{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T02:28:46Z","timestamp":1785551326112,"version":"3.56.0"},"reference-count":50,"publisher":"American Academy of Pediatrics (AAP)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,11,1]]},"abstract":"<jats:sec>\n                  <jats:title>BACKGROUND AND OBJECTIVE:<\/jats:title>\n                  <jats:p>No consensus has yet been reached with regard to the link between otitis media with effusion (OME), hearing loss, and language development in children with cleft palate. The objective of this study was to address the effectiveness of ventilation tube insertion (VTI) for OME in children with cleft palate.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS:<\/jats:title>\n                  <jats:p>A dual review process was used to assess eligible studies drawn from PubMed, Medline via Ovid, Cumulative Index to Nursing and Allied Health Literature, Cochrane Library, and reference lists between 1948 and November 2013. Potentially relevant papers were selected according to the full text of the articles. Relevant data were extracted onto a data extraction sheet.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS:<\/jats:title>\n                  <jats:p>Nine high- or moderate-quality cohort studies were included in this study. VTI was administered in 38% to 53% of the OME cases, and more severe cases appeared more likely to undergo VTI. Compared with conservative forms of management (eg, watchful waiting), VTI has been shown to be beneficial to the recovery of hearing in children with cleft palate and OME. A growing body of evidence demonstrates the benefits of VTI in the development of speech and language in children with cleft palate and OME. These children face a higher risk of complications than those undergoing conservative treatments, the most common of which are eardrum retraction and tympanosclerosis, with an incidence of \u223c11% to 37%.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS:<\/jats:title>\n                  <jats:p>This review provides evidence-based information related to the selection of treatment for OME in children with cleft palate. Additional randomized controlled trials are required to obtain bias-resistant evidence capable of reliably guiding treatment decisions. The conclusions in this review are based on underpowered cohort studies and very-low-strength evidence.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1542\/peds.2014-0323","type":"journal-article","created":{"date-parts":[[2014,10,7]],"date-time":"2014-10-07T04:44:20Z","timestamp":1412657060000},"page":"983-994","source":"Crossref","is-referenced-by-count":81,"title":["Grommets for Otitis Media With Effusion in Children With Cleft Palate: A Systematic Review"],"prefix":"10.1542","volume":"134","author":[{"given":"Chin-Lung","family":"Kuo","sequence":"first","affiliation":[{"name":"Departments of Otolaryngology\u2013Head and Neck Surgery, and"},{"name":"Department of Otolaryngology,"},{"name":"Institute of Brain Science, and"},{"name":"Department of Otolaryngology, Taoyuan Armed Forces General Hospital, Taoyuan, Taiwan, Republic of China;"},{"name":"Department of Otolaryngology, National Defense Medical Center, Taipei, Taiwan, Republic of China; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan-Heng","family":"Tsao","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Taoyuan Armed Forces General Hospital, Taoyuan, Taiwan, Republic of China;"},{"name":"Department of Otolaryngology, National Defense Medical Center, Taipei, Taiwan, Republic of China; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao-Min","family":"Cheng","sequence":"additional","affiliation":[{"name":"Medical Research and Education, Taipei Veterans General Hospital, Taipei, Taiwan, Republic of China;"},{"name":"Cardiovascular Research Center, National Yang-Ming University School of Medicine, Taipei, Taiwan, Republic of China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiang-Feng","family":"Lien","sequence":"additional","affiliation":[{"name":"Departments of Otolaryngology\u2013Head and Neck Surgery, and"},{"name":"Department of Otolaryngology,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chyong-Hsin","family":"Hsu","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Mackay Memorial Hospital, Taipei, Taiwan, Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chii-Yuan","family":"Huang","sequence":"additional","affiliation":[{"name":"Departments of Otolaryngology\u2013Head and Neck Surgery, and"},{"name":"Department of Otolaryngology,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"An-Suey","family":"Shiao","sequence":"additional","affiliation":[{"name":"Departments of Otolaryngology\u2013Head and Neck Surgery, and"},{"name":"Department of Otolaryngology,"},{"name":"Department of Otolaryngology, National Defense Medical Center, Taipei, Taiwan, Republic of China; and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"417","published-online":{"date-parts":[[2014,11,1]]},"reference":[{"issue":"1","key":"2021121015575933900_B1","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1597\/07-219.1","article-title":"The management of otitis media with early routine insertion of grommets in children with cleft palate: a systematic review.","volume":"46","author":"Ponduri","year":"2009","journal-title":"Cleft Palate Craniofac J"},{"issue":"12","key":"2021121015575933900_B2","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1177\/014107688808101209","article-title":"The middle ear in cleft palate children pre and post palatal closure.","volume":"81","author":"Dhillon","year":"1988","journal-title":"J R Soc Med"},{"issue":"9","key":"2021121015575933900_B3","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1016\/j.ijporl.2013.07.015","article-title":"Otitis media with effusion in children with cleft lip and palate: a narrative review.","volume":"77","author":"Kuo","year":"2013","journal-title":"Int J Pediatr Otorhinolaryngol"},{"issue":"2","key":"2021121015575933900_B4","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.ijporl.2008.10.026","article-title":"Middle ear disease in children with cleft palate: protocols for management.","volume":"73","author":"Phua","year":"2009","journal-title":"Int J Pediatr Otorhinolaryngol"},{"issue":"1","key":"2021121015575933900_B5","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1002\/lary.22425","article-title":"Is otitis media with effusion almost always accompanying cleft palate in children? 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