{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T10:45:25Z","timestamp":1766400325771,"version":"3.40.5"},"reference-count":15,"publisher":"American Academy of Pediatrics (AAP)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,4,1]]},"abstract":"<jats:p>Venous thrombosis can complicate inflammatory bowel diseases, both in adult and pediatric patients, and a few adult cases of thrombotic storm, ie, thrombosis at multiple sites occurring over a period of a few days to a few weeks, have been described. However, venous thrombosis as the first manifestation of an inflammatory bowel disease is extremely rare. We report the case of a 14-year-old girl presenting with ascites and marked hypertransaminasemia resulting from hepatic vein occlusion (Budd-Chiari syndrome). Despite anticoagulant therapy, in the following days she developed criteria suggestive of thrombotic storm to include cerebral vein, right atrial thrombosis, and bilateral pulmonary embolism. Thrombolytic treatment with recombinant-tissue plasminogen activator was started, with resolution of all venous thromboses and without bleeding complications. Additional examinations revealed a severely active ulcerative pancolitis, which did not respond to medical treatment and required surgery. No thrombophilia abnormality nor other risk factors for thrombosis were detected. We conclude that an underlying inflammatory state, such as ulcerative colitis, should be suspected in pediatric patients with venous thrombosis storm.<\/jats:p>","DOI":"10.1542\/peds.2012-2365","type":"journal-article","created":{"date-parts":[[2013,3,5]],"date-time":"2013-03-05T09:09:40Z","timestamp":1362474580000},"page":"e1288-e1291","source":"Crossref","is-referenced-by-count":11,"title":["Thrombotic Storm in a Teenager With Previously Undiagnosed Ulcerative Colitis"],"prefix":"10.1542","volume":"131","author":[{"given":"Umberto","family":"Maggi","sequence":"first","affiliation":[{"name":"General Surgery and Liver Transplantation Unit,"},{"name":"Department of Digestive and Hepatobiliary Surgery, AP-HP, UFR de M\u00e9decine de l'Universit\u00e9 Paris XII-Cr\u00e9teil, Cr\u00e9teil, France; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giorgio","family":"Rossi","sequence":"additional","affiliation":[{"name":"General Surgery and Liver Transplantation Unit, Department of Surgical Sciences,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ettore Contessini","family":"Avesani","sequence":"additional","affiliation":[{"name":"General and Emergency Surgery Unit, and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Artoni","sequence":"additional","affiliation":[{"name":"A Bianchi Bonomi Hemophilia and Thrombosis Center, Department of Internal Medicine and Medical Specialities, and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Flavio","family":"Caprioli","sequence":"additional","affiliation":[{"name":"Gastroenterology Unit 2, Department of Medical, Surgical and Transplant Physiopathology, University of Milan, and Fondazione IRCCS Ca\u2019 Granda, Ospedale Maggiore Policlinico, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luisa","family":"Napolitano","sequence":"additional","affiliation":[{"name":"Pediatric Emergency Unit, Fondazione IRCCS Ca\u2019Granda, Ospedale Maggiore Policlinico, Milan, Italy;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ida","family":"Martinelli","sequence":"additional","affiliation":[{"name":"A Bianchi Bonomi Hemophilia and Thrombosis Center, Department of Internal Medicine and Medical Specialities, and"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"417","published-online":{"date-parts":[[2013,4,1]]},"reference":[{"issue":"6","key":"2021120903060797700_B1","first-page":"503","article-title":"Epidemiology of inflammatory bowel disease in Italy.","volume":"31","author":"Cottone","year":"1999","journal-title":"Ital J Gastroenterol Hepatol"},{"issue":"1","key":"2021120903060797700_B2","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1097\/00005176-200501000-00018","article-title":"Ulcerative colitis complicated by ischemic colitis and Budd Chiari syndrome.","volume":"40","author":"Rahhal","year":"2005","journal-title":"J Pediatr Gastroenterol Nutr"},{"issue":"6","key":"2021120903060797700_B3","doi-asserted-by":"crossref","first-page":"164","DOI":"10.4254\/wjh.v3.i6.164","article-title":"Budd-Chiari syndrome in a