{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T00:32:43Z","timestamp":1792801963125,"version":"4.5.0"},"reference-count":45,"publisher":"American Academy of Pediatrics (AAP)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,7,1]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND:<\/jats:title>\n                    <jats:p>A novel erythropoiesis stimulating agent (ESA), darbepoetin alfa (Darbe), increases hematocrit in anemic adults when administered every 1 to 3 weeks. Weekly Darbe dosing has not been evaluated in preterm infants. We hypothesized that infants would respond to Darbe by decreasing transfusion needs compared with placebo, with less-frequent dosing than erythropoietin (Epo).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>Preterm infants 500 to 1250 g birth weight and \u226448 hours of age were randomized to Darbe (10 \u03bcg\/kg, 1 time per week subcutaneously), Epo (400 U\/kg, 3 times per week subcutaneously) or placebo (sham dosing) through 35 weeks\u2019 gestation. All received supplemental iron, folate, and vitamin E, and were transfused according to protocol. Transfusions (primary outcome), complete blood counts, absolute reticulocyte counts (ARCs), phlebotomy losses, and adverse events were recorded.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>A total of 102 infants (946 \u00b1 196 g, 27.7 \u00b1 1.8 weeks\u2019 gestation, 51 \u00b1 25 hours of age at first dose) were enrolled. Infants in the Darbe and Epo groups received significantly fewer transfusions (P = .015) and were exposed to fewer donors (P = .044) than the placebo group (Darbe: 1.2 \u00b1 2.4 transfusions and 0.7 \u00b1 1.2 donors per infant; Epo: 1.2 \u00b1 1.6 transfusions and 0.8 \u00b1 1.0 donors per infant; placebo: 2.4 \u00b1 2.9 transfusions and 1.2 \u00b1 1.3 donors per infant). Hematocrit and ARC were higher in the Darbe and Epo groups compared with placebo (P = .001, Darbe and Epo versus placebo for both hematocrit and ARCs). Morbidities were similar among groups, including the incidence of retinopathy of prematurity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>Infants receiving Darbe or Epo received fewer transfusions and fewer donor exposures, and fewer injections were given to Darbe recipients. Darbepoetin and Epo successfully serve as adjuncts to transfusions in maintaining red cell mass in preterm infants.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1542\/peds.2013-0143","type":"journal-article","created":{"date-parts":[[2013,6,18]],"date-time":"2013-06-18T00:50:57Z","timestamp":1371516657000},"page":"e119-e127","source":"Crossref","is-referenced-by-count":94,"title":["A Randomized, Masked, Placebo-Controlled Study of Darbepoetin Alfa in Preterm Infants"],"prefix":"10.1542","volume":"132","author":[{"given":"Robin K.","family":"Ohls","sequence":"first","affiliation":[{"name":"Department of Pediatrics, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert D.","family":"Christensen","sequence":"additional","affiliation":[{"name":"Intermountain Health Care, Salt Lake City, Utah;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beena D.","family":"Kamath-Rayne","sequence":"additional","affiliation":[{"name":"Cincinnati Children\u2019s Hospital, Cincinnati, Ohio;"},{"name":"Department of Pediatrics, University of Colorado, Aurora, Colorado; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam","family":"Rosenberg","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Colorado, Aurora, Colorado; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan E.","family":"Wiedmeier","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Utah, Salt Lake City, Utah"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahshid","family":"Roohi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Conra Backstrom","family":"Lacy","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diane K.","family":"Lambert","sequence":"additional","affiliation":[{"name":"Intermountain Health Care, Salt Lake City, Utah;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jill J.","family":"Burnett","sequence":"additional","affiliation":[{"name":"Intermountain Health Care, Salt Lake City, Utah;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Pruckler","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Colorado, Aurora, Colorado; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ron","family":"Schrader","sequence":"additional","affiliation":[{"name":"Clinical Translational Research Center, University of New Mexico, Albuquerque, New Mexico;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean R.","family":"Lowe","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, 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