{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T19:45:47Z","timestamp":1790279147414,"version":"4.1.0"},"reference-count":13,"publisher":"American Academy of Pediatrics (AAP)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,12,1]]},"abstract":"<jats:p>Restricted dietary intake is common among children with behavioral issues. Here we report a case of a severely autistic child who presented initially with limp but who soon developed cough, tachypnea, hypoxia, and tachycardia. An echocardiogram revealed evidence of pulmonary hypertension (PH) with severely dilated right ventricle and elevated right-sided pressures. The etiology of his PH was unclear but further laboratory evaluation demonstrated severe nutritional deficiencies, in particular an undetectable ascorbic acid (vitamin C) level as well as deficient levels of thiamine (vitamin B1), pyridoxine (vitamin B6), cobalamin (vitamin B12), and vitamin D. Repletion of these vitamins was associated with resolution of his PH and his musculoskeletal complaints. We report this case and a review of the relevant literature as a clinical lesson to expand the differential diagnosis of limp in children who may be difficult to assess as well as to report on an unusual association between severe vitamin deficiencies and PH.<\/jats:p>","DOI":"10.1542\/peds.2012-3054","type":"journal-article","created":{"date-parts":[[2013,11,4]],"date-time":"2013-11-04T20:16:41Z","timestamp":1383596201000},"page":"e1699-e1703","source":"Crossref","is-referenced-by-count":58,"title":["Pulmonary Hypertension Associated With Scurvy and Vitamin Deficiencies in an Autistic Child"],"prefix":"10.1542","volume":"132","author":[{"given":"Melody G.","family":"Duvall","sequence":"first","affiliation":[{"name":"Division of Critical Care Medicine, Department of Anesthesia,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yana","family":"Pikman","sequence":"additional","affiliation":[{"name":"Divisions of Hematology and Oncology,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David B.","family":"Kantor","sequence":"additional","affiliation":[{"name":"Division of Critical Care Medicine, Department of Anesthesia,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katelyn","family":"Ariagno","sequence":"additional","affiliation":[{"name":"Gastroenterology and Nutrition, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Summers","sequence":"additional","affiliation":[{"name":"Gastroenterology and Nutrition, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theodore C.","family":"Sectish","sequence":"additional","affiliation":[{"name":"General Pediatrics, Department of Medicine, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary P.","family":"Mullen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Boston Children\u2019s Hospital, Boston, 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Case 23-2007. A 9-year-old boy with bone pain, rash, and gingival hypertrophy.","volume":"357","author":"Duggan","year":"2007","journal-title":"N Engl J Med"}],"container-title":["Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/publications.aap.org\/pediatrics\/article-pdf\/132\/6\/e1699\/909404\/peds_2012-3054.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/publications.aap.org\/pediatrics\/article-pdf\/132\/6\/e1699\/909404\/peds_2012-3054.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,8]],"date-time":"2021-12-08T23:38:25Z","timestamp":1639006705000},"score":1,"resource":{"primary":{"URL":"https:\/\/publications.aap.org\/pediatrics\/article\/132\/6\/e1699\/30557\/Pulmonary-Hypertension-Associated-With-Scurvy-and"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,12,1]]},"references-count":13,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2013,12,1]]},"published-print":{"date-parts":[[2013,12,1]]}},"URL":"https:\/\/doi.org\/10.1542\/peds.2012-3054","relation":{},"ISSN":["0031-4005","1098-4275"],"issn-type":[{"value":"0031-4005","type":"print"},{"value":"1098-4275","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,12,1]]}}}