{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T02:51:57Z","timestamp":1778640717253,"version":"3.51.4"},"reference-count":15,"publisher":"American Academy of Pediatrics (AAP)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,5,1]]},"abstract":"\n OBJECTIVE:<\/jats:title>\n Although recent evidence-based guidelines for the management of immune thrombocytopenia (ITP) recommend a conservative, observation-based approach for the majority of patients with newly diagnosed pediatric ITP, current practice patterns are unknown. This study used the Pediatric Health Information System database to examine patterns of inpatient care in newly diagnosed ITP in freestanding US children\u2019s hospitals and to examine geographic differences in care.<\/jats:p>\n <\/jats:sec>\n \n METHODS:<\/jats:title>\n Data were extracted from Pediatric Health Information System for all newly diagnosed ITP admissions aged 1 to 18 years discharged between January 2008 and December 2010. Clinical data obtained included age, gender, length of stay, diagnoses, medications, and discharge status.<\/jats:p>\n <\/jats:sec>\n \n RESULTS:<\/jats:title>\n We identified 2314 unique patients meeting the study diagnosis of newly diagnosed ITP. Noncutaneous bleeding occurred in 12% of patients (intracranial hemorrhage 0.6%), with epistaxis the most commonly reported symptom. Ninety percent of hospitalized patients received ITP-directed therapy, with intravenous immunoglobulin G the most commonly used therapy (78% of patients). We identified significant variation by geographic region in treatment strategies, length of stay, hospital charges, and likelihood of readmission.<\/jats:p>\n <\/jats:sec>\n \n CONCLUSIONS:<\/jats:title>\n A substantial number of children with newly diagnosed ITP continue to be hospitalized and receive intravenous medications, although the majority of these patients do not have clinical bleeding events during the admission. By using these results as a backdrop, future studies will be able to identify if the number of ITP admissions, costs of care, and geographic variability in care decrease with the dissemination and implementation of recently published guidelines.<\/jats:p>\n <\/jats:sec>","DOI":"10.1542\/peds.2012-2021","type":"journal-article","created":{"date-parts":[[2013,4,9]],"date-time":"2013-04-09T00:47:49Z","timestamp":1365468469000},"page":"880-885","source":"Crossref","is-referenced-by-count":31,"title":["Patterns of Inpatient Care for Newly Diagnosed Immune Thrombocytopenia in US Children\u2019s Hospitals"],"prefix":"10.1542","volume":"131","author":[{"given":"Courtney","family":"Kime","sequence":"first","affiliation":[{"name":"College of Medicine, The Ohio State University, Columbus, Ohio;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer","family":"Klima","sequence":"additional","affiliation":[{"name":"Center for Innovation in Pediatric Practice, The Research Institute at Nationwide Children\u2019s Hospital, Columbus, Ohio; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melissa J.","family":"Rose","sequence":"additional","affiliation":[{"name":"Division of Pediatric Hematology\/Oncology, Nationwide Children\u2019s Hospital\/The Ohio State University, Columbus, Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah H.","family":"O\u2019Brien","sequence":"additional","affiliation":[{"name":"Center for Innovation in Pediatric Practice, The Research Institute at Nationwide Children\u2019s Hospital, Columbus, Ohio; and"},{"name":"Division of Pediatric Hematology\/Oncology, Nationwide Children\u2019s Hospital\/The Ohio State University, Columbus, Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"417","published-online":{"date-parts":[[2013,5,1]]},"reference":[{"issue":"9299","key":"2021120900083757100_B1","doi-asserted-by":"crossref","first-page":"2122","DOI":"10.1016\/S0140-6736(01)07219-1","article-title":"Newly diagnosed idiopathic thrombocytopenic purpura in childhood: an observational study.","volume":"358","author":"K\u00fchne","year":"2001","journal-title":"Lancet"},{"issue":"10","key":"2021120900083757100_B2","doi-asserted-by":"crossref","first-page":"4003","DOI":"10.1182\/blood-2008-03-138487","article-title":"Severe hemorrhage in children with newly diagnosed immune thrombocytopenic purpura.","volume":"112","author":"Neunert","year":"2008","journal-title":"Blood"},{"issue":"1","key":"2021120900083757100_B3","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.hoc.2009.11.004","article-title":"Childhood immune thrombocytopenic purpura: diagnosis and management.","volume":"24","author":"Blanchette","year":"2010","journal-title":"Hematol Oncol Clin North