{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T21:25:17Z","timestamp":1790717117456,"version":"4.1.0"},"reference-count":13,"publisher":"American Academy of Pediatrics (AAP)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,2,1]]},"abstract":"<jats:p>Methylchloroisothiazolinone\/methylisothiazolinone (MCI\/MI) is a combination preservative used in personal care and household products and is a common cause of allergic contact dermatitis (ACD). Recently, MI alone, without MCI, has been increasingly used in consumer products in attempts to minimize allergic reactions. Wet wipes are extensively tested and traditionally believed to be innocuous. MI in wet wipes (\u201cbaby wipes\u201d) has not been previously reported to cause ACD in children in the United States. Only 1 previous report of ACD in a child in Belgium has been recently reported. We report 6 children with chronic, perianal\/buttock, and facial eczematous dermatitis, refractory to multiple topical and oral antibiotics and corticosteroids. All tested positive to MCI\/MI on patch testing. None wore diapers. All patients had been using wet wipes containing MI (without MCI) to affected areas. Discontinuation of wipes resulted in rapid and complete resolution. This is the first report of pediatric ACD to MI in wet wipes in the United States, and the largest series to date. ACD to MI in wet wipes is frequently misdiagnosed as eczema, impetigo, or psoriasis. Wet wipes are increasingly marketed in personal care products for all ages, and MI exposure and sensitization will likely increase. Dermatitis of the perianal, buttock, facial, and hand areas with a history of wet wipe use should raise suspicion of ACD to MI and prompt appropriate patch testing. Rapid resolution occurs after the allergen exposure is eliminated. All isothiozolinones should be avoided in personal care and household products for these patients.<\/jats:p>","DOI":"10.1542\/peds.2013-1453","type":"journal-article","created":{"date-parts":[[2014,1,14]],"date-time":"2014-01-14T02:51:46Z","timestamp":1389667906000},"page":"e434-e438","source":"Crossref","is-referenced-by-count":70,"title":["Six Children With Allergic Contact Dermatitis to Methylisothiazolinone in Wet Wipes (Baby Wipes)"],"prefix":"10.1542","volume":"133","author":[{"given":"Mary Wu","family":"Chang","sequence":"first","affiliation":[{"name":"Departments of Dermatology and Pediatrics, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Radhika","family":"Nakrani","sequence":"additional","affiliation":[{"name":"Medical Student, University of Connecticut School of Medicine, Farmington, Connecticut"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"417","published-online":{"date-parts":[[2014,2,1]]},"reference":[{"issue":"1","key":"2021120900293206600_B1","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1097\/DER.0b013e31827edc73","article-title":"Methylisothiazolinone.","volume":"24","author":"Castanedo-Tardana","year":"2013","journal-title":"Dermatitis"},{"issue":"2","key":"2021120900293206600_B2","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1111\/j.1600-0536.2010.01754.x","article-title":"Methylisothiazolinone, an emerging allergen in cosmetics?","volume":"63","author":"Garcia-Gavin","year":"2010","journal-title":"Contact Dermatitis"},{"issue":"4","key":"2021120900293206600_B3","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1111\/cod.12050","article-title":"Airborne and systemic dermatitis, mimicking atopic dermatitis, caused by methylisothiazolinone in a young child.","volume":"68","author":"Aerts","year":"2013","journal-title":"Contact Dermatitis"},{"key":"2021120900293206600_B4","doi-asserted-by":"crossref","first-page":"S230","DOI":"10.1016\/j.jaad.2005.10.024","article-title":"Contact dermatitis caused by baby wipes.","volume":"54","author":"Fields","year":"2006","journal-title":"J Am Acad Dermatol"},{"issue":"8","key":"2021120900293206600_B5","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1001\/archdermatol.2010.114","article-title":"The hazards of moist toilet paper: allergy to the preservative methylchloroisothiazolinone\/methylisothiazolinone.","volume":"146","author":"Gardner","year":"2010","journal-title":"Arch Dermatol"},{"issue":"4","key":"2021120900293206600_B6","first-page":"189","article-title":"Baby-wipe dermatitis: preservative-induced hand eczema in parents and persons using moist towelettes.","volume":"12","author":"Guin","year":"2001","journal-title":"Am J Contact 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Dermatol"},{"issue":"4","key":"2021120900293206600_B10","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1097\/MOP.0b013e32835585f2","article-title":"Diaper dermatitis: a review and update.","volume":"24","author":"Ravanfar","year":"2012","journal-title":"Curr Opin Pediatr"},{"issue":"3","key":"2021120900293206600_B11","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1111\/j.1525-1470.2009.00934.x","article-title":"The role of allergic contact dermatitis in diaper dermatitis.","volume":"26","author":"Smith","year":"2009","journal-title":"Pediatr Dermatol"},{"issue":"11","key":"2021120900293206600_B12","first-page":"46","article-title":"Frequency of preservative use.","volume":"125","author":"Steinberg","year":"2010","journal-title":"Cosmetics & Toiletries"},{"issue":"2","key":"2021120900293206600_B13","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1097\/DER.0b013e3182819c51","article-title":"North American Contact Dermatitis Group patch test results: 2009 to 2010.","volume":"24","author":"Warshaw","year":"2013","journal-title":"Dermatitis"}],"container-title":["Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/publications.aap.org\/pediatrics\/article-pdf\/133\/2\/e434\/1058961\/peds_2013-1453.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/publications.aap.org\/pediatrics\/article-pdf\/133\/2\/e434\/1058961\/peds_2013-1453.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,9]],"date-time":"2021-12-09T06:22:42Z","timestamp":1639030962000},"score":1,"resource":{"primary":{"URL":"https:\/\/publications.aap.org\/pediatrics\/article\/133\/2\/e434\/30865\/Six-Children-With-Allergic-Contact-Dermatitis-to"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,2,1]]},"references-count":13,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2014,2,1]]},"published-print":{"date-parts":[[2014,2,1]]}},"URL":"https:\/\/doi.org\/10.1542\/peds.2013-1453","relation":{},"ISSN":["0031-4005","1098-4275"],"issn-type":[{"value":"0031-4005","type":"print"},{"value":"1098-4275","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,2,1]]}}}