{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T02:46:47Z","timestamp":1791859607216,"version":"4.3.4"},"reference-count":16,"publisher":"American Academy of Pediatrics (AAP)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,10,1]]},"abstract":"<jats:p>Neonatal severe primary hyperparathyroidism presents in the first days of life with severe life-threatening hypercalcemia. It is associated with an inactivating homozygous mutation of the calcium sensing receptor gene. Total parathyroidectomy is the treatment of choice, so the surgeon must identify all the parathyroid tissue, including supernumerary and ectopic glands. We present the case of an infant who underwent total parathyroidectomy at age 4 months in which intraoperative parathyroid hormone monitoring provided immediate confirmation of surgical cure.<\/jats:p>","DOI":"10.1542\/peds.2013-3668","type":"journal-article","created":{"date-parts":[[2014,9,2]],"date-time":"2014-09-02T00:42:32Z","timestamp":1409618552000},"page":"e1203-e1205","source":"Crossref","is-referenced-by-count":13,"title":["Intraoperative Parathyroid Hormone Monitoring in Neonatal Severe Primary Hyperparathyroidism"],"prefix":"10.1542","volume":"134","author":[{"given":"Emilio","family":"Garc\u00eda-Garc\u00eda","sequence":"first","affiliation":[{"name":"Virgen del Roc\u00edo Hospital, Sevilla, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inmaculada","family":"Dom\u00ednguez-Pascual","sequence":"additional","affiliation":[{"name":"Virgen del Roc\u00edo Hospital, Sevilla, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mercedes","family":"Requena-D\u00edaz","sequence":"additional","affiliation":[{"name":"Virgen del Roc\u00edo Hospital, Sevilla, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa","family":"Cabello-Laureano","sequence":"additional","affiliation":[{"name":"Virgen del Roc\u00edo Hospital, Sevilla, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Israel","family":"Fern\u00e1ndez-Pineda","sequence":"additional","affiliation":[{"name":"Virgen del Roc\u00edo Hospital, Sevilla, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda J.","family":"S\u00e1nchez-Mart\u00edn","sequence":"additional","affiliation":[{"name":"Virgen del Roc\u00edo Hospital, Sevilla, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"417","published-online":{"date-parts":[[2014,10,1]]},"reference":[{"issue":"5","key":"2021120903422681900_B1","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1007\/s00431-010-1335-z","article-title":"Neonatal severe hyperparathyroidism: further clinical and molecular delineation.","volume":"170","author":"Al-Khalaf","year":"2011","journal-title":"Eur J Pediatr"},{"issue":"6","key":"2021120903422681900_B2","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/S0022-3468(86)80219-6","article-title":"Primary hyperparathyroidism in infancy.","volume":"21","author":"Ross","year":"1986","journal-title":"J Pediatr Surg"},{"issue":"9","key":"2021120903422681900_B3","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.jcma.2012.06.012","article-title":"Primary hyperparathyroidism in children and adolescents.","volume":"75","author":"Roizen","year":"2012","journal-title":"J Chin Med Assoc"},{"issue":"5","key":"2021120903422681900_B4","doi-asserted-by":"crossref","DOI":"10.1542\/peds.2006-3209","article-title":"Neonatal hyperparathyroidism and pamidronate therapy in an extremely premature infant.","volume":"120","author":"Fox","year":"2007","journal-title":"Pediatrics"},{"issue":"3","key":"2021120903422681900_B5","doi-asserted-by":"crossref","DOI":"10.1542\/peds.2011-0128","article-title":"Successful use of bisphosphonate and calcimimetic in neonatal severe primary hyperparathyroidism.","volume":"129","author":"Wilhelm-Bals","year":"2012","journal-title":"Pediatrics"},{"issue":"3","key":"2021120903422681900_B6","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1530\/acta.0.1050350","article-title":"Post-parathyroidectomy restoration of normal calcium homeostasis in neonatal primary hyperparathyroidism.","volume":"105","author":"Ch\u2019ng","year":"1984","journal-title":"Acta Endocrinol (Copenh)"},{"issue":"2","key":"2021120903422681900_B7","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S0039-6060(03)00387-8","article-title":"Comparison