{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T15:14:28Z","timestamp":1793373268660,"version":"4.5.0"},"reference-count":19,"publisher":"American Academy of Pediatrics (AAP)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,3,1]]},"abstract":"<jats:sec>\n                  <jats:title>BACKGROUND AND OBJECTIVE:<\/jats:title>\n                  <jats:p>Dexamethasone has been proposed as an equivalent therapy to prednisone\/prednisolone for acute asthma exacerbations in pediatric patients. Although multiple small trials exist, clear consensus data are lacking. This systematic review and meta-analysis aimed to determine whether intramuscular or oral dexamethasone is equivalent or superior to a 5-day course of oral prednisone or prednisolone. The primary outcome of interest was return visits or hospital readmissions.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS:<\/jats:title>\n                  <jats:p>A search of PubMed (Medline) through October 19, 2013, by using the keywords dexamethasone or decadron and asthma or status asthmaticus identified potential studies. Six randomized controlled trials in the emergency department of children \u226418 years of age comparing dexamethasone with prednisone\/prednisolone for the treatment of acute asthma exacerbations were included. Data were abstracted by 4 authors and verified by a second author. Two reviewers evaluated study quality independently and interrater agreement was assessed.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS:<\/jats:title>\n                  <jats:p>There was no difference in relative risk (RR) of relapse between the 2 groups at any time point (5 days RR 0.90, 95% confidence interval [CI] 0.46\u20131.78, Q = 1.86, df = 3, I2 = 0.0%, 10\u201314 days RR 1.14, 95% CI 0.77\u20131.67, Q = 0.84, df = 2, I2 = 0.0%, or 30 days RR 1.20, 95% CI 0.03\u201356.93). Patients who received dexamethasone were less likely to experience vomiting in either the emergency department (RR 0.29, 95% CI 0.12\u20130.69, Q = 3.78, df = 3, I2 = 20.7%) or at home (RR 0.32, 95% CI 0.14\u20130.74, Q = 2.09, df = 2, I2 = 4.2%).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS:<\/jats:title>\n                  <jats:p>Practitioners should consider single or 2-dose regimens of dexamethasone as a viable alternative to a 5-day course of prednisone\/prednisolone.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1542\/peds.2013-2273","type":"journal-article","created":{"date-parts":[[2014,2,11]],"date-time":"2014-02-11T02:11:16Z","timestamp":1392084676000},"page":"493-499","source":"Crossref","is-referenced-by-count":106,"title":["Dexamethasone for Acute Asthma Exacerbations in Children: A Meta-analysis"],"prefix":"10.1542","volume":"133","author":[{"given":"Grant E.","family":"Keeney","sequence":"first","affiliation":[{"name":"Departments of Pediatrics, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew P.","family":"Gray","sequence":"additional","affiliation":[{"name":"Departments of Pediatrics, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea K.","family":"Morrison","sequence":"additional","affiliation":[{"name":"Departments of Pediatrics, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael N.","family":"Levas","sequence":"additional","affiliation":[{"name":"Departments of Pediatrics, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth A.","family":"Kessler","sequence":"additional","affiliation":[{"name":"Departments of Pediatrics, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Garick D.","family":"Hill","sequence":"additional","affiliation":[{"name":"Departments of Pediatrics, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc H.","family":"Gorelick","sequence":"additional","affiliation":[{"name":"Departments of Pediatrics, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey L.","family":"Jackson","sequence":"additional","affiliation":[{"name":"General Internal Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin; and"},{"name":"Zablocki VAMC, Milwaukee, Wisconsin"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"417","published-online":{"date-parts":[[2014,3,1]]},"reference":[{"key":"2021120903505507600_B1","doi-asserted-by":"crossref","first-page":"S94","DOI":"10.1016\/j.jaci.2007.09.029","article-title":"Expert panel report 3 (EPR-3): Guidelines for the diagnosis and management of asthma-summary report 2007.","volume":"120","author":"National Asthma Education and Prevention Program","year":"2007","journal-title":"J Allergy Clin Immunol"},{"issue":"5","key":"2021120903505507600_B2","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1097\/01.pec.0000092585.40174.f6","article-title":"Corticosteroids in acute asthma: past, present, and future.","volume":"19","author":"Scarfone","year":"2003","journal-title":"Pediatr Emerg Care"},{"key":"2021120903505507600_B3","doi-asserted-by":"crossref","first-page":"S131","DOI":"10.1542\/peds.2008-2233C","article-title":"Status of childhood asthma in the United States, 1980\u20132007.","volume":"123","author":"Akinbami","year":"2009","journal-title":"Pediatrics"},{"issue":"8","key":"2021120903505507600_B4","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1111\/j.1398-9995.2012.02865.x","article-title":"International consensus on (ICON) pediatric asthma.","volume":"67","author":"Papadopoulos","year":"2012","journal-title":"Allergy"},{"key":"2021120903505507600_B5","unstructured":"Higgins J, Altman D, Sterne A. 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