{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T07:59:23Z","timestamp":1767859163075,"version":"3.49.0"},"reference-count":28,"publisher":"American Academy of Pediatrics (AAP)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,2,1]]},"abstract":"<jats:sec>\n                  <jats:title>OBJECTIVE:<\/jats:title>\n                  <jats:p>Little is known about how very low birth weight (VLBW) affects survival and morbidities among infants with trisomy 13 (T13) or trisomy 18 (T18). We examined the care plans for VLBW infants with T13 or T18 and compared their risks of mortality and neonatal morbidities with VLBW infants with trisomy 21 and VLBW infants without birth defects.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS:<\/jats:title>\n                  <jats:p>Infants with birth weight 401 to 1500 g born or cared for at a participating center of the Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network during the period 1994\u20132009 were studied. Poisson regression models were used to examine risk of death and neonatal morbidities among infants with T13 or T18.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS:<\/jats:title>\n                  <jats:p>Of 52\u2009262 VLBW infants, 38 (0.07%) had T13 and 128 (0.24%) had T18. Intensity of care in the delivery room varied depending on whether the trisomy was diagnosed before or after birth. The plan for subsequent care for the majority of the infants was to withdraw care or to provide comfort care. Eleven percent of infants with T13 and 9% of infants with T18 survived to hospital discharge. Survivors with T13 or T18 had significantly increased risk of patent ductus arteriosus and respiratory distress syndrome compared with infants without birth defects. No infant with T13 or T18 developed necrotizing enterocolitis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS:<\/jats:title>\n                  <jats:p>In this cohort of liveborn VLBW infants with T13 or T18, the timing of trisomy diagnosis affected the plan for care, survival was poor, and death usually occurred early.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1542\/peds.2013-1702","type":"journal-article","created":{"date-parts":[[2014,1,21]],"date-time":"2014-01-21T02:09:09Z","timestamp":1390270149000},"page":"226-235","source":"Crossref","is-referenced-by-count":48,"title":["Mortality and Morbidity of VLBW Infants With Trisomy 13 or Trisomy 18"],"prefix":"10.1542","volume":"133","author":[{"given":"Nansi S.","family":"Boghossian","sequence":"first","affiliation":[{"name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, Maryland;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nellie I.","family":"Hansen","sequence":"additional","affiliation":[{"name":"Social, Statistical and Environmental Sciences Unit, RTI International, Research Triangle Park, North Carolina;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edward F.","family":"Bell","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Iowa, Iowa City, Iowa;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara J.","family":"Stoll","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Emory University School of Medicine and Children\u2019s Healthcare of Atlanta, Atlanta, Georgia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey C.","family":"Murray","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Iowa, Iowa City, Iowa;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John C.","family":"Carey","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Utah, Salt Lake City, Utah;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ira","family":"Adams-Chapman","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Emory University School of Medicine and Children\u2019s Healthcare of Atlanta, Atlanta, Georgia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seetha","family":"Shankaran","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Wayne State University, Detroit, Michigan;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michele C.","family":"Walsh","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Case Western Reserve University and Rainbow Babies & Children\u2019s Hospital, Cleveland, Ohio;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abbot R.","family":"Laptook","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Brown University and Women & Infants Hospital of Rhode Island, Providence, Rhode Island;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roger G.","family":"Faix","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Utah, Salt Lake City, Utah;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nancy S.","family":"Newman","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Case Western Reserve University and Rainbow Babies & Children\u2019s Hospital, Cleveland, Ohio;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ellen C.","family":"Hale","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Emory University School of Medicine and Children\u2019s Healthcare of Atlanta, Atlanta, Georgia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abhik","family":"Das","sequence":"additional","affiliation":[{"name":"Social, Statistical and Environmental Sciences Unit, RTI International, Rockville, Maryland;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leslie D.","family":"Wilson","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angelita M.","family":"Hensman","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Brown University and Women & Infants Hospital of Rhode Island, Providence, Rhode Island;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cathy","family":"Grisby","sequence":"additional","affiliation":[{"name":"Perinatal Institute, Cincinnati Children\u2019s Hospital Medical Center, Cincinnati, Ohio;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monica V.","family":"Collins","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Alabama at Birmingham, Birmingham, Alabama;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diana M.","family":"Vasil","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joanne","family":"Finkle","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Duke University, Durham, North Carolina;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deanna","family":"Maffett","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Rochester School of Medicine and Dentistry, Rochester, New York;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. 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