{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T21:48:48Z","timestamp":1771364928719,"version":"3.50.1"},"reference-count":30,"publisher":"American Academy of Pediatrics (AAP)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,11,1]]},"abstract":"<jats:sec><jats:title>OBJECTIVE:<\/jats:title><jats:p>A previous measles outbreak investigation in a high school in Quebec, Canada identified 2-dose vaccine effectiveness of 94%. The risk of measles in 2-dose recipients was significantly higher (2\u20134 times) when measles vaccine was first administered at 12 versus \u226515 months of age, with no significant effect of the age at second dose. Generalizability of this association was also assessed in the expanded provincial data set of notified cases.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS:<\/jats:title><jats:p>This matched case\u2013control study included only 2-dose recipients. All confirmed (laboratory or epidemiologically linked) cases in patients aged 5 to 17 years were included. Each case was matched to 5 controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS:<\/jats:title><jats:p>A total of 102 cases and 510 controls were included; 89% of cases were in patients 13 to 17 years old. When the first dose was administered at 12 to 13 months compared with \u226515 months of age, the risk of measles in participants outside the outbreak school was 6 times higher (95% confidence interval, 1.33\u201329.3) and was 5.2 times higher (95% confidence interval, 1.91\u201314.3) in the pooled estimate (participants from the outbreak school + outside that school).<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS:<\/jats:title><jats:p>A significantly greater risk of measles among 2-dose recipients whose first dose was given at 12 to 13 months rather than \u226515 months of age is confirmed in the larger Quebec data set. The mechanism remains unknown, but vaccine failures in 2-dose recipients could have substantial implications for measles elimination efforts through 2-dose vaccination. The optimal age at first dose may warrant additional evaluation.<\/jats:p><\/jats:sec>","DOI":"10.1542\/peds.2012-3975","type":"journal-article","created":{"date-parts":[[2013,10,22]],"date-time":"2013-10-22T00:48:33Z","timestamp":1382402913000},"page":"e1126-e1133","source":"Crossref","is-referenced-by-count":29,"title":["Measles in Children Vaccinated With 2 Doses of MMR"],"prefix":"10.1542","volume":"132","author":[{"given":"Fannie","family":"Defay","sequence":"first","affiliation":[{"name":"Unit\u00e9 de Recherche en Sant\u00e9 Publique, CHUQ, Quebec, Canada;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gaston","family":"De Serres","sequence":"additional","affiliation":[{"name":"Unit\u00e9 de Recherche en Sant\u00e9 Publique, CHUQ, Quebec, Canada;"},{"name":"Institut National de Sant\u00e9 Publique du Qu\u00e9bec, Quebec, Canada;"},{"name":"Laval University, Quebec, Canada;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danuta M.","family":"Skowronski","sequence":"additional","affiliation":[{"name":"British Columbia Center for Disease Control, Vancouver, British Columbia, Canada;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicole","family":"Boulianne","sequence":"additional","affiliation":[{"name":"Unit\u00e9 de Recherche en Sant\u00e9 Publique, CHUQ, Quebec, Canada;"},{"name":"Institut National de Sant\u00e9 Publique du Qu\u00e9bec, Quebec, Canada;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manale","family":"Ouakki","sequence":"additional","affiliation":[{"name":"Institut National de Sant\u00e9 Publique du Qu\u00e9bec, Quebec, Canada;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monique","family":"Landry","sequence":"additional","affiliation":[{"name":"Minist\u00e8re de la Sant\u00e9 et des Services Sociaux, Quebec, Canada;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicholas","family":"Brousseau","sequence":"additional","affiliation":[{"name":"Agence de la Sant\u00e9 et des Services Sociaux de la Mauricie et du Centre-du-Qu\u00e9bec, Quebec, Canada; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian J.","family":"Ward","sequence":"additional","affiliation":[{"name":"Research Institute of the McGill University Health Centre, Montr\u00e9al, Quebec, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"417","published-online":{"date-parts":[[2013,11,1]]},"reference":[{"key":"2021120903015572300_B1","first-page":"352","article-title":"Measles vaccine.","volume-title":"Vaccines","author":"Plotkin","year":"2012","edition":"6th ed"},{"issue":"5","key":"2021120903015572300_B2","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1016\/S0022-3476(77)81021-4","article-title":"Persistence of maternal antibody in infants beyond 12 months: mechanism of measles vaccine failure.","volume":"91","author":"Albrecht","year":"1977","journal-title":"J Pediatr"},{"issue":"1","key":"2021120903015572300_B3","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1086\/314847","article-title":"Protection after two doses of measles vaccine is independent of interval between doses.","volume":"180","author":"De Serres","year":"1999","journal-title":"J Infect Dis"},{"key":"2021120903015572300_B4","first-page":"1","article-title":"Measles prevention: recommendations of the Immunization Practices Advisory Committee (ACIP).","volume":"38","author":"CDC","year":"1989","journal-title":"MMWR Recomm Rep"},{"key":"2021120903015572300_B5","unstructured":"National Advisory Committee on Immunization. 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