-title":"Monitoring cerebral blood flow pressure autoregulation in pediatric patients during cardiac surgery.","volume":"41","author":"Brady","year":"2010","journal-title":"Stroke"},{"issue":"5","key":"2021120900320568800_B7","doi-asserted-by":"crossref","first-page":"1820","DOI":"10.1161\/STROKEAHA.108.536094","article-title":"Cerebrovascular reactivity measured by near-infrared spectroscopy.","volume":"40","author":"Lee","year":"2009","journal-title":"Stroke"},{"issue":"11","key":"2021120900320568800_B8","doi-asserted-by":"crossref","first-page":"1951","DOI":"10.1089\/neu.2010.1388","article-title":"Noninvasive monitoring of cerebrovascular reactivity with near infrared spectroscopy in head-injured patients.","volume":"27","author":"Zweifel","year":"2010","journal-title":"J Neurotrauma"},{"key":"2021120900320568800_B9"}],"container-title":["Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/publications.aap.org\/pediatrics\/article-pdf\/131\/3\/e950\/1088973\/peds_2012-1702.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/publications.aap.org\/pediatrics\/article-pdf\/131\/3\/e950\/1088973\/peds_2012-1702.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,9]],"date-time":"2021-12-09T06:30:12Z","timestamp":1639031412000},"score":1,"resource":{"primary":{"URL":"https:\/\/publications.aap.org\/pediatrics\/article\/131\/3\/e950\/30923\/Detection-of-Neurologic-Injury-Using-Vascular"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,3,1]]},"references-count":9,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2013,3,1]]},"published-print":{"date-parts":[[2013,3,1]]}},"URL":"https:\/\/doi.org\/10.1542\/peds.2012-1702","relation":{},"ISSN":["0031-4005","1098-4275"],"issn-type":[{"value":"0031-4005","type":"print"},{"value":"1098-4275","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,3,1]]}}}