of parathyroid hormone levels from the intact and whole parathyroid hormone assays after parathyroidectomy for primary and secondary hyperparathyroidism.","volume":"135","author":"Yamashita","year":"2004","journal-title":"Surgery"},{"issue":"4","key":"2021120903422681900_B8","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1016\/j.jpedsurg.2009.08.005","article-title":"Surgical management of severe neonatal hyperparathyroidism: one center\u2019s experience.","volume":"45","author":"Al-Shanafey","year":"2010","journal-title":"J Pediatr Surg"},{"issue":"5","key":"2021120903422681900_B9","first-page":"933","article-title":"Severe primary hyperparathyroidism in a neonate having a parent with hypercalcemia: treatment by total parathyroidectomy and simultaneous heterotopic autotransplantation.","volume":"108","author":"Fujimoto","year":"1990","journal-title":"Surgery"},{"issue":"2","key":"2021120903422681900_B10","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1542\/peds.78.2.263","article-title":"Severe primary hyperparathyroidism in a neonate with two hypercalcemic parents: management with parathyroidectomy and heterotopic autotransplantation.","volume":"78","author":"Cooper","year":"1986","journal-title":"Pediatrics"},{"issue":"1","key":"2021120903422681900_B11","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1111\/j.1651-2227.1986.tb10179.x","article-title":"Neonatal primary hyperparathyroidism: total parathyroidectomy with autotransplantation of cryopreserved parathyroid tissue.","volume":"75","author":"Lutz","year":"1986","journal-title":"Acta Paediatr Scand"},{"issue":"5","key":"2021120903422681900_B12","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1007\/s00431-008-0794-y","article-title":"Unusually severe phenotype of neonatal primary hyperparathyroidism due to a heterozygous inactivating mutation in the CASR gene.","volume":"168","author":"Obermannova","year":"2009","journal-title":"Eur J Pediatr"},{"issue":"9","key":"2021120903422681900_B13","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1007\/s00247-002-0737-0","article-title":"Neonatal, severe primary hyperparathyroidism: a 7-year clinical and radiological follow-up of one patient.","volume":"32","author":"Doria","year":"2002","journal-title":"Pediatr Radiol"},{"issue":"3","key":"2021120903422681900_B14","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/S0022-3468(96)90756-3","article-title":"Primary hyperparathyroidism in infancy: a case report.","volume":"31","author":"Cakmak","year":"1996","journal-title":"J Pediatr Surg"},{"issue":"8","key":"2021120903422681900_B15","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1515\/jpem-2001-0818","article-title":"Primary hyperparathyroidism in an infant with three parathyroid glands and pulmonary calcinosis.","volume":"14","author":"Topaloglu","year":"2001","journal-title":"J Pediatr Endocrinol Metab"},{"issue":"10","key":"2021120903422681900_B16","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1053\/jpsu.2000.16430","article-title":"Intrathyroid parathyroid gland and neonatal primary hyperparathyroidism.","volume":"35","author":"Janik","year":"2000","journal-title":"J Pediatr Surg"}],"container-title":["Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/publications.aap.org\/pediatrics\/article-pdf\/134\/4\/e1203\/1098922\/peds_2013-3668.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/publications.aap.org\/pediatrics\/article-pdf\/134\/4\/e1203\/1098922\/peds_2013-3668.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,16]],"date-time":"2022-04-16T02:34:29Z","timestamp":1650076469000},"score":1,"resource":{"primary":{"URL":"https:\/\/publications.aap.org\/pediatrics\/article\/134\/4\/e1203\/32915\/Intraoperative-Parathyroid-Hormone-Monitoring-in"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,10,1]]},"references-count":16,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2014,10,1]]},"published-print":{"date-parts":[[2014,10,1]]}},"URL":"https:\/\/doi.org\/10.1542\/peds.2013-3668","relation":{},"ISSN":["0031-4005","1098-4275"],"issn-type":[{"value":"0031-4005","type":"print"},{"value":"1098-4275","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,10,1]]}}}