patient with ulcerative colitis and no inherited coagulopathy.","volume":"3","author":"Dacha","year":"2011","journal-title":"World J Hepatol"},{"issue":"5","key":"2021120903060797700_B4","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1007\/s10620-006-9503-8","article-title":"Hepatic vein thrombosis as a complication of ulcerative colitis in a 12-year-old patient.","volume":"52","author":"Socha","year":"2007","journal-title":"Dig Dis Sci"},{"issue":"10","key":"2021120903060797700_B5","doi-asserted-by":"crossref","first-page":"2174","DOI":"10.1002\/ibd.21563","article-title":"Thromboembolism in pediatric inflammatory bowel disease: systematic review.","volume":"17","author":"Lazzerini","year":"2011","journal-title":"Inflamm Bowel Dis"},{"issue":"4","key":"2021120903060797700_B6","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/S0002-9343(98)00061-8","article-title":"Thrombotic storm: when thrombosis begets thrombosis.","volume":"104","author":"Kitchens","year":"1998","journal-title":"Am J Med"},{"issue":"4","key":"2021120903060797700_B7","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.amjmed.2010.10.018","article-title":"Thrombotic storm revisited: preliminary diagnostic criteria suggested by the thrombotic storm study group.","volume":"124","author":"Kitchens","year":"2011","journal-title":"Am J Med"},{"issue":"4","key":"2021120903060797700_B8","first-page":"S64","article-title":"Is Hughes-Stovin syndrome Beh\u00e7et\u2019s disease?","volume":"22","author":"Erkan","year":"2004","journal-title":"Clin Exp Rheumatol"},{"key":"2021120903060797700_B9","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1186\/1757-1626-2-98","article-title":"Hughes-Stovin syndrome: a case report and review of the literature.","volume":"2","author":"Chalazonitis","year":"2009","journal-title":"Cases J"},{"key":"2021120903060797700_B10"},{"issue":"7","key":"2021120903060797700_B11","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1097\/00042737-200507000-00001","article-title":"Venous thrombosis in inflammatory bowel disease.","volume":"17","author":"Srirajaskanthan","year":"2005","journal-title":"Eur J Gastroenterol Hepatol"},{"issue":"5","key":"2021120903060797700_B12","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1111\/j.1572-0241.2001.03846.x","article-title":"Unraveling the mechanisms of thrombosis in inflammatory bowel disease.","volume":"96","author":"Koutroubakis","year":"2001","journal-title":"Am J Gastroenterol"},{"issue":"2","key":"2021120903060797700_B13","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1136\/gut.30.2.188","article-title":"Disturbed fibrinolysis in patients with inflammatory bowel disease. A study in blood plasma, colon mucosa, and faeces.","volume":"30","author":"de Jong","year":"1989","journal-title":"Gut"},{"key":"2021120903060797700_B14","first-page":"125","article-title":"Pediatric ulcerative colitis: current treatment approaches including role of infliximab.","volume":"6","author":"Bradley","year":"2012","journal-title":"Biologics"},{"issue":"1","key":"2021120903060797700_B15","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.crohns.2007.11.002","article-title":"European evidence-based Consensus on the management of ulcerative colitis: Current management.","volume":"2","author":"Travis","year":"2008","journal-title":"J Crohn's Colitis"}],"container-title":["Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/publications.aap.org\/pediatrics\/article-pdf\/131\/4\/e1288\/1098816\/peds_2012-2365.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/publications.aap.org\/pediatrics\/article-pdf\/131\/4\/e1288\/1098816\/peds_2012-2365.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,9]],"date-time":"2021-12-09T16:53:27Z","timestamp":1639068807000},"score":1,"resource":{"primary":{"URL":"https:\/\/publications.aap.org\/pediatrics\/article\/131\/4\/e1288\/31783\/Thrombotic-Storm-in-a-Teenager-With-Previously"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,4,1]]},"references-count":15,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2013,4,1]]},"published-print":{"date-parts":[[2013,4,1]]}},"URL":"https:\/\/doi.org\/10.1542\/peds.2012-2365","relation":{},"ISSN":["0031-4005","1098-4275"],"issn-type":[{"type":"print","value":"0031-4005"},{"type":"electronic","value":"1098-4275"}],"subject":[],"published":{"date-parts":[[2013,4,1]]}}}