Am"},{"issue":"3","key":"2021120900083757100_B4","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1136\/adc.83.3.220","article-title":"Idiopathic thrombocytopenic purpura.","volume":"83","author":"Bolton-Maggs","year":"2000","journal-title":"Arch Dis Child"},{"issue":"2","key":"2021120900083757100_B5","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1182\/blood-2009-06-225565","article-title":"International consensus report on the investigation and management of primary immune thrombocytopenia.","volume":"115","author":"Provan","year":"2010","journal-title":"Blood"},{"issue":"16","key":"2021120900083757100_B6","doi-asserted-by":"crossref","first-page":"4190","DOI":"10.1182\/blood-2010-08-302984","article-title":"The American Society of Hematology 2011 evidence-based practice guideline for immune thrombocytopenia.","volume":"117","author":"Neunert","year":"2011","journal-title":"Blood"},{"issue":"12","key":"2021120900083757100_B7","doi-asserted-by":"crossref","first-page":"1831","DOI":"10.3324\/haematol.2011.050799","article-title":"Newly diagnosed immune thrombocytopenia in children and adults: a comparative prospective observational registry of the Intercontinental Cooperative Immune Thrombocytopenia Study Group.","volume":"96","author":"K\u00fchne","year":"2011","journal-title":"Haematologica"},{"issue":"1","key":"2021120900083757100_B8","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1136\/adc.2010.184234","article-title":"Changing trends in the UK management of childhood ITP.","volume":"97","author":"Grainger","year":"2012","journal-title":"Arch Dis Child"},{"key":"2021120900083757100_B9","doi-asserted-by":"crossref","first-page":"S95","DOI":"10.1007\/s00277-009-0865-9","article-title":"Genetic studies in pediatric ITP: outlook, feasibility, and requirements.","volume":"89","author":"Bergmann","year":"2010","journal-title":"Ann Hematol"},{"issue":"4","key":"2021120900083757100_B10","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1016\/j.hoc.2007.06.007","article-title":"Immune thrombocytopenic purpura.","volume":"21","author":"Psaila","year":"2007","journal-title":"Hematol Oncol Clin North Am"},{"issue":"2","key":"2021120900083757100_B11","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1002\/pbc.20830","article-title":"A cost-utility analysis of treatment for acute childhood idiopathic thrombocytopenic purpura (ITP).","volume":"48","author":"O\u2019Brien","year":"2007","journal-title":"Pediatr Blood Cancer"},{"key":"2021120900083757100_B12"},{"key":"2021120900083757100_B13","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1002\/pds.3241","article-title":"Merging of the National Cancer Institute-funded cooperative oncology group data with an administrative data source to develop a more effective platform for clinical trial analysis and comparative effectiveness research: a report from the Children\u2019s Oncology Group.","volume":"21","author":"Aplenc","year":"2012","journal-title":"Pharmacoepidemiol Drug Saf"},{"issue":"6","key":"2021120900083757100_B14","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1111\/j.1600-0609.2007.00844.x","article-title":"Health-related quality of life measured by the Short Form 36 in immune thrombocytopenic purpura: a cross-sectional survey in China.","volume":"78","author":"Zhou","year":"2007","journal-title":"Eur J Haematol"},{"issue":"1","key":"2021120900083757100_B15","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1097\/MPH.0b013e3182329b4f","article-title":"Analysis of health-related quality of life in children with immune thrombocytopenia and their parents using the Kids\u2019 ITP tools.","volume":"34","author":"Zilber","year":"2012","journal-title":"J Pediatr Hematol Oncol"}],"container-title":["Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/publications.aap.org\/pediatrics\/article-pdf\/131\/5\/880\/1090476\/peds_2012-2021.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/publications.aap.org\/pediatrics\/article-pdf\/131\/5\/880\/1090476\/peds_2012-2021.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,9]],"date-time":"2021-12-09T05:36:09Z","timestamp":1639028169000},"score":1,"resource":{"primary":{"URL":"https:\/\/publications.aap.org\/pediatrics\/article\/131\/5\/880\/31240\/Patterns-of-Inpatient-Care-for-Newly-Diagnosed"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,5,1]]},"references-count":15,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2013,5,1]]},"published-print":{"date-parts":[[2013,5,1]]}},"URL":"https:\/\/doi.org\/10.1542\/peds.2012-2021","relation":{},"ISSN":["0031-4005","1098-4275"],"issn-type":[{"value":"0031-4005","type":"print"},{"value":"1098-4275","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,5,1]]}}}