{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T23:02:50Z","timestamp":1769641370729,"version":"3.49.0"},"reference-count":6,"publisher":"American Academy of Pediatrics (AAP)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,9,1]]},"abstract":"<jats:p>Low-molecular-weight heparins, such as enoxaparin, are often used to treat thrombosis in infants. We present 4 infants with diffuse brain injury who developed cerebral venous sinus thrombosis or deep vein thrombosis and were treated with enoxaparin. These infants subsequently developed subdural hemorrhages, and enoxaparin was stopped. In 3 cases, the subdural hemorrhages were found on routine surveillance brain MRI, and in 1 case imaging was urgently obtained because of focal seizures. Two patients needed urgent neurosurgical intervention, and all subdural hemorrhages improved or resolved on follow-up imaging. Each infant developed severe neurologic deficits, probably from the coexisting diffuse brain injury rather than from the subdural hemorrhages themselves. The risk of intracranial hemorrhage from enoxaparin may be accentuated in patients with diffuse brain injury, and careful consideration should be given before treatment in this population.<\/jats:p>","DOI":"10.1542\/peds.2013-3029","type":"journal-article","created":{"date-parts":[[2014,8,12]],"date-time":"2014-08-12T04:32:35Z","timestamp":1407817955000},"page":"e889-e893","source":"Crossref","is-referenced-by-count":7,"title":["Subdural Hemorrhages Associated With Antithrombotic Therapy in Infants With Cerebral Atrophy"],"prefix":"10.1542","volume":"134","author":[{"given":"Louis T.","family":"Dang","sequence":"first","affiliation":[{"name":"Divisions of Pediatric Neurology,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jordan A.","family":"Shavit","sequence":"additional","affiliation":[{"name":"Pediatric Hematology\/Oncology, and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rani K.","family":"Singh","sequence":"additional","affiliation":[{"name":"Divisions of Pediatric Neurology,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sucheta M.","family":"Joshi","sequence":"additional","affiliation":[{"name":"Divisions of Pediatric Neurology,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven M.","family":"Leber","sequence":"additional","affiliation":[{"name":"Divisions of Pediatric Neurology,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John D.E.","family":"Barks","sequence":"additional","affiliation":[{"name":"Neonatology, Department of Pediatrics and Communicable Diseases, C.S. Mott Children\u2019s Hospital, University of Michigan, Ann Arbor, Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ren\u00e9e A.","family":"Shellhaas","sequence":"additional","affiliation":[{"name":"Divisions of Pediatric Neurology,"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"417","published-online":{"date-parts":[[2014,9,1]]},"reference":[{"key":"2021120908524212500_B1","first-page":"e737S","article-title":"Antithrombotic therapy in neonates and children: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines","volume-title":"Chest","author":"Monagle","year":"2012"},{"issue":"5","key":"2021120908524212500_B2","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1016\/j.jpeds.2009.11.061","article-title":"Antithrombotic treatment in neonatal cerebral sinovenous thrombosis: results of the International Pediatric Stroke Study","volume":"156","author":"Jordan","year":"2010","journal-title":"J Pediatr"},{"issue":"5","key":"2021120908524212500_B3","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1002\/ana.21936","article-title":"Anticoagulants in pediatric cerebral sinovenous thrombosis: a safety and outcome study.","volume":"67","author":"Moharir","year":"2010","journal-title":"Ann Neurol"},{"issue":"3","key":"2021120908524212500_B4","doi-asserted-by":"crossref","DOI":"10.1542\/peds.2010-1035","article-title":"Neonatal cerebral sinovenous thrombosis: sifting the evidence for a diagnostic plan and treatment strategy.","volume":"126","author":"Yang","year":"2010","journal-title":"Pediatrics"},{"issue":"4","key":"2021120908524212500_B5","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1159\/000055951","article-title":"A theoretical model of benign external hydrocephalus that predicts a predisposition towards extra-axial hemorrhage after minor head trauma.","volume":"33","author":"Papasian","year":"2000","journal-title":"Pediatr Neurosurg"},{"issue":"10","key":"2021120908524212500_B6","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1177\/0009922811406435","article-title":"Subdural hematoma in infants without accidental or nonaccidental injury: benign external hydrocephalus, a risk factor.","volume":"50","author":"Ghosh","year":"2011","journal-title":"Clin Pediatr (Phila)"}],"container-title":["Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/publications.aap.org\/pediatrics\/article-pdf\/134\/3\/e889\/900391\/peds_2013-3029.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/publications.aap.org\/pediatrics\/article-pdf\/134\/3\/e889\/900391\/peds_2013-3029.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T05:57:14Z","timestamp":1717221434000},"score":1,"resource":{"primary":{"URL":"https:\/\/publications.aap.org\/pediatrics\/article\/134\/3\/e889\/74171\/Subdural-Hemorrhages-Associated-With"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,9,1]]},"references-count":6,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2014,9,1]]},"published-print":{"date-parts":[[2014,9,1]]}},"URL":"https:\/\/doi.org\/10.1542\/peds.2013-3029","relation":{},"ISSN":["0031-4005","1098-4275"],"issn-type":[{"value":"0031-4005","type":"print"},{"value":"1098-4275","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,9,1]]}}}