{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T18:04:28Z","timestamp":1788458668274,"version":"build-2803163510"},"reference-count":28,"publisher":"American Academy of Pediatrics (AAP)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,7,1]]},"abstract":"<jats:sec><jats:title>BACKGROUND:<\/jats:title><jats:p>When varicella vaccine was licensed in the United States in 1995, there were concerns that childhood vaccination might increase the number of adolescents susceptible to varicella and shift disease toward older age groups where it can be more severe.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS:<\/jats:title><jats:p>We conducted a series of 5 cross-sectional studies in 1994 to 1995 (prevaccine), 2000, 2003, 2006, and 2009 in Kaiser Permanente of Northern California to assess changes in varicella epidemiology in children and adolescents, as well as changes in varicella hospitalization in people of all ages. For each study, information on varicella history and varicella occurrence during the past year was obtained by telephone survey from a sample of \u223c8000 members 5 to 19 years old; varicella hospitalization rates were calculated for the entire membership.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS:<\/jats:title><jats:p>Between 1995 and 2009, the overall incidence of varicella in 5- to 19-year-olds decreased from 25.8 to 1.3 per 1000 person-years, a \u223c90% to 95% decline in the various age categories (5\u20139, 10\u201314, and 15\u201319 years of age). The proportion of varicella-susceptible children and adolescents also decreased in all age groups, including in 15- to 19-year-olds (from 15.6% in 1995 to 7.6% in 2009). From 1994 to 2009, age-adjusted varicella hospitalization rates in the general member population decreased from 2.13 to 0.25 per 100\u2009000, a \u223c90% decline.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS:<\/jats:title><jats:p>In the 15 years after the introduction of varicella vaccine, a major reduction in varicella incidence and hospitalization was observed with no evidence of a shift in the burden of varicella to older age groups.<\/jats:p><\/jats:sec>","DOI":"10.1542\/peds.2013-4251","type":"journal-article","created":{"date-parts":[[2014,6,10]],"date-time":"2014-06-10T03:53:17Z","timestamp":1402372397000},"page":"24-30","source":"Crossref","is-referenced-by-count":69,"title":["Impact of Vaccination on the Epidemiology of Varicella: 1995\u20132009"],"prefix":"10.1542","volume":"134","author":[{"given":"Roger","family":"Baxter","sequence":"first","affiliation":[{"name":"Kaiser Permanente Vaccine Study Center, Oakland, California;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trung N.","family":"Tran","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Merck Sharp & Dohme Corp, Whitehouse Station, New Jersey;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula","family":"Ray","sequence":"additional","affiliation":[{"name":"Kaiser Permanente Vaccine Study Center, Oakland, California;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edwin","family":"Lewis","sequence":"additional","affiliation":[{"name":"Kaiser Permanente Vaccine Study Center, Oakland, California;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce","family":"Fireman","sequence":"additional","affiliation":[{"name":"Kaiser Permanente Vaccine Study Center, Oakland, California;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steve","family":"Black","sequence":"additional","affiliation":[{"name":"Center for Global Health, Cincinnati Children\u2019s Hospital, Cincinnati, Ohio; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henry R.","family":"Shinefield","sequence":"additional","affiliation":[{"name":"University of California San Francisco Medical Center, San Francisco, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul M.","family":"Coplan","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Merck Sharp & Dohme Corp, Whitehouse Station, New Jersey;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Saddier","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Merck Sharp & Dohme Corp, Whitehouse Station, New 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