{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T20:13:41Z","timestamp":1769631221020,"version":"3.49.0"},"reference-count":13,"publisher":"American Academy of Pediatrics (AAP)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,2,1]]},"abstract":"<jats:sec>\n                  <jats:title>OBJECTIVE:<\/jats:title>\n                  <jats:p>To determine if iron supplementation of 2 mg\/kg per day, in addition to routine iron-fortified formula or mother's milk, increased the hematocrit (Hct) at 36 weeks' postmenstrual age (PMA).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS::<\/jats:title>\n                  <jats:p>Infants with a birth weight &amp;lt;1500 g who reached 120 mL\/kg per day of feedings before 32 weeks' PMA were randomly assigned to iron (multivitamin with iron) or control (multivitamin) from enrollment until 36 weeks' PMA (or discharge, if sooner). Investigators and caregivers were masked. Transfusion guidelines were used. The primary outcome was Hct at 36 weeks' PMA. A nonparametric rank sum analysis was performed so that infants who died before 36 weeks and infants who were transfused could be included in an intention-to-treat analysis. Infants were ranked by death (lowest rank) then by number of transfusions (next lowest ranks). For infants who survived and were not transfused, the 36-week PMA Hct was used for the rank.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS:<\/jats:title>\n                  <jats:p>One hundred fifty infants were enrolled (76 iron, 74 controls). There were 2 deaths (1 in each group). One hundred other infants (47 iron, 53 controls) received transfusion(s). There was no significant difference in the primary outcome ranking (P = .59), in the number of transfusions per subject (P = .64), or in 36-week Hct (iron mean \u00b1 SD, 29.2% \u00b1 4.0%; control, 28.3% \u00b1 4.5%; mean difference and 95% confidence interval 0.9 [\u22120.5 to 2.3]; P = .21) or reticulocyte count among survivors. No short-term adverse effects of iron supplementation were observed.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS:<\/jats:title>\n                  <jats:p>Among infants &amp;lt;1500 g birth weight, iron supplementation, in addition to routine iron intake, did not significantly increase the 36-week Hct or the decrease number of transfusions.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1542\/peds.2012-1822","type":"journal-article","created":{"date-parts":[[2013,1,22]],"date-time":"2013-01-22T01:48:41Z","timestamp":1358819321000},"page":"e433-e438","source":"Crossref","is-referenced-by-count":28,"title":["Randomized Trial of Iron Supplementation versus Routine Iron Intake in VLBW Infants"],"prefix":"10.1542","volume":"131","author":[{"given":"Tiffany A.","family":"Taylor","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Division of Neonatal-Perinatal Medicine, The University of Texas Health Science Center at Houston Medical School, Houston, Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathleen A.","family":"Kennedy","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Neonatal-Perinatal Medicine, The University of Texas Health Science Center at Houston Medical School, Houston, Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"417","published-online":{"date-parts":[[2013,2,1]]},"reference":[{"key":"2021120903292267000_B1","first-page":"766","article-title":"Anemia in the newborn infant","volume-title":"Nelson Textbook of Pediatrics","author":"Stoll","year":"2007","edition":"18th ed."},{"issue":"6","key":"2021120903292267000_B2","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1016\/S0022-3476(77)80881-0","article-title":"At what age does iron supplementation become necessary in low-birth-weight infants?","volume":"91","author":"Lundstr\u00f6m","year":"1977","journal-title":"J 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very low birth weight infants\u2014a randomized controlled trial.","volume":"98","author":"Sankar","year":"2009","journal-title":"Acta Paediatr"},{"issue":"4","key":"2021120903292267000_B7","doi-asserted-by":"crossref","DOI":"10.1542\/peds.2009-3624","article-title":"Iron supplements reduce the risk of iron deficiency anemia in marginally low birth weight infants.","volume":"126","author":"Berglund","year":"2010","journal-title":"Pediatrics"},{"issue":"1","key":"2021120903292267000_B8","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1542\/peds.2008-0338","article-title":"Neurodevelopmental outcome of extremely low birth weight infants randomly assigned to restrictive or liberal hemoglobin thresholds for blood transfusion.","volume":"123","author":"Whyte","year":"2009","journal-title":"Pediatrics"},{"issue":"11","key":"2021120903292267000_B9","first-page":"CD000512","article-title":"Low versus high haemoglobin concentration threshold for blood transfusion for preventing morbidity and mortality in very low birth weight infants.","author":"Whyte","year":"2011","journal-title":"Cochrane Database Syst Rev"},{"issue":"1","key":"2021120903292267000_B10","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1007\/s12098-010-0129-7","article-title":"Iron deficiency: beyond anemia.","volume":"78","author":"Yadav","year":"2011","journal-title":"Indian J Pediatr"},{"key":"2021120903292267000_B11","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1186\/1471-2431-12-99","article-title":"Benefits of iron supplementation for low birth weight infants: a systematic review.","volume":"12","author":"Long","year":"2012","journal-title":"BMC Pediatr"},{"issue":"26","key":"2021120903292267000_B12","doi-asserted-by":"crossref","first-page":"1986","DOI":"10.1056\/NEJM199912233412607","article-title":"Disorders of iron metabolism.","volume":"341","author":"Andrews","year":"1999","journal-title":"N Engl J Med"},{"issue":"7","key":"2021120903292267000_B13","doi-asserted-by":"crossref","first-page":"1868","DOI":"10.1093\/jn\/136.7.1868","article-title":"Erythrocyte iron incorporation but not absorption is increased by intravenous iron administration in erythropoietin-treated premature infants.","volume":"136","author":"Widness","year":"2006","journal-title":"J Nutr"}],"container-title":["Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/publications.aap.org\/pediatrics\/article-pdf\/131\/2\/e433\/1089293\/peds_2012-1822.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/publications.aap.org\/pediatrics\/article-pdf\/131\/2\/e433\/1089293\/peds_2012-1822.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,9]],"date-time":"2021-12-09T18:31:52Z","timestamp":1639074712000},"score":1,"resource":{"primary":{"URL":"https:\/\/publications.aap.org\/pediatrics\/article\/131\/2\/e433\/31969\/Randomized-Trial-of-Iron-Supplementation-versus"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,2,1]]},"references-count":13,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2013,2,1]]},"published-print":{"date-parts":[[2013,2,1]]}},"URL":"https:\/\/doi.org\/10.1542\/peds.2012-1822","relation":{},"ISSN":["0031-4005","1098-4275"],"issn-type":[{"value":"0031-4005","type":"print"},{"value":"1098-4275","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,2,1]]}}}