{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T23:43:30Z","timestamp":1792107810806,"version":"4.4.0"},"reference-count":30,"publisher":"American Academy of Pediatrics (AAP)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,11,1]]},"abstract":"<jats:sec>\n                  <jats:title>OBJECTIVE:<\/jats:title>\n                  <jats:p>One-dose varicella vaccination for children was introduced in the United States in 1995. In 2006, a second dose was recommended to further decrease varicella disease and outbreaks. We describe the impact of the 2-dose vaccination program on varicella incidence, severity, and outbreaks in 2 varicella active surveillance areas.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS:<\/jats:title>\n                  <jats:p>We examined varicella incidence rates and disease characteristics in Antelope Valley (AV), CA, and West Philadelphia, PA, and varicella outbreak characteristics in AV during 1995\u20132010.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS:<\/jats:title>\n                  <jats:p>In 2010, varicella incidence was 0.3 cases per 1000 population in AV and 0.1 cases per 1000 population in West Philadelphia: 76% and 67% declines, respectively, since 2006 and 98% declines in both sites since 1995; incidence declined in all age groups during 2006\u20132010. From 2006\u20132010, 61.7% of case patients in both surveillance areas had been vaccinated with 1 dose of varicella vaccine and 7.5% with 2 doses. Most vaccinated case patients had &amp;lt;50 lesions with no statistically significant differences among 1- and 2-dose cases (62.8% and 70.3%, respectively). Varicella-related hospitalizations during 2006\u20132010 declined &amp;gt;40% compared with 2002\u20132005 and &amp;gt;85% compared with 1995\u20131998. Twelve varicella outbreaks occurred in AV during 2007\u20132010, compared with 47 during 2003\u20132006 and 236 during 1995\u20131998 (P &amp;lt; .01).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS:<\/jats:title>\n                  <jats:p>Varicella incidence, hospitalizations, and outbreaks in 2 active surveillance areas declined substantially during the first 5 years of the 2-dose varicella vaccination program. Declines in incidence across all ages, including infants who are not eligible for varicella vaccination, and adults, in whom vaccination levels are low, provide evidence of the benefit of high levels of immunity in the population.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1542\/peds.2013-0863","type":"journal-article","created":{"date-parts":[[2013,10,8]],"date-time":"2013-10-08T01:10:17Z","timestamp":1381194617000},"page":"e1134-e1140","source":"Crossref","is-referenced-by-count":109,"title":["Impact of a Routine Two-Dose Varicella Vaccination Program on Varicella Epidemiology"],"prefix":"10.1542","volume":"132","author":[{"given":"Stephanie R.","family":"Bialek","sequence":"first","affiliation":[{"name":"Division of Viral Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dana","family":"Perella","sequence":"additional","affiliation":[{"name":"Philadelphia Department of Public Health, Philadelphia, Pennsylvania; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Zhang","sequence":"additional","affiliation":[{"name":"Division of Viral Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurene","family":"Mascola","sequence":"additional","affiliation":[{"name":"County of Los Angeles Department of Public Health, Los Angeles, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kendra","family":"Viner","sequence":"additional","affiliation":[{"name":"Philadelphia Department of Public Health, Philadelphia, Pennsylvania; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Jackson","sequence":"additional","affiliation":[{"name":"County of Los Angeles Department of Public Health, Los Angeles, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana S.","family":"Lopez","sequence":"additional","affiliation":[{"name":"Division of Viral Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Watson","sequence":"additional","affiliation":[{"name":"Philadelphia Department of Public Health, Philadelphia, Pennsylvania; 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