{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T03:19:53Z","timestamp":1792466393592,"version":"4.5.0"},"reference-count":20,"publisher":"American Academy of Pediatrics (AAP)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,6,1]]},"abstract":"\n OBJECTIVE:<\/jats:title>\n Caustic substance ingestion in childhood is a public health issue in developing countries, and several management protocols have been proposed to prevent the resulting esophageal strictures. The role of corticosteroids in preventing corrosive-induced strictures is controversial. Our aim was to study the influence of high doses of corticosteroids in preventing esophageal strictures.<\/jats:p>\n <\/jats:sec>\n \n METHODS:<\/jats:title>\n Eighty-three children with a mean age of 4.10 \u00b1 2.63 years and with grade IIb esophageal burns (an esophagogastroscopy was performed within 24\u201348 hours of injury) due to corrosive substance ingestion were enrolled in our study between 2005 and 2008. Forty-two children (study group) received methylprednisolone (1 g\/1.73 m2 per day for 3 days), ranitidine, ceftriaxone, and total parenteral nutrition. Forty-one children (control group) were administered the same regimen excluding methylprednisolone. Stricture development was compared between groups based on endoscopic and radiologic findings.<\/jats:p>\n <\/jats:sec>\n \n RESULTS:<\/jats:title>\n During the endoscopic examination, stricture development was observed in 4 patients (10.8%) in the study group and in 12 patients (30%) in the control group. The difference was statistically significant (P = .038). The stricture development rate in the upper gastrointestinal system with barium meal was 14.3% and 45.0% in the study and control groups, respectively. The difference was statistically significant (P = .004). The duration of total parenteral nutrition was shorter in the study group compared with the control group (P = .001). High doses of methylprednisolone were well tolerated in the study group without any side effects.<\/jats:p>\n <\/jats:sec>\n \n CONCLUSIONS:<\/jats:title>\n High doses of methylprednisolone used for the management of grade IIb esophageal burns may reduce stricture development.<\/jats:p>\n <\/jats:sec>","DOI":"10.1542\/peds.2013-3331","type":"journal-article","created":{"date-parts":[[2014,5,27]],"date-time":"2014-05-27T01:34:37Z","timestamp":1401154477000},"page":"e1518-e1524","source":"Crossref","is-referenced-by-count":81,"title":["High Doses of Methylprednisolone in the Management of Caustic Esophageal Burns"],"prefix":"10.1542","volume":"133","author":[{"given":"Merve","family":"Usta","sequence":"first","affiliation":[{"name":"Department of Pediatric Gastroenterology, Hepatology and Nutrition, Sisli Etfal Education and Research Hospital, Istanbul, Turkey;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T\u00fclay","family":"Erkan","sequence":"additional","affiliation":[{"name":"Department of Pediatric Gastroenterology, Hepatology and Nutrition, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fugen Cullu","family":"Cokugras","sequence":"additional","affiliation":[{"name":"Department of Pediatric Gastroenterology, Hepatology and Nutrition, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nafiye","family":"Urganci","sequence":"additional","affiliation":[{"name":"Department of Pediatric Gastroenterology, Hepatology and Nutrition, Sisli Etfal Education and Research Hospital, Istanbul, Turkey;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zerrin","family":"Onal","sequence":"additional","affiliation":[{"name":"Department of Pediatric Gastroenterology, Hepatology and Nutrition, Bakirkoy Dr. Sadi Konuk Education and Research Hospital, Istanbul, Turkey; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahir","family":"Gulcan","sequence":"additional","affiliation":[{"name":"Department of Pediatric Gastroenterology, Hepatology and Nutrition, Acibadem University Medical Faculty, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tufan","family":"Kutlu","sequence":"additional","affiliation":[{"name":"Department of Pediatric Gastroenterology, Hepatology and Nutrition, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"417","published-online":{"date-parts":[[2014,6,1]]},"reference":[{"issue":"3","key":"2021121022223262800_B1","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1007\/s00383-004-1153-3","article-title":"Corrosive esophagitis in children.","volume":"20","author":"Huang","year":"2004","journal-title":"Pediatr Surg Int"},{"issue":"2","key":"2021121022223262800_B2","doi-asserted-by":"crossref","first-page":"125","DOI":"10.2165\/00139709-200524020-00006","article-title":"Do corticosteroids prevent oesophageal stricture after corrosive ingestion?","volume":"24","author":"Pelclov\u00e1","year":"2005","journal-title":"Toxicol Rev"},{"issue":"6","key":"2021121022223262800_B3","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/S0929-693X(97)87571-9","article-title":"Severity of ingestion of caustic substance in children [in French].","volume":"4","author":"Lamireau","year":"1997","journal-title":"Arch Pediatr"},{"issue":"5","key":"2021121022223262800_B4","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1007\/s004310050627","article-title":"A retrospective analysis of ingestion of caustic substances by children. Ten-year statistics in Galicia.","volume":"156","author":"Bautista Casasnovas","year":"1997","journal-title":"Eur J Pediatr"},{"key":"2021121022223262800_B5","first-page":"97","article-title":"Treatment of esophageal caustic injuries: experience with high-dose dexamethasone.","volume":"8(2)","author":"Cadranel","year":"1993","journal-title":"Pediatr Surg Int"},{"issue":"5","key":"2021121022223262800_B6","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1016\/0022-3468(71)90382-4","article-title":"Pathophysiology and management of acute corrosive burns of the esophagus: results of treatment in 285 children.","volume":"6","author":"Haller","year":"1971","journal-title":"J Pediatr Surg"},{"key":"2021121022223262800_B7","first-page":"710","article-title":"The effect of cortisone on the formation of granulation tissue in mice","volume":"26","author":"Spain","year":"1950","journal-title":"Am J Pathol"},{"issue":"10","key":"2021121022223262800_B8","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1056\/NEJM199009063231004","article-title":"A controlled trial of corticosteroids in children with corrosive injury of the esophagus.","volume":"323","author":"Anderson","year":"1990","journal-title":"N Engl J Med"},{"issue":"5","key":"2021121022223262800_B9","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/0735-6757(92)90067-8","article-title":"Steroids for the treatment of corrosive esophageal injury: a statistical analysis of past studies.","volume":"10","author":"Howell","year":"1992","journal-title":"Am J Emerg Med"},{"key":"2021121022223262800_B10","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1097\/00005176-200505000-00133","article-title":"The effect of steroid therapy on severe corrosive oesophageal burns in children: a multicenteric prospective study [abstract].","volume":"40","author":"Do\u011fan","year":"2005","journal-title":"J Pediatr Gastroenterol Nutr"},{"issue":"1","key":"2021121022223262800_B11","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.arcped.2003.10.011","article-title":"High doses of steroids in the management of caustic esophageal burns in children [in French].","volume":"11","author":"Boukthir","year":"2004","journal-title":"Arch Pediatr"},{"issue":"5","key":"2021121022223262800_B12","first-page":"411","article-title":"Accidental caustic ingestion in Tunisian child. 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